tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2021-99-3-58-66tiblj-1524Research ArticleОБЗОРREVIEWОсобенности обмена железа при туберкулезеSpecific parameters of iron metabolism in tuberculosishttps://orcid.org/0000-0002-9105-9264АбдуллаевР. Ю.АbdullаevR. Yu.

Абдуллаев Ризван Юсиф оглы – доктор медицинских наук, профессор, ведущий научный сотрудник отдела патанатомии, электронной микроскопии и биохимии, заведующий лабораторией биохимии. 

107564, Москва, Яузская аллея, д. 2.

Rizvan Yu. Аbdullaev – Doctor of Medical Sciences, Professor, Leading Researcher of Department for Pathological Anatomy, Electronic Microscopy and Biochemistry, Head of Biochemical Laboratory. 

2, Yauzskaya Alleya, Moscow, 107564.

rizvan0403@yandex.ruhttps://orcid.org/0000-0003-4427-3804КомиссароваО. Г.KomissаrovаO. G.

Комиссарова Оксана Геннадьевна – доктор медицинских наук, заместитель директора по научной и лечебной работе. 

107564, Москва, Яузская аллея, д. 2.

Oksana G. Komissarova – Doctor of Medical Sciences, Deputy Director for Research and Therapy. 

2, Yauzskaya Alleya, Moscow, 107564.

oksana.komissarova.72@mail.ruТерентьеваО. Р.TerentievаO. R.

Терентьева Ольга Романовна – заочный аспирант. 

107564, Москва, Яузская аллея, д. 2.

Oksana G. Komissarova – Doctor of Medical Sciences, Deputy Director for Research and Therapy. 

2, Yauzskaya Alleya, Moscow, 107564.

terentevaor@mail.ruФГБНУ «Центральный НИИ туберкулеза»РоссияCentral Tuberculosis Research InstituteRussian FederationФГБНУ «Центральный НИИ туберкулеза»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н. И. Пирогова»РоссияCentral Tuberculosis Research Institute; Pirogov Russian National Research Medical UniversityRussian Federation2021060420219935866Copyright © Абдуллаев Р.Ю., Комиссарова О.Г., Терентьева О.Р., 20212021Абдуллаев Р.Ю., Комиссарова О.Г., Терентьева О.Р.Аbdullаev R.Y., Komissаrovа O.G., Terentievа O.R.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1524

В обзоре представлены данные из 55 источников литературы об особенностях обмена железа в организме человека, в том числе при заболевании туберкулезом. Дано описание процессов, направленных на изолирование железа от патогенов и способствующих приобретению железа патогенами от макроорганизма. Снижение содержания циркулирующего в сыворотке крови железа при туберкулезе является прежде всего компонентом системного воспалительного ответа и относится к механизмам врожденного иммунитета, ограничивающим в организме человека размножение инфекционного возбудителя. При этом в падении уровня циркулирующего железа может участвовать его истинный дефицит.

The review presents data from 55 publications about specific parameters of iron metabolism in the human body including those ill with tuberculosis. It describes processes aimed at isolating iron from pathogens and promoting the acquisition of iron by pathogens from the host. A decrease in the level of iron circulating in the blood serum in the case of tuberculosis is primarily a component of the systemic inflammatory response and belongs to the mechanisms of innate immunity that limit the reproduction of an infectious agent in the human body. However, its true deficiency can be involved in the decrease in the level of circulating iron.

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The authors declare that there are no conflicts of interest present.