tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2020-98-3-19-26tiblj-1404Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESНовая модель дормантности Mycobacterium tuberculosis in vitroA new in vitro dormancy model of Mycobacterium tuberculosisБатыршинаЯ. Р.BаtyrshinаYa. R.

Батыршина Яна Рэмовна - врач-бактериолог.

630040, Новосибирск, ул. Охотская, д. 81а, Тел./факс: + 7 (383)203-83-62, +7 (383)203-78-25

Yana R. Batyrshina - Bacteriologist.

81a, Okhotskaya St, Novosibirsk, 630040, Phone/Fax: +7 (383)203-83-62, +7 (383)203-78-25

batirshina@inbox.ruШварцЯ. Ш.ShvartsYa. Sh.

Шварц Яков Шмульевич - заместитель директора по науке.

630040, Новосибирск, ул. Охотская, д. 81а, Тел./факс: +7 (383) 203-83-58, +7 (383) 203-78-25

Yakov Sh. Shvarts - Deputy Director for Research.

yshschwartz@mail.ruФГБУ «Новосибирский НИИ туберкулеза» МЗ РФРоссияNovosibirsk Tuberculosis Research InstituteRussian Federation2020090420209831926Copyright © Батыршина Я.Р., Шварц Я.Ш., 20202020Батыршина Я.Р., Шварц Я.Ш.Bаtyrshinа Y.R., Shvarts Y.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1404

В статье представлена новая invitro модель дормантности M. tuberculosis, основанная на культивировании в условиях депривации четырех компонентов стандартной питательной среды Middlebrook 7H9. Детально описаны способ моделирования, характеристики полученного дормантного фенотипа M. tuberculosis, предложены области потенциального применения модели.

The article describes a new in vitro dormancy model of M. tuberculosis based on cultivation with deprivation of four components of the standard medium of Mediumbrook 7H9. The modeling method and characteristics of the obtained dormant phenotype of M. tuberculosis are described in detail, and fields for potential application of the model are proposed.

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The authors declare that there are no conflicts of interest present.