tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2019-97-5-50-57tiblj-1270Research ArticleОБЗОРЫREVIEWSРезервуар ВИЧ у больных ВИЧ-инфекциейHIV reservoir in HIV patientsВеселоваЕ. И.VeselovaE. I.

младший научный сотрудник отдела инфекционной патологии

127473, Москва, ул. Достоевского, д. 4, корп. 2., Тел.: 8 (495) 622 98-28

Junior Researcher of Infectious Pathology Department

Build. 2, 4, Dostoevsky St., Moscow, Phone: +7 (495) 62298-28

КаминскийГ. Д.KaminskiyG. D.

доктор медицинских наук, руководитель отдела инфекционной патологии

127473, Москва, ул. Достоевского, д. 4, корп. 2., Тел.: 8 (495) 622 98-28

Doctor of Medical Sciences, Head of Infectious Pathology Department

Build. 2, 4, Dostoevsky St., Moscow, Phone: +7 (495) 62298-28

СамойловаА. Г.SamoylovaA. G.

доктор медицинских наук, заместитель директора по научной работе

127473, Москва, ул. Достоевского, д. 4, корп. 2., Тел.: 8 (495) 622 98-28

Doctor of Medical Sciences, Head of Infectious Pathology Department

Build. 2, 4, Dostoevsky St., Moscow, Phone: +7 (495) 62298-28

ВасильеваИ. А.VasilyevaI. A.

доктор медицинских наук, профессор, директор

127473, Москва, ул. Достоевского, д. 4, корп. 2., Тел.: 8 (495) 622 98-28

Doctor of Medical Sciences, Professor, Director

Build. 2, 4, Dostoevsky St., Moscow, Phone: +7 (495) 62298-28

ФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФРоссияNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesRussian Federation2019230520199755057Copyright © Веселова Е.И., Каминский Г.Д., Самойлова А.Г., Васильева И.А., 20192019Веселова Е.И., Каминский Г.Д., Самойлова А.Г., Васильева И.А.Veselova E.I., Kaminskiy G.D., Samoylova A.G., Vasilyeva I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1270

Резервуар ВИЧ представляет собой совокупность ДНК ВИЧ в клетках-мишенях в организме больного ВИЧ-инфекцией. Резервуар ВИЧ у больных ВИЧ-инфекцией препятствует эрадикации возбудителя и излечению от заболевания. В обзоре представлены данные литературы о структуре резервуара ВИЧ, его формировании и изменении размера резервуара на разных стадиях заболевания в зависимости от сроков начала лечения. Приведены результаты исследований, в которых изучалось влияние антиретровирусной терапии на размер резервуара и возможность использовать размер резервуара ВИЧ в качестве клинически значимого показателя течения заболевания. Рассмотрены современные стратегии воздействия на резервуар ВИЧ, конечной целью которых является выздоровление от ВИЧ-инфекции.

An HIV reservoir is a collection of HIV DNA in target cells in an HIV-infected person. HIV reservoir in patients with HIV infection prevents eradication of the pathogen and cure of the disease. The review presents published data on the structure of HIV reservoir, its formation and change of its size at different stages of the disease, depending on the time of treatment initiation. The article demonstrates the results of studies that investigated the effect of antiretroviral therapy on the size of the reservoir and the ability to use the size of HIV reservoir as a clinically significant indicator of the course of the disease. The current strategies for influencing on HIV reservoir are considered, the ultimate goal of which is recovery from HIV infection.

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The authors declare that there are no conflicts of interest present.