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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tiblj</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и болезни легких</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and Lung Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-1230</issn><issn pub-type="epub">2542-1506</issn><publisher><publisher-name>Медицинские знания и технологии</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21292/2075-1230-2019-97-10-31-36</article-id><article-id custom-type="elpub" pub-id-type="custom">tiblj-1343</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эпидемическая ситуация по туберкулезу у детей в Калужской области в 2014-2018 гг.</article-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis situation in children in Kaluga Region in 2014-2018</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лапшина</surname><given-names>И. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Lapshina</surname><given-names>I. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лапшина Ирина Сергеевна – кандидат медицинских наук, врач-фтизиатр.</p><p>248025, г. Калуга, ул. Луговая, д. 70.</p></bio><bio xml:lang="en"><p>Irina S. Lapshina – Candidate of Medical Sciences, Phthisiologist.</p><p>70, Lugovaya St., Kaluga, 248025</p></bio><email xlink:type="simple">geparin@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Замыслова</surname><given-names>Ю. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Zamyslova</surname><given-names>Yu. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Замыслова Юлия Николаевна – врач-фтизиатр.</p><p>248025, г. Калуга, ул. Луговая, д. 70.</p></bio><bio xml:lang="en"><p>Yulia N. Zamyslova – Phthisiologist.</p><p>70, Lugovaya St., Kaluga, 248025</p></bio><email xlink:type="simple">zamlavr@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мякишева</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Myakisheva</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мякишева Татьяна Владимировна –доктор медицинских наук, доцент, заведующая кафедрой фтизиопульмонологии.</p><p>214019, г. Смоленск ул. Крупской, д. 28.</p></bio><bio xml:lang="en"><p>Tatiana V. Myakisheva–Doctor of Medical Sciences, Associate Professor, Head of Phthisiopulmonology Department.</p><p>28, Krupskoy St., Smolensk, 214019</p></bio><email xlink:type="simple">tatya-myakisheva@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Парамонов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Paramonov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Парамонов Андрей Викторович – заместитель главного врача.</p><p>248025, г. Калуга, ул. Луговая, д. 70.</p></bio><bio xml:lang="en"><p>Andrey V. Paramonov – Deputy Head Physician.</p><p>70, Lugovaya St., Kaluga, 248025</p></bio><email xlink:type="simple">andrey_paramonov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреев</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Аndreev</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андреев Владимир Алексеевич – главный врач.</p><p>248025, г. Калуга, ул. Луговая, д. 70.</p></bio><bio xml:lang="en"><p>Vladimir A. Аndreev – Head Physician.</p><p>70, Lugovaya St., Kaluga, 248025</p></bio><email xlink:type="simple">andreev.vladimir@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ Калужской области «Областная клиническая туберкулезная больница» МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kaluga Regional Clinical TB Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ФГБОУ «Смоленский государственный медицинский университет» МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Smolensk State Medical University by Roszdrav</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>11</day><month>11</month><year>2019</year></pub-date><volume>97</volume><issue>10</issue><fpage>31</fpage><lpage>36</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Лапшина И.С., Замыслова Ю.Н., Мякишева Т.В., Парамонов А.В., Андреев В.А., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Лапшина И.С., Замыслова Ю.Н., Мякишева Т.В., Парамонов А.В., Андреев В.А.</copyright-holder><copyright-holder xml:lang="en">Lapshina I.S., Zamyslova Y.N., Myakisheva T.V., Paramonov A.V., Аndreev V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tibl-journal.com/jour/article/view/1343">https://www.tibl-journal.com/jour/article/view/1343</self-uri><abstract><sec><title>Цель</title><p>Цель: изучить эпидемическую ситуацию по туберкулезу среди детского населения в Калужской области в 2014-2018 гг.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Проведены анализ заболеваемости туберкулезом у детей и ее сравнение с эпидемиологическими показателями по туберкулезу у взрослых в 2014-2018 гг. Изучены первичная инфицированность детей микобактериями туберкулеза, структура III и IV ГДУ. Проанализированы все случаи впервые выявленного туберкулеза у детей в возрасте от 0 до 17 лет в 2014-2018 гг.</p></sec><sec><title>Результаты</title><p>Результаты. Показатели заболеваемости туберкулезом детей в Калужской области в 2014-2018 гг. имели разнонаправленные тенденции. Темп прироста показателя составил 0,9%, что выше прироста показателя общей заболеваемости и косвенно свидетельствует о наличии источников заражения среди взрослого населения. Не установлено статистически значимой корреляционной связи между показателями общей заболеваемости туберкулезом и заболеваемостью с бактериовыделением (r = 0,9; p &gt; 0,05), а также между заболеваемостью с бактериовыделением и заболеваемостью туберкулезом у детей (r = -0,48; p &gt; 0,05). Это указывает на дефекты в работе бактериологической службы, а также недовыявление детей из контактов с бактериовыделителями. Заболеваемость детей, состоящих на учете по контакту с больным туберкулезом, в Калужской области составила в среднем в 2014-2018 гг. 809,7 ± 306,1 на 100 тыс. детей из контактов.