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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tiblj</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и болезни легких</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and Lung Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-1230</issn><issn pub-type="epub">2542-1506</issn><publisher><publisher-name>Медицинские знания и технологии</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21292/2075-1230-2022-100-4-62-66</article-id><article-id custom-type="elpub" pub-id-type="custom">tiblj-1635</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEWS</subject></subj-group></article-categories><title-group><article-title>Использование мезенхимных стволовых клеток в терапии туберкулеза</article-title><trans-title-group xml:lang="en"><trans-title>Use of mesenchymal stem cells in therapy of tuberculosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8145-4159</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ремезова</surname><given-names>А. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Remezova</surname><given-names>А. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ремезова Анна Николаевна, ординатор кафедры госпитальной хирургии</p><p>199034, Санкт-Петербург, Университетская наб., д. 7-9</p></bio><bio xml:lang="en"><p>Anna N. Remezova, Resident Physician of Hospital Surgery Department</p><p>7-9, Universitetskaya Nab., St. Petersburg, 199034</p></bio><email xlink:type="simple">urolog-remezovaanna@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7010-7562</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горелова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorelova</surname><given-names>А. А.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горелова Анна Андреевна, ассистент</p><p>191036, Санкт-Петербург, Лиговский пр., д. 2-4</p><p>199034, Санкт-Петербург, Университетская наб., д. 7-9</p></bio><bio xml:lang="en"><p>Anna A. Gorelova, Assistant</p><p>2-4, Ligovsky Ave., St. Petersburg, 191036</p><p>7-9, Universitetskaya Nab., St. Petersburg, 199034</p></bio><email xlink:type="simple">gorelova_a@yahoo.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5234-349X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Виноградова</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Vinogradova</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Виноградова Татьяна Ивановна, доктор медицинских наук, профессор, главный научный сотрудник</p><p>191036, Санкт-Петербург, Лиговский пр., д. 2-4</p><p> </p></bio><bio xml:lang="en"><p>Tatyana I. Vinogradova, Doctor of Medical Sciences, Professor, Senior Researcher</p><p>2-4, Ligovsky Ave., St. Petersburg, 191036</p></bio><email xlink:type="simple">vinogradova@spbniif.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2858-5317</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горелов</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorelov</surname><given-names>А. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горелов Андрей Игоревич, доктор медицинских наук, профессор, профессор кафедры урологии медицинского факультета</p><p>199034, Санкт-Петербург, Университетская наб., д. 7-9</p></bio><bio xml:lang="en"><p>Andrey I. Gorelov, Doctor of Medical Sciences, Professor, Professor of Urology Department, Medicine Faculty</p><p>7-9, Universitetskaya Nab., St. Petersburg, 199034</p></bio><email xlink:type="simple">gorelov_a_i@mail.ru</email><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0656-4187</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунов</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunov</surname><given-names>А. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горбунов Александр Игоревич, младший научный сотрудник направления «Урология, гинекология и абдоминальная хирургия»</p><p>191036, Санкт-Петербург, Лиговский пр., д. 2-4</p></bio><bio xml:lang="en"><p>Aleksandr I. Gorbunov, Researcher in Urology, Gynecology and Abdominal Surgery</p><p>2-4, Ligovsky Ave., St. Petersburg, 191036</p></bio><email xlink:type="simple">alx.urolog@gmail.com</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7357-1571</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юдинцева</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Yudintseva</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юдинцева Наталия Михайловна, кандидат биологических наук, старший научный сотрудник</p><p>194064, Санкт-Петербург, Тихорецкий просп., д. 4</p></bio><bio xml:lang="en"><p>Natalia M. Yudintseva, Candidate of Biological