tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.21292/2075-1230-2022-100-4-6-13tiblj-1627Research ArticleCOVID-19COVID-19TREC и KREC как маркеры прогноза ВИЧ-инфекции и COVID-19TREC and KREC as prognostic markers of HIV infection and COVID-19https://orcid.org/0000-0003-4339-126XВеселоваЕ. И.VeselovaE. I.

Веселова Елена Игоревна, научный сотрудник научного отдела инфекционной патологии

127473, Москва, ул. Достоевского, д. 4 к. 2

Elena I. Veselova, Researcher of Infectious Pathology Research Department

Build. 2, 4, Dostoevskiy St., Moscow, 127473

drveselovae@mail.ruhttps://orcid.org/0000-0002-3091-4677ЛовачеваО. В.LovachevaO. V.

Ловачева Ольга Викторовна, доктор медицинских наук, профессор, главный научный сотрудник

127473, Москва, ул. Достоевского, д. 4 к. 2

Olga V. Lovacheva, Doctor of Medical Sciences, Professor, Senior Researcher

Build. 2, 4, Dostoevskiy St., Moscow, 127473

olga.lovacheva@yandex.ruhttps://orcid.org/0000-0001-6596-9777СамойловаА. Г.SamoylovaА. G.

Самойлова Анастасия Геннадьевна, доктор медицинских наук, первый заместитель директора

127473, Москва, ул. Достоевского, д. 4 к. 2

Anastasiya G. Samoylova, Doctor of Medical Sciences, First Deputy Director

Build. 2, 4, Dostoevskiy St., Moscow, 127473

a.samoilova.nmrc@mail.ruhttps://orcid.org/0000-0003-1878-4467КудлайД. А.KudlayD. А.

Кудлай Дмитрий Анатольевич, доктор медицинских наук, профессор, ведущий научный сотрудник лаборатории персонализированной медицины и молекулярной иммунологии № 71

119991, Москва, ул. Трубецкая, д. 8, стр. 2

Dmitry A. Kudlay, Doctor of Medical Sciences, Leading Researcher of Personalized Medicine and Molecular Immunology Laboratory no.71

8, Bd. 2, Trubetskaya St., Moscow, 119991

D624254@gmail.comhttps://orcid.org/0000-0002-3016-6920КаминскийГ. Д.KaminskiyG. D.

Каминский Григорий Дмитриевич, доктор медицинских наук, руководитель научного отдела инфекционной патологии

127473, Москва, ул. Достоевского, д. 4 к. 2

Grigoriy D. Kaminskiy, Doctor of Medical Sciences, Head of Infectious Pathology Research Department

Build. 2, 4, Dostoevskiy St., Moscow, 127473

gregkaminski.gk@gmail.comФГБУ «Научный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФРоссияNational Medical Research Center of Phthisiopulmonology and Infectious DiseasesRussian FederationФГБУ «Государственный научный центр “Институт иммунологии”» Федерального медико-биологического агентства России; ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова (Сеченовский университет) МЗ РФРоссияImmunology Research Institute by the Federal Medical Biological Agency; I. M. Sechenov First Moscow State Medical University (Sechenov University),Russian Federation2022140520221004613Copyright © Веселова Е.И., Ловачева О.В., Самойлова А.Г., Кудлай Д.А., Каминский Г.Д., 20222022Веселова Е.И., Ловачева О.В., Самойлова А.Г., Кудлай Д.А., Каминский Г.Д.Veselova E.I., Lovacheva O.V., Samoylova А.G., Kudlay D.А., Kaminskiy G.D.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1627

При некоторых инфекционных заболеваниях значительно снижается количество Т- и В-лимфоцитов, что сопряжено с высоким риском прогрессирования заболевания. В обзоре рассмотрено влияние на специфическое звено иммунитета двух РНК-содержащих вирусов: SARS-CoV-2 и ВИЧ, а также показатели Т- и В- клеточного неогенеза TREC и KREC, которые являются маркерами иммунологических нарушений и могут быть использованы для их прогноза.

In some infectious diseases, the number of T- and B-lymphocytes is significantly reduced which is associated with a high risk of the disease progression. The article reviews the effect of two RNA-containing viruses on the specific immune system: SARS-CoV-2 and HIV, as well as parameters of T- and B-cell neogenesis of TREC and KREC, which are markers of immunological disorders and can be used for prognosis for these infections.

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The authors declare that there are no conflicts of interest present.