<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tiblj</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и болезни легких</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and Lung Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-1230</issn><issn pub-type="epub">2542-1506</issn><publisher><publisher-name>Медицинские знания и технологии</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21292/2075-1230-2020-98-7-37-43</article-id><article-id custom-type="elpub" pub-id-type="custom">tiblj-1442</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эпидемиология внелегочного туберкулеза в регионах с высокой заболеваемостью</article-title><trans-title-group xml:lang="en"><trans-title>Epidemiology of extrapulmonary tuberculosis in high-burden regions</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кульчавеня</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kulchavenya</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кульчавеня Екатерина Валерьевна, доктор медицинских наук, профессор,главный научный сотрудник</p><p>Тел./факс: 8 (383) 203-79-89, 8 (383) 203-86-75</p></bio><bio xml:lang="en"><p>Ekaterina V. Kulchavenya, Doctor of Medical Sciences, Professor, Head Researcher</p><p>Phone/Fax: +7 (383) 203-79-89; +7 (383) 203-86-75 </p></bio><email xlink:type="simple">urotub@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мерганов</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Merganov</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мерганов Махмадзариф Махмадшарифович, заведующий лимфоабдоминальным отделением</p><p>735400, Вахдатский район, г. Шифо</p></bio><bio xml:lang="en"><p>Makhmadzarif M. Merganov, Head of Lymphoabdominal Department</p><p>Shifo, Vakhdatsky District, 735400</p></bio><email xlink:type="simple">merganovz@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шарипов</surname><given-names>Ф. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Sharipov</surname><given-names>F. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шарипов Фируз Рустамович, директор</p><p>735400, Вахдатский район, г. Шифо </p><p>Тел.: +992919666685; +992907340909</p></bio><bio xml:lang="en"><p>Firuz R. Sharipov, Director</p><p>Shifo, Vakhdatsky District, 735400 </p><p>Phone: +992919666685; +992907340909 </p></bio><email xlink:type="simple">f85jon@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ «Новосибирский НИИ туберкулеза» МЗ РФ; ГБОУ ВПО «Новосибирский государственный медицинский университет» МЗ РФ</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Novosibirsk Tuberculosis Research Institute; Novosibirsk State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГУ «Национальный центр туберкулеза, заболеваний легких и торакальной хирургии»</institution><country>Таджикистан</country></aff><aff xml:lang="en"><institution>National Center of Tuberculosis, Lung Diseases and Thoracic Surgery</institution><country>Tajikistan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>15</day><month>08</month><year>2020</year></pub-date><volume>98</volume><issue>7</issue><fpage>37</fpage><lpage>43</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кульчавеня Е.В., Мерганов М.М., Шарипов Ф.Р., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Кульчавеня Е.В., Мерганов М.М., Шарипов Ф.Р.</copyright-holder><copyright-holder xml:lang="en">Kulchavenya E.V., Merganov M.M., Sharipov F.R.