Sciences, Senior Researcher</p><p>4, Tikhoretskiy Ave., St. Petersburg 194064</p></bio><email xlink:type="simple">yudintceva@mail.ru</email><xref ref-type="aff" rid="aff-5"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ФГБОУ ВО «Санкт-Петербургский государственный университет»<country>Россия</country></aff><aff xml:lang="en">St. Petersburg University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ; ФГБОУ ВО «Санкт-Петербургский государственный университет»<country>Россия</country></aff><aff xml:lang="en">St. Petersburg Research Institute of Phthisiopulmonology; St. Petersburg University<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">ФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ<country>Россия</country></aff><aff xml:lang="en">St. Petersburg Research Institute of Phthisiopulmonology<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">ФГБОУ ВО «Санкт-Петербургский государственный университет»;СПБ ГБУЗ «Городская Покровская больница»<country>Россия</country></aff><aff xml:lang="en">St. Petersburg University; Pokrovskaya City Hospital<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">ФГБУН «Институт цитологии Российской академии наук (ИНЦ РАН)»<country>Россия</country></aff><aff xml:lang="en">Institute of Cytology, the Russian Academy of Sciences<country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>14</day><month>05</month><year>2022</year></pub-date><volume>100</volume><issue>4</issue><fpage>62</fpage><lpage>66</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ремезова А.Н., Горелова А.А., Виноградова Т.И., Горелов А.И., Горбунов А.И., Юдинцева Н.М., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Ремезова А.Н., Горелова А.А., Виноградова Т.И., Горелов А.И., Горбунов А.И., Юдинцева Н.М.</copyright-holder><copyright-holder xml:lang="en">Remezova А.N., Gorelova А.А., Vinogradova T.I., Gorelov А.I., Gorbunov А.I., Yudintseva N.M.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tibl-journal.com/jour/article/view/1635">https://www.tibl-journal.com/jour/article/view/1635</self-uri><abstract><p>В обзоре представлены данные из 29 источников литературы, посвященных использованию мезенхимных стволовых клеток в терапии туберкулеза различной локализации. Также описаны некоторые механизмы взаимодействия мезенхимных стволовых клеток с M. tuberculosis.</p></abstract><trans-abstract xml:lang="en"><p>This review presents data from 29 publications on the use of mesenchymal stem cells in the therapy of tuberculosis of various localizations. It also describes some mechanisms of interaction between mesenchymal stem cells and M. tuberculosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мезенхимные стволовые клетки</kwd><kwd>туберкулез</kwd><kwd>множественная лекарственная устойчивость</kwd></kwd-group><kwd-group xml:lang="en"><kwd>mesenchymal stem cells</kwd><kwd>tuberculosis</kwd><kwd>multiple drug resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ариэль Б. М., Гусейнова Ф. М., Виноградова Т. И. и др. Мезенхимные клетки стромы костного мозга при туберкулезе гениталий у кроликов (экспериментальное исследование с морфологическим контролем) // Обзоры по клинической фармакологии и лекарственной терапии. ‒ 2017. ‒ Т. 15, № 2. ‒ С. 47-55.</mixed-citation><mixed-citation xml:lang="en">Аriel B.M., Guseynova F.M., Vinogradova T.I. et al. Mesenchymal stem cells of the bone marrow in treatment of genital tuberculosis in rabbits (experimental research with morphological control). Obzory Po Klinicheskoy Farmakologii I Lekarstvennoy Terapii, 2017, vol. 15, no. 2, pp. 47-55. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гусейнова Ф. М., Виноградова Т. И., Заболотных Н. В. и др. Влияние клеточной терапии мезенхимными клетками стромы костного мозга на процессы репарации при экспериментальном туберкулезном сальпингите // Медицинский альянс. – 2017. – № 3. – С. 35-43.</mixed-citation><mixed-citation xml:lang="en">Guseynova F.M., Vinogradova T.I., Zabolotnykh N.V. at al. The impact of cellular therapy with mesenchymal stem cells of bone marrow on reparation at experimental tuberculous salpingitis. Meditsinsky Alyans, 2017, no. 3, pp. 35-43. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Ерохин В. В., Васильева И. А., Коноплянников А. Г. и др. Системная трансплантация аутологичных мезенхимальных стволовых клеток костного мозга в лечении больных множественным лекарственно-устойчивым туберкулезом легких // Туб. и болезни легких. – 2008. – Т. 85, № 10. – С. 3-6.</mixed-citation><mixed-citation xml:lang="en">Erokhin V.V., Vasilyeva I.