tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2021-99-5-64-70tiblj-1541Research ArticleОБЗОРREVIEWКлофазимин: история и перспективыClofazimine: History and PerspectivesМожокинаГ. Н.,MozhokinaG. N.

Можокина Галина Николаевна, доктор медицинских наук, ведущий научный сотрудник лаборатории иммунопатологии и иммунодиагностики туберкулезной инфекции

127473, Москва, ул. Достоевского, д. 4, к. 2

Galina N. Mozhokina, Doctor of Medical Sciences, Leading Researcher of Laboratory of Immunopathology and Immunodiagnostics of Tuberculosis Infection

Build. 2, 4, Dostoevskiy St., Moscow, 127473

mojokina@mail.ruСамойловаА. Г.SamoylovaA. G.

Самойлова Анастасия Геннадьевна, доктор медицинских наук, заместитель директора по научной работе

127473, Москва, ул. Достоевского, д. 4, к. 2

Anastasiya G. Samoylova, Doctor of Medical Sciences, Deputy Director for Research

Build. 2, 4, Dostoevskiy St., Moscow, 127473

a.samoilova.nmrc@mail.ruФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФРоссияNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesRussian Federation2021110620219956470Copyright © Можокина Г.Н., Самойлова А.Г., 20212021Можокина Г.Н., Самойлова А.Г.Mozhokina G.N., Samoylova A.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1541

В обзоре представлен анализ 47 публикаций, прослеживающих путь клофазимина от открытия до признания препаратом группы В для лечения туберкулеза с множественной лекарственной устойчивостью. Приведены сведения о механизмах действия на микобактерии туберкулеза, особенностях фармакокинетики и профиле безопасности.

The review analyses 47 publications that follow the pathway of clofazimine from its discovery to recognition as a Group B drug for treatment of multiple drug resistant tuberculosis. It describes its mechanism of action and effects on Mycobacterium tuberculosis, pharmacokinetics, and safety parameters.

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The authors declare that there are no conflicts of interest present.