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tibl-journal.com/jour/article/view/1442">https://www.tibl-journal.com/jour/article/view/1442</self-uri><abstract><p>Цель исследования: оценить структуру внелегочного туберкулеза (ВТЛ) в двух эпидемически неблагополучных регионах (Сибирь, Дальний Восток РФ и Республика Таджикистан) с учетом ВИЧ-статуса, пола и возраста пациентов. Материал и методы. Простое когортное открытое ретроспективное исследование проведено на основе анализа статистических отчетов противотуберкулезных учреждений Республики Таджикистан, Сибирского (СФО) и Дальневосточного (ДФО) федерального округа РФ за 2018 г. Результаты. В СФО и ДФО РФ в структуре ВЛТ доля костно-суставного туберкулеза (КСТ) составила 43,6%, мочеполового – 21,3%, на третьем месте – туберкулез центральной нервной системы (ЦНС) – 17%. В Таджикистане ведущей локализацией также был КСТ ‒ 46,0%, на втором месте ‒ туберкулез периферических лимфатических узлов (ТПЛУ). В Таджикистане среди больных ВЛТ было всего 3,5% ВИЧ-позитивных, а в СФО и ДФО РФ ‒ 36,8%. При этом если в СФО и ДФО РФ среди больных с ВЛТ при ВИЧ-позитивном статусе преобладал туберкулез ЦНС (38,3%), то в Республике Таджикистан это был ТПЛУ (37,9%), затем КСТ (31,0%) и абдоминальный туберкулез (17,2%). Урогенитальный туберкулез был на последнем месте в структуре ВЛТ при ВИЧ-позитивном статусе.</p></abstract><trans-abstract xml:lang="en"><p>The objective of the study: to assess the structure of extrapulmonary tuberculosis in two high-burden regions (Siberia, the Far East of the Russian Federation, and the Republic of Tajikistan), with the consideration of HIV status, gender, and age of patients. Subjects and methods. A simple cohort open retrospective study was carried out based on the analysis of statistical reports from TB control institutions of the Republic of Tajikistan, Siberian and Far Eastern Federal Districts of the Russian Federation for 2018. Results. In the Siberian Federal District and Far Eastern Federal District, among extrapulmonary forms of tuberculosis, the proportion of bone and joint tuberculosis made 43.6%, urinary tuberculosis – 21.3%, and tuberculosis of central nervous system ranked third and made 17%. In Tajikistan, bone and joint tuberculosis also prevailed and made 46.0%, followed by tuberculosis of peripheral lymph nodes. In Tajikistan, among extrapulmonary tuberculosis patients, HIV positive patients made only 3.5%, while in the Siberian and Far Eastern Federal Districts, they made 36.8%. However, in the Siberian and Far Eastern Federal Districts of the Russian Federation, among HIV positive patients with extrapulmonary tuberculosis, tuberculosis of the central nervous system (38.3%) prevailed, in the Republic of Tajikistan it was tuberculosis of peripheral lymph nodes (37.9%), followed by bone and joint tuberculosis (31.0%) and abdominal tuberculosis (17.2%). Urogenital tuberculosis was in the last place in the structure of extrapulmonary tuberculosis in HIV-positive patients.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>внелегочный туберкулез</kwd><kwd>эпидемиология</kwd><kwd>заболеваемость</kwd><kwd>урогенитальный туберкулез</kwd><kwd>костно-суставной туберкулез</kwd><kwd>туберкулез периферических лимфоузлов</kwd></kwd-group><kwd-group xml:lang="en"><kwd>extrapulmonary tuberculosis</kwd><kwd>epidemiology</kwd><kwd>incidence</kwd><kwd>urogenital tuberculosis</kwd><kwd>bone and joint tuberculosis</kwd><kwd>tuberculosis of peripheral&#13;
lymph nodes</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кульчавеня Е. В., Брижатюк Е. В., Ковешникова Е. Новые тенденции в эпидемической ситуации по туберкулезу экстраторакальных локализаций в Сибири и на Дальнем Востоке // Туб. и болезни легких. ‒ 2009. ‒ Т. 86, № 10. ‒ С. 27-31.</mixed-citation><mixed-citation xml:lang="en">Kulchavenya E.V., Brizhatyuk E.V., Koveshnikova E. New tendencies in the epidemic situation of extrapulmonary tuberculosis in Siberia and the Far East. Tuberculosis and Lung Diseases, 2009, vol. 86, no. 10, pp. 27-31. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Солонко И. И., Гуревич Г. Л., Скрягина Е. М., Дюсьмикеева М. И. Внелегочный туберкулез: клинико-эпидемиологическая характеристика и диагностика // Туб. и болезни легких. ‒ 2018. ‒ Т. 96, № 9. ‒ С. 22-28. DOI:10.21292/2075-1230-2018-96-6-22-28.