tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2021-99-2-6-15tiblj-1505Research ArticleОБЗОРREVIEWCOVID-19 и хроническая обструктивная болезнь легких: известное о неизвестномCOVID-19 and chronic obstructive pulmonary disease: what is known about the unknownОвсянниковЕ. С.OvsyannikovE. S.

Овсянников Евгений Сергеевич, кандидат медицинских наук, доцент кафедры факультетской терапии

394036, г. Воронеж, Студенческая ул., д. 10

Evgeny S. Ovsyannikov, Candidate of Medical Sciences, Associate Professor of Faculty Therapy Department

10, Studencheskaya St., Voronezh, 394036

ovses@yandex.ruАвдеевС. Н.AvdeevS. N.

Авдеев Сергей Николаевич, доктор медицинских наук, член-корреспондент РАН, заведующий кафедрой пульмонологии лечебного факультета

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Sergey N. Avdeev, Doctor of Medical Sciences, Correspondent Member of RAS, Head of Pulmonology Department of General Medicine Faculty

8, Bd. 2, Trubetskaya St., Moscow, 119991

serg_avdeev@list.ruБудневскийА. В.BudnevskiyA. V.

Будневский Андрей Валериевич, доктор медицинских наук, профессор, заведующий кафедрой факультетской терапии

394036, г. Воронеж, Студенческая ул., д. 10

 

Andrey V. Budnevskiy, Doctor of Medical Sciences, Professor, Head of Faculty Therapy Department

10, Studencheskaya St., Voronezh, 394036

budnev@list.ruДробышеваЕ. С.DrobyshevaE. S.

Дробышева Елена Сергеевна, кандидат медицинских наук, доцент кафедры факультетской терапии

394036, г. Воронеж, Студенческая ул., д. 10

Elena S. Drobysheva, Candidate of Medical Sciences, Associate Professor of Faculty Therapy Department

10, Studencheskaya St., Voronezh, 394036

e.drobysheva76@mail.ruКравченкоА. Я.KravchenkoA. Ya.

Кравченко Андрей Яковлевич, доктор медицинских наук, профессор кафедры факультетской терапии

394036, г. Воронеж, Студенческая ул., д. 10

Andrey Ya. Kravchenko, Doctor of Medical Sciences, Professor of Faculty Therapy Department

10, Studencheskaya St., Voronezh, 394036

drkay@yandex.ruФГБОУ ВО «Воронежский государственный медицинский университет им. Н. Н. Бурденко» МЗ РФРоссияVoronezh State Medical University Named After N. N. BurdenkoRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова МЗ РФ (Сеченовский университет)РоссияI. M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202110032021992615Copyright © Овсянников Е.С., Авдеев С.Н., Будневский А.В., Дробышева Е.С., Кравченко А.Я., 20212021Овсянников Е.С., Авдеев С.Н., Будневский А.В., Дробышева Е.С., Кравченко А.Я.Ovsyannikov E.S., Avdeev S.N., Budnevskiy A.V., Drobysheva E.S., Kravchenko A.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1505

Обзор 60 источников литературы посвящен ключевым аспектам, касающимся коморбидности COVID-19 и хронической обструктивной болезни легких (ХОБЛ). Содержит сведения, что у больных ХОБЛ повышена экспрессия рецептора ангиотензин-превращающего фермента 2 в легких, это может способствовать большей предрасположенности к COVID-19. При ХОБЛ выявлены признаки дисфункции эндотелиальных клеток и склонность к тромбообразованию, что может быть риском неблагоприятных исходов COVID-19. Данные когортных исследований не подтверждают, что пациенты с ХОБЛ в большей степени подвержены заражению SARS-CoV-2, но, по-видимому, клинические исходы COVID-19 у них хуже, включая потребность в искусственной вентиляции легких и летальность. Пока не получены клинические доказательства роли ингаляционных глюкокортикостероидов, используемых при ХОБЛ, в развитии и течении COVID-19.

The article reviews 60 publications and addresses key aspects of concurrent COVID-19 and chronic obstructive pulmonary disease (COPD). It presents data stating that COPD patients have higher expression of the receptor of angiotensin-converting enzyme 2 in the lungs and this may contribute to a greater susceptibility to COVID-19. In COPD, signs of endothelial cell dysfunction and tendency to thrombus formation have been identified which can present the risk of unfavorable outcomes of COVID-19. Cohort study data do not confirm that COPD patients are more susceptible to SARS-CoV-2 infection, but their clinical outcomes of COVID-19 appear to be worse including the need for mechanical ventilation and lethality. There is no clinical evidence about the role of inhaled glucocorticosteroids used to manage COPD in the development and course of COVID-19.

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The authors declare that there are no conflicts of interest present.