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Purpose</title><p>Purpose: to study tuberculosis situation in children in Kaluga Region in 2014-2018.</p></sec><sec><title>Subjects and methods</title><p>Subjects and methods. Tuberculosis incidence in children was analyzed and compared with tuberculosis rates in adults in 2014-2018. The primary infection of children with tuberculous mycobacteria, the structure of Dispensary Groups III and IV were studied. All new tuberculosis cases in children aged 0 to 17 years in 2014-2018 were analyzed.</p></sec><sec><title>Results</title><p>Results. In 2014-2018, there were mixed trends in tuberculosis incidence in children in Kaluga Region. The rate of tuberculosis incidence growth made 0.9%, which was higher than the growth in the overall incidence rate and indirectly indicated the presence of infection sources among adult population. No statistically significant correlation was found between the overall incidence of tuberculosis and the incidence of tuberculosis with a positive result of sputum test (r = 0.9; p &gt; 0.05), as well as between the incidence of tuberculosis with with a positive result of sputum test and tuberculosis incidence in children (r = -0.48; p &gt; 0.05). This points out at defects in the work of laboratory service as well as a poor detection of children exposed to infectious tuberculosis cases. In Kaluga Region, the average incidence in children registered as contacts of a tuberculosis case made 809.7 ± 306.1 per 100,000 children exposed to tuberculous infection in 2014-2018.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулез</kwd><kwd>дети</kwd><kwd>профилактика туберкулеза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tuberculosis</kwd><kwd>children</kwd><kwd>tuberculosis prevention</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аксенова В. А., Клевно Н. И., Севостьянова Т. А. Эпидемиологическая ситуация по туберкулезу у детей и подростков в России // Туб. и болезни легких. – 2011. – № 4. – С. 22.</mixed-citation><mixed-citation xml:lang="en">Аksenova V.А., Klevno N.I., Sevostyanova T.А. Tuberculosis epidemiological situation in children and adolescents in Russia. Tuberculosis and Lung Diseases, 2011, no. 4, pp. 22. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Филиппов А. В., Овсянкина Е. С. Изменение структуры показателя детской заболеваемости туберкулезом в условиях напряженной эпидемиологической ситуации // Туберкулез в России. Год 2007: Матер. VIII Рос. съезда фтизиатров. – М., – 2007. – С. 226.</mixed-citation><mixed-citation xml:lang="en">Filippov А.V., Ovsyankina E.S. Changes in tuberculosis incidence in children under the unfavorable epidemiological situation. Tuberculosis in Russia. Year of 2007: Materialy VIII Ros. syezda ftiziatrov. [Materials of VIIIth Conference of Russian TB Doctors]. Moscow, 2007, pp. 226. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Шовкун Л. А., Франчук И. М., Кампос Е. Д., Константинова А. В., Ильина О. В. Инновационные технологии в иммунологической диагностике туберкулеза у контактных лиц из очагов туберкулезной инфекции // Мед. вестник Юга России. – 2015. – № 3. – С. 116-119.</mixed-citation><mixed-citation xml:lang="en">Shovkun L.А., Franchuk I.M., Kampos E.D., Konstantinova А.V., Ilyina O.V. Innovative technologies in the immunological diagnostics of tuberculosis in those exposed to tuberculosis infection. Med. Vestnik Yuga Rossii, 2015, no. 3, pp. 116-119. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Shovkun L.A., Aksenova V.A., Kudlai D.A., Sarychev A.M. The role of immunological tests in the diagnosis of tuberculosis infection in children with juvenile idiopathic arthritis (JIA) // Eur. Resp. J. – 2018. – Vol. 52., № S62. – P. 2733.</mixed-citation><mixed-citation xml:lang="en">Shovkun L.A., Aksenova V.A., Kudlai D.A., Sarychev A.M. The role of immunological tests in the diagnosis of tuberculosis infection in children with juvenile idiopathic arthritis (JIA). Eur. Resp. J., 2018, vol. 52, no. S62. pp. 2733.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Slogotskaya L.V., Bogorodskaya E., Sentchichina O., Ivanova D., Nikitina G., Litvinov V., Seltsovsky, P., Kudlay D.A., Nikolenko N., Borisov S. Effectiveness of tuberculosis detection using a skin test with allergen recombinant (CFP-10-ESAT-6) in children // Eur. Respir. J. – 2015. – Vol. 46, № S59. – Р. 4524.</mixed-citation><mixed-citation xml:lang="en">Slogotskaya L.V., Bogorodskaya E., Sentchichina O., Ivanova D., Nikitina G., Litvinov V., Seltsovsky, P., Kudlay D.A., Nikolenko N., Borisov S. Effectiveness of tuberculosis detection using a skin test with allergen recombinant (CFP-10-ESAT-6) in children. Eur. Respir. J., 2015, vol. 46, no. S59, pp. 4524.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Slogotskaya L.V., Litvinov V., Ovsyankina E., Seltsovsky P., Kudlay D.A. Results of QuantiFERON-TB Gold in-tube and skin testing with recombinant proteins CFP-10-ESAT-6 in children and adolescents with TB or latent TB infection // Paediatr. Respir. Rev. – 2013. – Vol. 14, № 2. – P. 65.</mixed-citation><mixed-citation xml:lang="en">Slogotskaya L.V., Litvinov V., Ovsyankina E., Seltsovsky P., Kudlay D.A. Results of QuantiFERON-TB Gold in-tube and skin testing with recombinant proteins CFP-10-ESAT-6 in children and adolescents with TB or latent TB infection. Paediatr. Respir. Rev., 2013, vol. 14, no. 2, pp. 65.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