</mixed-citation><mixed-citation xml:lang="en">Solonko I.I., Gurevich G.L., Skryagina E.M., Dyusmikeeva M.I. Extrapulmonary tuberculosis: clinical and epidemiological characteristics and diagnostics. Tuberculosis and Lung Diseases, 2018, vol. 96, no. 9, pp. 22-28. (In Russ.) doi:10.21292/2075-1230-2018-96-6-22-28.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Туберкулез в Российской Федерации, 2012/2013/2014 гг. Аналитический обзор статистических показателей, используемых в Российской Федерации и в мире. ‒ М., 2015. ‒ 312 с.</mixed-citation><mixed-citation xml:lang="en">Tuberkulez v Rossiyskoy Federatsii 2012, 2013, 2014 g. Аnaliticheskiy obzor statisticheskikh pokazateley, ispolzuemykh v Rossiyskoy Federatsii i v mire. [Tuberculosis in the Russian Federation in 2012, 2013, 2014. Analytic review of statistic rates used in the Russian Federation and in the world]. Moscow, 2015, 312 p.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Ghafli H., Varghese B., Enani M., Alrajhi A., Al Johani S., Albarrak A., Althawadi S., Elkizzi N., Al Hajoj S. Demographic risk factors for extra-pulmonary tuberculosis among adolescents and adults in Saudi Arabia // PLoS One. ‒ 2019. ‒ Vol. 14, № 3. ‒ Р. e0213846. doi: 10.1371/journal.pone.0213846.eCollection 2019.</mixed-citation><mixed-citation xml:lang="en">Al-Ghafli H., Varghese B., Enani M., Alrajhi A., Al Johani S., Albarrak A., Althawadi S., Elkizzi N., Al Hajoj S. Demographic risk factors for extra-pulmonary tuberculosis among adolescents and adults in Saudi Arabia. PLoS One, 2019, vol. 14, no. 3, pp. e0213846. doi: 10.1371/journal.pone.0213846.eCollection 2019.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Al-Hajoj S., Shoukri M., Memish Z., AlHakeen R., AlRabaiah F., Vargne B. Exploring the sociodemographic and clinical features of extrapulmonary tuberculosis in Saudi Arabia // Plos One. ‒ 2015. ‒ Vol. 10, № 2. ‒ Р. e0101667. DOI: 10.1371/journal.pone.0101667.</mixed-citation><mixed-citation xml:lang="en">Al-Hajoj S., Shoukri M., Memish Z., AlHakeen R., AlRabaiah F., Vargne B. Exploring the sociodemographic and clinical features of extrapulmonary tuberculosis in Saudi Arabia. PLos One, 2015, vol. 10, no. 2, pp. e0101667. doi: 10.1371/journal.pone.0101667.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Arnedo-Pena A., Romeu-Garcia M. A., Meseguer-Ferrer N., Vivas-Fornas I., Vizcaino-Batllés A., Safont-Adsuara L., Bellido-Blasco J. B., Moreno-Muñoz R. Pulmonary versus extrapulmonary tuberculosis associated factors: a case-case study // Microbiol Insights. ‒ 2019. ‒ № 12:1178636119840362. doi: 10.1177/1178636119840362.eCollection 2019.</mixed-citation><mixed-citation xml:lang="en">Arnedo-Pena A., Romeu-Garcia M.A., Meseguer-Ferrer N., Vivas-Fornas I., Vizcaino-Batllés A., Safont-Adsuara L., Bellido-Blasco J.B., Moreno-Muñoz R. Pulmonary versus extrapulmonary tuberculosis associated factors: a case-case study. Microbiol Insights, 2019, no 12:1178636119840362. doi: 10.1177/1178636119840362.eCollection 2019.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gomes T., Reis-Santos B., Bertolde A., Johnson J. L., Riley L.W., Maciel E. L. Epidemiology of extrapulmonary tuberculosis in Brazil: a hierarchical model // BMC Infectious Diseases. ‒ 2014. ‒ № 14. ‒ Р. 9. http://www.biomedcentral.com/1471-2334/14/9.</mixed-citation><mixed-citation xml:lang="en">Gomes T., Reis-Santos B., Bertolde A., Johnson J.L., Riley L.W., Maciel E.L. Epidemiology of extrapulmonary tuberculosis in Brazil: a hierarchical model. BMC Infectious Diseases, 2014, no. 14, pp. 9. http://www.biomedcentral.com/1471-2334/14/9.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Gonzales O. Y., Adams G., Teeter L. D., Bui T. T., Musser S. M., Gravis E. A. Extra-pulmonary manifestations in a large metropolitan area with a low incidence of tuberculosis // Int. J. Tuberc. Lung Dis. ‒ 2003. ‒ Vol. 7, № 12. ‒ Р. 1178-1185.