<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tiblj</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и болезни легких</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and Lung Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-1230</issn><issn pub-type="epub">2542-1506</issn><publisher><publisher-name>Медицинские знания и технологии</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21292/2075-1230-2018-96-7-46-49</article-id><article-id custom-type="elpub" pub-id-type="custom">tiblj-1149</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ХАРАКТЕРИСТИКА БОЛЬНЫХ, ЗАБОЛЕВШИХ ТУБЕРКУЛЕЗОМ, В Г. КИШИНЭУ В 2015 Г.</article-title><trans-title-group xml:lang="en"><trans-title>CHARACTERISTICS OF THE PATIENTS WHO DEVELOPED TUBERCULOSIS IN CHISINAU IN 2015</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лесник</surname><given-names>Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Lesnik</surname><given-names>Evelina</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, ассистент кафедры.</p><p>г. Кишинев, бул. Штефан чел Маре, 165.</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Assistant of Department.</p><p>165, Stefan cel Mare si Sfant, Bd., Chisinau, Republic of Moldova</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нигуляну</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Nigulyanu</surname><given-names>Adriana</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, ассистент кафедры.</p><p>г. Кишинев, бул. Штефан чел Маре, 165.</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences, Assistant of Department.</p><p>165, Stefan cel Mare si Sfant, Bd., Chisinau, Republic of Moldova</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Малик</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Malik</surname><given-names>Alina</given-names></name></name-alternatives><bio xml:lang="ru"><p>ассистент кафедры.</p><p>г. Кишинев, бул. Штефан чел Маре, 165.</p></bio><bio xml:lang="en"><p>Assistant of Department.</p><p>165, Stefan cel Mare si Sfant, Bd., Chisinau, Republic of Moldova</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Яворский</surname><given-names>К.</given-names></name><name name-style="western" xml:lang="en"><surname>Yavosrkiy</surname><given-names>Konstantin</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, заведующий кафедрой пневмофтизиологии</p><p>г. Кишинев, бул. Штефан чел Маре, 165.</p></bio><bio xml:lang="en"><p>Doctor of Medical Sciences, Head of Phthisiology Department.</p><p>165, Stefan cel Mare si Sfant, Bd., Chisinau, Republic of Moldova</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный университет медицины и фармации Николая Тестемицану</institution><country>Молдова</country></aff><aff xml:lang="en"><institution>State University of Medicine and Pharmaceutics "Nicolae Testemitanu"</institution><country>Moldova, Republic of</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>16</day><month>08</month><year>2018</year></pub-date><volume>96</volume><issue>7</issue><fpage>46</fpage><lpage>49</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лесник Э., Нигуляну А., Малик А., Яворский К., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Лесник Э., Нигуляну А., Малик А., Яворский К.</copyright-holder><copyright-holder xml:lang="en">Lesnik E., Nigulyanu A., Malik A., Yavosrkiy K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tibl-journal.com/jour/article/view/1149">https://www.tibl-journal.com/jour/article/view/1149</self-uri><abstract><p>Цель исследования: характеристика больных, заболевших туберкулезом (ТБ), в г. Кишинэу в 2015 г.Материалы и методы. Проведено ретроспективное описательное исследование, в ходе которого проанализированы данные 668 пациентов с ТБ, диагностированных в г. Кишинэу в 2015 г.Результаты. Данные социальных характеристик показали, что в г. Кишинэу в 2015 г. чаще всего пациент с ТБ ‒ это мужчина молодого возраста, из социально уязвимых слоев населения, без медицинского страхования. Анализ методов выявления ТБ установил, что лишь 22,3% больных выявлены при периодическом обследовании групп высокого риска. Среди заболевших ТБ было впервые выявленных 60,3%, с рецидивом ‒ 21,7%, после перерыва в лечении –10,3%, после неудачи лечения ‒ 5,7 %. У 14 (2,0%) ‒ туберкулез выявлен посмертно.Среди 674 пациентов с прижизненной диагностикой туберкулеза преобладал ТБ легких ‒ 638 (94,7%), среди них у 193 (30,3%) больных микроскопия мокроты на кислотоустойчивые микобактерии была положительной, а 187 (29,3%) больных имели положительные результаты посева мокроты на среду Левенштейна ‒ Йенсена или в системе Bactec 960, результат Xpert MTB/Rif был положительным у 259 (40,6%). У 118/187 (63,1%) пациентов диагностирована множественная лекарственная устойчивость возбудителя.