tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2018-96-10-54-61tiblj-1187Research ArticleОБЗОРREVIEWЭозинофилы как неинвазивный маркер оценки воспалительной активности у пациентов с хронической обструктивной болезнью легкихEosinophils as a non-invasive marker to assess inflammatory activities in those suffering from chronic obstructive pulmonary diseaseКарнаушкинаМ. А.KаrnаushkinаM. A.

Карнаушкина Мария Александровна - доктор медицинских наук, доцент кафедры госпитальной терапии № 2.

119991, Москва, ул. Трубецкая, д. 8, стр. 2.

Maria A. Karnaushkina - Doctor of Medical Sciences, Professor of Hospital Therapy Department no. 2.

8, Bd. 2, Trubetskaya St., Moscow, 119991.

kar3745@yandex.ruДаниловР. С.DаnilovR. S.

Данилов Руслан Станиславович - врач-пульмонолог терапевтического отделения.

119192, Москва, Ломоносовский просп., д. 43.

Ruslan S. Danilov - Pulmonologist of Therapy Department.

43, Lomonosovsky Ave., Moscow, 119192.

danilovrus@yandex.ruФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» МЗ РФ (Сеченовский университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian FederationФБУЗ «Лечебно-реабилитационный центр Минэкономразвития России»РоссияMedical Rehabilitation Center of the Ministry of Economic Development of RussiaRussian Federation20180711201896105461Copyright © Карнаушкина М.А., Данилов Р.С., 20182018Карнаушкина М.А., Данилов Р.С.Kаrnаushkinа M.A., Dаnilov R.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1187

Представлен обзор последних исследований, посвященных оценке эозинофильного воспаления при хронической обструктивной болезни легких (ХОБЛ), а также возможности дифференцированной терапии как стабильной ХОБЛ, так и терапии ХОБЛ во время обострения. В настоящее время пороговый уровень эозинофилов крови, который может быть использован для принятия решений в клинической практике, окончательно не определен. Установлено лишь, что более высокий уровень эозинофилов крови может быть предиктором риска частых обострений и эффективности применения глюкокортикостероидов.

The article presents the review of latest studies devoted to assessment of the eosinophilic inflammation in chronic obstructive pulmonary disease (COPD) and opportunities for differential therapy of stable COPD and COPD therapy during exacerbation. Currently, there is no final definition what threshold blood level of eosinophils can be used for decision making in clinical practice. The only thing found out was that the high blood level of eosinophils could be a predictor of the risk of frequent exacerbations and the effectiveness of treatment with glucocorticosteroids.

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The authors declare that there are no conflicts of interest present.