А., Konoplyannikov А.G. et al. System transplantation of self-specific mesenchymal bone marrow stem cells for treatment of multiple drug resistant pulmonary tuberculosis patients. Tuberculosis and Lung Diseases, 2008, vol. 85, no. 10, pp. 3-6. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Орлова Н. В., Муравьев А. Н., Блюм Н. М. и др. Экспериментальная реконструкция мочевого пузыря кролика с использованием аллогенных клеток различного тканевого происхождения // Медицинский альянс. – 2016. – № 1. – С. 50-52.</mixed-citation><mixed-citation xml:lang="en">Orlova N.V., Muraviev А.N., Blyum N.M. at al. Experimental urinary bladder reconstruction in the rabbit using self-specific cells of various tissue origin. Meditsinsky Alyans, 2016, no. 1, pp. 50-52. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Cohen K. A., Abeel T., McGuire A. M. et al. Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa // Intern. J. Mycobacter. – 2015. – Vol. 4. – P. 24-25. doi:10.1016/j.ijmyco.2014.11.028.</mixed-citation><mixed-citation xml:lang="en">Cohen K.A., Abeel T., McGuire A.M. et al. Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa. Intern. J. Mycobacter., 2015, vol. 4, pp. 24-25. doi:10.1016/j.ijmyco.2014.11.028.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Danjuma L., Mok P. L., Higuchi A. et al. Modulatory and regenerative potential of transplanted bone marrow-derived mesenchymal stem cells on rifampicin-induced kidney toxicity // Regenera. Ther. – 2018. – Vol. 9. – P. 100-110. doi:10.1016/j.reth.2018.09.001.</mixed-citation><mixed-citation xml:lang="en">Danjuma L., Mok P.L., Higuchi A. et al. Modulatory and regenerative potential of transplanted bone marrow-derived mesenchymal stem cells on rifampicin-induced kidney toxicity. Regenera. Ther., 2018, vol. 9, pp. 100-110. doi:10.1016/j.reth.2018.09.001.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Das B., Kashino S. S., Pulu I. et al. CD271+ bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis // Sci. Translat. Med.. – 2013. – Vol. 5, Iss. 170. – P. 170. doi: 10.1126/scitranslmed.3004912.</mixed-citation><mixed-citation xml:lang="en">Das B., Kashino S.S., Pulu I. et al. CD271+ bone marrow mesenchymal stem cells may provide a niche for dormant Mycobacterium tuberculosis. Sci. Translat. Med., 2013, vol. 5, iss. 170, pp. 170. doi: 10.1126/scitranslmed.3004912.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Espinal M. A., Laszlo A., Simonsen L. et al. Global trends in resistance to antituberculosis drugs // New Engl. J. Med. – 2001. – Vol. 344, Iss. 17. – P. 1294-1303. doi: 10.1056/NEJM200104263441706.</mixed-citation><mixed-citation xml:lang="en">Espinal M.A., Laszlo A., Simonsen L. et al. Global trends in resistance to antituberculosis drugs. New Engl. J. Med., 2001, vol. 344, iss. 17, pp. 1294-1303. doi: 10.1056/NEJM200104263441706.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Fatima S., Kamble,S. S., Dwivedi V. P. et al. Mycobacterium tuberculosis programs mesenchymal stem cells to establish dormancy and persistence // J. Clin. Invest. – 2020. – Vol. 130, Iss. 2. – P. 655-661. doi: 10.1172/JCI128043.</mixed-citation><mixed-citation xml:lang="en">Fatima S., Kamble,S.S., Dwivedi V.P. et al. Mycobacterium tuberculosis programs mesenchymal stem cells to establish dormancy and persistence. J. Clin. Invest., 2020, vol. 130, iss. 2, pp. 655-661. doi: 10.1172/JCI128043.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Gomez J. E., McKinney J. D. M. tuberculosis persistence, latency, and drug tolerance // Tuberculosis. – 2004. – Vol. 84, Iss. 1-2. – P. 29-44. doi:10.1016/j.tube.2003.08.003.</mixed-citation><mixed-citation xml:lang="en">Gomez J.E., McKinney J.D. M. tuberculosis persistence, latency, and drug tolerance. Tuberculosis, 2004, vol. 84, iss. 1-2. pp. 29-44. doi:10.1016/j.tube.2003.08.003.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gutierrez M. G., Master S. S., Singh S. B. et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages // Cell. – 2004. – Vol. 119, Iss. 6. – P. 753-766. doi:10.1016/j.cell.2004.11.038.</mixed-citation><mixed-citation xml:lang="en">Gutierrez M.G., Master S.S., Singh S.B. et al. Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell, 2004, vol. 119, iss. 6, pp. 753-766. doi:10.1016/j.cell.2004.11.038.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Islam M. N., Das S. R., Emin M. T. et al. Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury // Nature Med. – 2012. – Vol. 18, Iss. 5. – P. 759-765. doi:10.1038/nm.2736.