</mixed-citation><mixed-citation xml:lang="en">Gonzales O.Y., Adams G., Teeter L.D., Bui T.T., Musser S.M., Gravis E.A. Extra-pulmonary manifestations in a large metropolitan area with a low incidence of tuberculosis. Int. J. Tuberc. Lung Dis., 2003, vol. 7, no. 12, pp. 1178-1185.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kulchavenya E., Naber K., Johansen T. E. B. Influence of HIV infection on spectrum of extrapulmonary tuberculosis // J. Infect. Dis. Ther. ‒ 2018. ‒ № 6. ‒ Р. 377. doi:10.4172/2332-0877.1000377.</mixed-citation><mixed-citation xml:lang="en">Kulchavenya E., Naber K., Johansen T. E. B. Influence of HIV infection on spectrum of extrapulmonary tuberculosis. J. Infect. Dis. Ther., 2018, no. 6, pp. 377. doi:10.4172/2332-0877.1000377.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lee H. Y., Lee J., Lee Y. S., Kim M. Y., Lee H. K., Lee Y. M., Shin J. H., Ko Y. Drug-resistance pattern of Mycobacterium tuberculosis strains frompatients with pulmonary and extrapulmonary tuberculosis during 2006 to2013 in a Korean tertiary medical center // Korean J. Intern. Med. ‒ 2015. ‒ Vol. 30, № 3. ‒ Р. 325-334. doi: 10.3904/kjim.2015.30.3.325.</mixed-citation><mixed-citation xml:lang="en">Lee H.Y., Lee J., Lee Y.S., Kim M.Y., Lee H.K., Lee Y.M., Shin J.H., Ko Y. Drug-resistance pattern of Mycobacterium tuberculosis strains frompatients with pulmonary and extrapulmonary tuberculosis during 2006 to2013 in a Korean tertiary medical center. Korean J. Intern. Med., 2015, vol. 30, no. 3, pp. 325-334. doi: 10.3904/kjim.2015.30.3.325.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ohene S.-A., Bakker M. I., Ojo J., Toonstra A., Awudi D., Klatser P. Extra-pulmonary tuberculosis: a retrospective study of patients in Accra, Ghana // PLoS ONE. ‒ 2019. ‒ Vol. 14, № 1. ‒ Р. e0209650. https://doi.org/10.1371/journal.pone.0209650.</mixed-citation><mixed-citation xml:lang="en">Ohene S.A., Bakker M.I., Ojo J., Toonstra A., Awudi D., Klatser P. Extra-pulmonary tuberculosis: a retrospective study of patients in Accra, Ghana. PLoS ONE, 2019, vol. 14, no. 1, pp. e0209650. https://doi.org/10.1371/journal.pone.0209650.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Peto H. M., Pratt R. H., Harrington T. A., LoBue P. A., Armstrong L. R. Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006 // Clin. Infect. Dis. ‒2009. ‒ Vol. 49, № 9. ‒ Р. 1350-1357. doi: 10.1086/605559.</mixed-citation><mixed-citation xml:lang="en">Peto H.M., Pratt R.H., Harrington T.A., LoBue P.A., Armstrong L.R. Epidemiology of extrapulmonary tuberculosis in the United States, 1993-2006. Clin. Infect. Dis., 2009, vol. 49, no. 9, pp. 1350-1357. doi: 10.1086/605559.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Pollett S., Banner P., O’Sullivan M. V. N., Ralph A. P. Epidemiology, diagnosis and management of extra-pulmonary tuberculosis in a low-prevalence country: a four year retrospective study in an Australian tertiary infectious diseases unit // PLoS One. ‒ 2016. ‒ Vol. 11, № 3. ‒ Р. e0149372. doi: 10.1371/journal.pone.0149372</mixed-citation><mixed-citation xml:lang="en">Pollett S., Banner P., O’Sullivan M.V.N., Ralph A.P. Epidemiology, diagnosis and management of extra-pulmonary tuberculosis in a low-prevalence country: a four year retrospective study in an Australian tertiary infectious diseases unit. PLoS One, 2016, vol. 11, no. 3, pp. e0149372. doi: 10.1371/journal.pone.0149372</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Quddus M. A., Uddin M. J., Bhuiyan M. M. Evaluation of extra pulmonary tuberculosis in Bangladeshi patients // Mymensingh Med. J. ‒ 2014. ‒ Vol. 23, № 4. ‒ Р. 758-763.</mixed-citation><mixed-citation xml:lang="en">Quddus M.A., Uddin M.J., Bhuiyan M.M. Evaluation of extra pulmonary tuberculosis in Bangladeshi patients. Mymensingh Med. J., 2014, vol. 23, no. 4, pp. 758-763.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
