tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2020-98-8-63-74tiblj-1454Research ArticleОРИГИНАЛЬНЫЕ СТАТЬИORIGINAL ARTICLESБиомаркеры и иммунологические тесты. Экспериментально-клинические параллели латентной туберкулезной инфекцииBiomarkers and immunological tests. Experimental and clinical parallels of latent tuberculosis infectionhttps://orcid.org/0000-0003-1878-4467КудлайД. А.KudayD. A.

Кудлай Дмитрий Анатольевич, доктор медицинских наук, ведущий научный сотрудник лаборатории персонализированной медицины и молекулярной иммунологии; профессор кафедры фармакологии Института фармации

115478, Москва, Каширское шоссе, д. 24

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Tel.: +7 (499) 617-10-27

Dmitry A. Kudlay, Doctor of Medical Sciences, Leading Researcher of Personalized Medicine and Molecular Immunology Laboratory; Professor of Pharmacology Department of Pharmacy Institute

24, Kashirskoye Highway, Moscow, 115478

8, Bd. 2, Trubetskaya St., Moscow, 119991

Phone: +7 (499) 617-10-27

D624254@gmail.comФГБУ «Государственный научный центр «Институт иммунологии» Федерального медико-биологического агентства; ФГАОУ ВО Первый МГМУ им. И. М. Сеченова МЗ РФРоссияImmunology Research Institute by the Federal Medical Biological Agency; I. M. Sechenov First Moscow State Medical UniversityRussian Federation2020230920209886374Copyright © Кудлай Д.А., 20202020Кудлай Д.А.Kuday D.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1454

В обзоре использовано 94 источника литературы. Описаны эксперименты, проведенные на макаках Cynomolgus, по латентной туберкулезной инфекции. Отмечено, что в последние годы для идентификации грудных лимфатических узлов (ЛУ), инфицированных микобактериями туберкулеза (МБТ), стали применять ПЭТ-КТ. Показано, что с помощью ФДГ-ПЭТ-КТ можно судить о наличии жизнеспособных МБТ в торакальных ЛУ при латентной туберкулезной инфекции, что подтверждается культуральным определением живых МБТ в гранулемах этих ЛУ. Использование превентивной терапии способствует существенному сокращению видимой патологии при ПЭТ-КТ. В обзоре анализируются публикации, где в эксперименте показан спектр иммунного ответа на специфичные для МБТ белки ESAT-6 и CFP10 при туберкулезной инфекции, в частности связь между цитокиновым ответом и бактериальной нагрузкой.

The article presents the review of 94 publications. It describes experiments on latent tuberculosis infection on Cynomolgus macaques. It has been noted that in recent years, PET-CT has been used to identify thoracic lymph nodes (LN) infected with Mycobacterium tuberculosis (MTB). It has been demonstrated that FDG-PET-CT allows concluding about the presence of viable MTB in thoracic LNs in case of latent tuberculosis infection which is confirmed by detection of live MTB in granulomas of these LNs by culture. The preventive therapy contributes to a significant reduction of pathology visible on PET-CT. The review analyzes publications that experimentally show the spectrum of the immune response to MTB-specific proteins ESAT-6 and CFP10 in case of tuberculosis infection, in particular, the relationship between the cytokine response and bacterial load.

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The authors declare that there are no conflicts of interest present.