</mixed-citation><mixed-citation xml:lang="en">Islam M.N., Das S.R., Emin M.T. et al. Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury. Nature Med., 2012, vol. 18, iss. 5, pp. 759-765. doi:10.1038/nm.2736.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Khan A., Mann L., Papanna R. et al. Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy // Sci. Reports. – 2017. – Vol. 7, Iss. 1. – P. 1-15. doi:10.1038/s41598-017-15290-z.</mixed-citation><mixed-citation xml:lang="en">Khan A., Mann L., Papanna R. et al. Mesenchymal stem cells internalize Mycobacterium tuberculosis through scavenger receptors and restrict bacterial growth through autophagy. Sci. Reports, 2017, vol. 7, iss. 1, pp. 1-15. doi:10.1038/s41598-017-15290-z.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Levitte S., Adams K. N., Berg R. D. et al. Mycobacterial acid tolerance enables phagolysosomal survival and establishment of tuberculous infection in vivo // Cell Host &amp; Microbe. – 2016. – Vol. 20, Iss. 2. – P. 250-258. doi:10.1016/j.chom.2016.07.007.</mixed-citation><mixed-citation xml:lang="en">Levitte S., Adams K.N., Berg R.D. et al. Mycobacterial acid tolerance enables phagolysosomal survival and establishment of tuberculous infection in vivo. Cell Host &amp; Microbe, 2016, vol. 20, iss. 2, pp. 250-258. doi:10.1016/j.chom.2016.07.007.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Matthay M. A., Goolaerts A., Howard J. P. et al. Mesenchymal Stem Cells for Acute Lung Injury: Preclinical Evidence // Crit. Care Med. – 2010. – Vol. 38, Iss. 10. – P. 569-573. doi: 10.1097/CCM.0b013e3181f1ff1d.</mixed-citation><mixed-citation xml:lang="en">Matthay M.A., Goolaerts A., Howard J.P. et al. Mesenchymal Stem Cells for Acute Lung Injury: Preclinical Evidence. Crit. Care Med., 2010, vol. 38, iss. 10, pp. 569-573. doi: 10.1097/CCM.0b013e3181f1ff1d.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Mei S. H., McCarter S. D., Deng Y. et al. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1 // PLoS Med. – 2007. – Vol. 4, Iss. 9. – P. e269. doi:10.1371/journal.pmed.0040269.</mixed-citation><mixed-citation xml:lang="en">Mei S.H., McCarter S.D., Deng Y. et al. Prevention of LPS-induced acute lung injury in mice by mesenchymal stem cells overexpressing angiopoietin 1. PLoS Med., 2007, vol. 4, iss. 9, pp. e269. doi:10.1371/journal.pmed.0040269.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Parida S. K. Madansein R., Singh N. et al. Cellular therapy in tuberculosis // Intern. J. Infect. Dis. – 2015. – Vol. 32. – P. 32-38. doi:10.1016/j.ijid.2015.01.016.</mixed-citation><mixed-citation xml:lang="en">Parida S.K. Madansein R., Singh N. et al. Cellular therapy in tuberculosis. Intern. J. Infect. Dis., 2015, vol. 32, pp. 32-38. doi:10.1016/j.ijid.2015.01.016.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Raghuvanshi S., Sharma P., Singh S. et al. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells // Proceedings of the National Academy of Sciences. – 2010. – Vol. 107, Iss. 50. – P. 21653-21658. doi:10.1073/pnas.1007967107.</mixed-citation><mixed-citation xml:lang="en">Raghuvanshi S., Sharma P., Singh S. et al. Mycobacterium tuberculosis evades host immunity by recruiting mesenchymal stem cells. Proceedings of the National Academy of Sciences, 2010, vol. 107, iss. 50, pp. 21653-21658. doi:10.1073/pnas.1007967107.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Shah N. S., Wright A., Bai G. H. et al. Worldwide emergence of extensively drug-resistant tuberculosis // Emerg. Infect. Dis. – 2007. – Vol. 13, Iss. 3. – P. 380. doi:10.3201/eid1303.061400.</mixed-citation><mixed-citation xml:lang="en">Shah N.S., Wright A., Bai G.H. et al. Worldwide emergence of extensively drug-resistant tuberculosis. Emerg. Infect. Dis., 2007, vol. 13, iss. 3, pp. 380. doi:10.3201/eid1303.061400.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Sinclair K., Yerkovich S. T., Chambers D. C. Mesenchymal stem cells and the lung // Respirology. – 2013. – Vol. 18, Iss. 3. – P. 397-411. doi:10.1111/resp.12050.</mixed-citation><mixed-citation xml:lang="en">Sinclair K., Yerkovich S.T., Chambers D.C. Mesenchymal stem cells and the lung. Respirology, 2013, vol. 18, iss. 3, pp. 397-411. doi:10.1111/resp.12050.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Skrahin A., Ahmed R. K., Ferrara G. et al. Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial // Lancet Respir. Med. – 2014. – Vol. 2, Iss. 2. – P. 108-122. doi:10.1016/S2213-2600(13)70234-0.