Через 12 мес. оценка лечения проведена у 647 пациентов: успешный курс лечения ‒ у 393 (60,7%) пациентов, 80 (12,4%) ‒ умерли, 174 (26,9%) ‒ продолжали лечение.</p></abstract><trans-abstract xml:lang="en"><p>The objective of the study: to characterize patients who developed tuberculosis in Chisinau in 2015.Subjects and methods. The retrospective descriptive study was conducted aimed to analyze data of 668 tuberculosis patients diagnosed in Chisinau in 2015.Results. The social characteristics demonstrated that in 2015 in Chisinau a tuberculosis patient was most often a young man belonging to socially marginalized population with no medical insurance. The analysis of tuberculosis detection methods showed that only 22.3% of patients were detected through regular screening in risk groups. Among tuberculosis patients, new cases made 60.3%, relapses – 21.7%, those after treatment interruption – 10.3%, and those after treatment failure – 5.7%. In 14 (2.0%) patients, tuberculosis was detected post-mortem.Out of 674 patients with life time diagnosed tuberculosis, pulmonary tuberculosis prevailed – 638 (94.7%), of them, 193 (30.3%) had a positive result of sputum microscopy for acid-fast bacilli, and 187 (29.3%) patients had a positive result of sputum culture by Lowenstein-Jensen or Bactec 960, and the result of Xpert MTB/Rif was positive in 259 (40.6%) patients. Multiple drug resistance was diagnosed in 118/187 (63.1%) patients.In 12 months, treatment outcomes were assessed in 647 patients: treatment was successful in 393 (60.7%) patients; 80 (12.4%) patients died, and 174 (26.9%) were still on treatment.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулез</kwd><kwd>методы выявления</kwd><kwd>социальные характеристики</kwd><kwd>микробиологические характеристики</kwd><kwd>исход лечения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tuberculosis</kwd><kwd>detection methods</kwd><kwd>social characteristics</kwd><kwd>microbiological parameters</kwd><kwd>treatment outcomes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Centre for Health Management. Statistical annuary of the health system from the Republic of Moldova. Chisinau. 2017.</mixed-citation><mixed-citation xml:lang="en">Centre for Health Management. Statistical annuary of the health system from the Republic of Moldova. Chisinau, 2017.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Cooker R., Mc Kee M., Atun R. Risk factors of pulmonary tuberculosis in Russia: case-control study // BMJ. ‒ 2006. ‒ Vol. 332. ‒ Р. 85.</mixed-citation><mixed-citation xml:lang="en">Cooker R., Mc Kee M., Atun R. Risk factors of pulmonary tuberculosis in Russia: case-control study. BMJ, 2006, vol. 332, pp. 85.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Dubos R. J., Dubos J. The white plague: tuberculosis. man and society. Rutgers University Press. 1952.</mixed-citation><mixed-citation xml:lang="en">Dubos R.J., Dubos J. The white plague: tuberculosis. man and society. Rutgers University Press. 1952.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Imtiaz S., Shield K. D., Roerecke M. Alcohol consumption as risk factor for tuberculosis: meta-amalyses and burden of disease // Eur. Respir. J. ‒ 2017. ‒ Vol. 13; 50 (1).</mixed-citation><mixed-citation xml:lang="en">Imtiaz S., Shield K.D., Roerecke M. Alcohol consumption as risk factor for tuberculosis: meta-amalyses and burden of disease. Eur. Respir. J., 2017, vol. 13, 50 (1).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Ministry of the Health of the R. of Moldova. National Protocol. Tuberculosis in adults. Chisinau, 2015.</mixed-citation><mixed-citation xml:lang="en">Ministry of the Health of the R. of Moldova. National Protocol. Tuberculosis in adults. Chisinau, 2015.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Murray C., Ortblad K., Guinovart C. et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 // Lancet. ‒ 2014. ‒ Vol. 384 (9947). ‒ Р. 1005-1070.</mixed-citation><mixed-citation xml:lang="en">Murray C., Ortblad K., Guinovart C. et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet, 2014, vol. 384 (9947), pp. 1005-1070.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. Global tuberculosis report. 2016.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. Global tuberculosis report. 2016.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. The global plan to stop TB 2011-2015: transforming the fight towards elimination of tuberculosis. Geneva. 2011.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. The global plan to stop TB 2011-2015: transforming the fight towards elimination of tuberculosis. Geneva, 2011.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
