tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2019-97-1-41-51tiblj-1219Research ArticleОБЗОРЫREVIEWSВНЕКЛЕТОЧНЫЕ МИКРОВЕЗИКУЛЯРНЫЕ ЧАСТИЦЫ В ПАТОГЕНЕЗЕ ТУБЕРКУЛЕЗАEXTRACELLULAR MICROVESICULAR PARTICLES IN THE PATHOGENESIS OF TUBERCULOSISПетренкоА. Е.PetrenkoA. E.

630040 г. Новосибирск, ул. Охотская, д. 81а

81a, Okhotskaya St., Novosibirsk, 630040

tonya.petrenko@gmail.comШварцЯ. Ш.ShvartzY. Sh.

630040 г. Новосибирск, ул. Охотская, д. 81а

81a, Okhotskaya St., Novosibirsk, 630040

yshschwartz@mail.ruБелогородцевС. Н.BelogorodtsevS. N.

630040 г. Новосибирск, ул. Охотская, д. 81а

81a, Okhotskaya St., Novosibirsk, 630040

s.belogorodtsev@mail.ruФГБУ «Новосибирский научно-исследовательский институт туберкулеза» МЗ РФ; ФГАОУ ВО «Новосибирский национальный исследовательский государственный университет (НГУ)»РоссияNovosibirsk Tuberculosis Research Institute; Novosibirsk State UniversityRussian FederationФГБУ «Новосибирский научно-исследовательский институт туберкулеза» МЗ РФРоссияNovosibirsk Tuberculosis Research InstituteRussian Federation2019060220199714151Copyright © Петренко А.Е., Шварц Я.Ш., Белогородцев С.Н., 20192019Петренко А.Е., Шварц Я.Ш., Белогородцев С.Н.Petrenko A.E., Shvartz Y.S., Belogorodtsev S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1219

В обзоре дается представление об основных классах внеклеточных микровезикулярных частиц, механизмах их биогенеза и возможной роли в развитии туберкулезной инфекции. Особое внимание уделено роли апоптоза инфицированных микобактериями туберкулеза макрофагов, генерации апоптотических эктосом и участию последних в формировании противотуберкулезного иммунного ответа.

Заключение: механизмы апоптотического блеббинга, собственно эктосомы и процессы клиринга этих частиц, возможно, могут стать в будущем новым инструментом патогенетической терапии туберкулеза.

The review describes main classes of extracellular microvesicular particles, mechanisms of their biogenesis and their potential role in the development of tuberculosis. Special attention is paid to apoptosis of macrophages infected with tuberculous mycobacteria, generation of apoptotic ectosome and involvement of the latter into the formation of anti-tuberculosis immune response. Conclusion: mechanisms of apoptotic blebbing, ectosomes and clearing of these particles possess the potential to become a new tool within pathogenetic therapy of tuberculosis.

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The authors declare that there are no conflicts of interest present.