</mixed-citation><mixed-citation xml:lang="en">Skrahin A., Ahmed R.K., Ferrara G. et al. Autologous mesenchymal stromal cell infusion as adjunct treatment in patients with multidrug and extensively drug-resistant tuberculosis: an open-label phase 1 safety trial. Lancet Respir. Med., 2014, vol. 2, iss. 2, pp. 108-122. doi:10.1016/S2213-2600(13)70234-0.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Spees J. L., Olson S. D., Whitney M. J. et al. Mitochondrial transfer between cells can rescue aerobic respiration // Proceedings of the National Academy of Sciences. – 2006. – Vol. 103, Iss. 5. – P. 1283-1288. doi:10.1073/pnas.0510511103.</mixed-citation><mixed-citation xml:lang="en">Spees J.L., Olson S.D., Whitney M.J. et al. Mitochondrial transfer between cells can rescue aerobic respiration. Proceedings of the National Academy of Sciences, 2006, vol. 103, iss. 5, pp. 1283-1288. doi:10.1073/pnas.0510511103.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Sturgill-Koszycki S., Schlesinger P. H., Chakraborty P. et al. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase // Science. – 1994. – Vol. 263, Iss. 5147. – P. 678-681. doi: 10.1126/science.8303277.</mixed-citation><mixed-citation xml:lang="en">Sturgill-Koszycki S., Schlesinger P.H., Chakraborty P. et al. Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase. Science, 1994, vol. 263, iss. 5147, pp. 678-681. doi:10.1126/science.8303277.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tardif S., Ross C., Bergman P. et al. Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset // J. Gerontology Series A: Biomed. Sci. Med. Sci. – 2015. – Vol. 70, Iss. 5. – P. 577-588. doi:10.1093/gerona/glu101.</mixed-citation><mixed-citation xml:lang="en">Tardif S., Ross C., Bergman P. et al. Testing efficacy of administration of the antiaging drug rapamycin in a nonhuman primate, the common marmoset. J. Gerontology Series A: Biomed. Sci. Med. Sci., 2015, vol. 70, iss. 5, pp. 577-588. doi:10.1093/gerona/glu101.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Tropea K. A., Leder E., Aslam M. et al. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia // Amer. J. Physiology-Lung Cell. Molec. Physiol. – 2012. – Vol. 302, Iss. 9. – P. 829-837. doi:10.1152/ajplung.00347.2011.</mixed-citation><mixed-citation xml:lang="en">Tropea K.A., Leder E., Aslam M. et al. Bronchioalveolar stem cells increase after mesenchymal stromal cell treatment in a mouse model of bronchopulmonary dysplasia. Amer. J. Physiology-Lung Cell Molec. Physiol., 2012, vol. 302, iss. 9, pp. 829-837. doi:10.1152/ajplung.00347.2011.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">van der Wel N., Hava D., Houben D. et al. M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells // Cell. – 2007. – Vol. 129, Iss. 7. – P. 1287-1298. doi:10.1016/j.cell.2007.05.059.</mixed-citation><mixed-citation xml:lang="en">van der Wel N., Hava D., Houben D. et al. M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. Cell, 2007, vol. 129, iss. 7, pp. 1287-1298. doi:10.1016/j.cell.2007.05.059.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Velayati A. A. et al. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran // Chest. – 2009. – Vol. 136, Iss. 2. – P. 420-425. doi:10.1378/chest.08-2427.</mixed-citation><mixed-citation xml:lang="en">Velayati A.A. et al. Emergence of new forms of totally drug-resistant tuberculosis bacilli: super extensively drug-resistant tuberculosis or totally drug-resistant strains in Iran. Chest, 2009, vol. 136, iss. 2, pp. 420-425. doi:10.1378/chest.08-2427.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Wakamoto Y., Dhar N., Chait R. et al. Dynamic persistence of antibiotic-stressed mycobacteria // Science. – 2013. – Vol. 339, Iss. 6115. – P. 91-95. doi:10.1126/science.1229858.</mixed-citation><mixed-citation xml:lang="en">Wakamoto Y., Dhar N., Chait R. et al. Dynamic persistence of antibiotic-stressed mycobacteria. Science, 2013, vol. 339, iss. 6115, pp. 91-95. doi: 10.1126/science.1229858.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Yudintceva N. M., Bogolyubova I. O., Muraviov A. N. et al. Application of the allogenic mesenchymal stem cells in the therapy of the bladder tuberculosis // J. Tissue Eng. Regener. Med. – 2018. – Vol. 12, Iss. 3. – P. 1580-1593. doi:10.1002/term.2583.</mixed-citation><mixed-citation xml:lang="en">Yudintceva N.M., Bogolyubova I.O., Muraviov A.N. et al. Application of the allogenic mesenchymal stem cells in the therapy of the bladder tuberculosis. J. Tissue Eng. Regener. Med., 2018, vol. 12, iss. 3, pp. 1580-1593. doi:10.1002/term.2583.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
