<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tiblj</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и болезни легких</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and Lung Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-1230</issn><issn pub-type="epub">2542-1506</issn><publisher><publisher-name>Медицинские знания и технологии</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21292/2075-1230-2022-100-7-53-58</article-id><article-id custom-type="elpub" pub-id-type="custom">tiblj-1661</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ НАБЛЮДЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL OBSERVATIONS</subject></subj-group></article-categories><title-group><article-title>Милиарно-язвенный туберкулез полости рта у пациентки с туберкулезом легких на фоне ВИЧ-инфекции</article-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis Cutis Orificialis of the Oral Cavity in a HIV Positive Patient with Pulmonary Tuberculosis</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кукурика</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kukurika</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кукурика Анастасия Владимировна, врач-фтизиатр</p><p>г. Макеевка, ул. Сормовская, д. 7</p></bio><bio xml:lang="en"><p>Anastasia V. Kukurika, Phthisiologist</p><p>7, Sormovskaya St., Makeevka</p></bio><email xlink:type="simple">nastya_kukurika@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юровская</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Yurovskaya</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Юровская Екатерина Игоревна, врач-фтизиатр</p><p>г. Донецк, пр. Ильича, д. 104а</p></bio><bio xml:lang="en"><p>Ekaterina I. Yurovskaya, Phthisiologist</p><p>104a, Iliicha Ave., Donetsk</p></bio><email xlink:type="simple">doctorstoptb@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ляхимец</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Lyakhimets</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ляхимец Виктория Андреевна, врач-фтизиатр</p><p>г. Донецк, ул. Северная, д. 1</p></bio><bio xml:lang="en"><p>Viktoriya A. Lyakhimets, Phthisiologist</p><p>1, Severnaya St., Donetsk</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городской противотуберкулезный диспансер</institution><country>Украина</country></aff><aff xml:lang="en"><institution>Municipal TB Dispensary</institution><country>Ukraine</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Республиканская клиническая туберкулезная больница</institution><country>Украина</country></aff><aff xml:lang="en"><institution>Republican Clinical TB Hospital</institution><country>Ukraine</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>12</day><month>08</month><year>2022</year></pub-date><volume>100</volume><issue>7</issue><fpage>53</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кукурика А.В., Юровская Е.И., Ляхимец В.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Кукурика А.В., Юровская Е.И., Ляхимец В.А.</copyright-holder><copyright-holder xml:lang="en">Kukurika A.V., Yurovskaya E.I., Lyakhimets V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tibl-journal.com/jour/article/view/1661">https://www.tibl-journal.com/jour/article/view/1661</self-uri><abstract><p>Милиарно-язвенный туберкулез – редкая форма туберкулеза кожи. Приведены данные 5 клинических случаев милиарно-язвенного туберкулеза полости рта и губ, описанных в литературе. Представлено собственное клиническое наблюдение успешного излечения милиарно-язвенного туберкулеза полости рта, красной каймы губ и кожи нижней губы на фоне туберкулеза легких с множественной лекарственной устойчивостью у больной с ВИЧ-инфекцией. Сложность случая была обусловлена длительным диагностическим поиском (10 мес.), выраженной иммуносупрессией, лекарственной устойчивостью микобактерии туберкулеза.</p></abstract><trans-abstract xml:lang="en"><p>Tuberculosis cutis orificialis is a rare form of cutaneous tuberculosis. The article presents 5 clinical cases of tuberculosis cutis orificialis of the oral cavity and lips that were described in publications. We present our own clinical case of successful treatment of tuberculosis cutis orificialis of the oral cavity, red border of the lips and skin of the lower lip against the background of multiple drug resistant pulmonary tuberculosis in a HIV positive patient. The case was especially difficult due to a long diagnostic search (10 months), severe immunosuppression, and drug resistance of Mycobacterium tuberculosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулез кожи</kwd><kwd>милиарно-язвенный туберкулез</kwd><kwd>туберкулез с множественной лекарственной устойчивостью</kwd><kwd>ВИЧ-инфекция</kwd><kwd>дифференциальная диагностика</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cutaneous tuberculosis</kwd><kwd>tuberculosis cutis orificialis</kwd><kwd>multiple drug resistant tuberculosis</kwd><kwd>HIV infection</kwd><kwd>differential diagnosis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Арипова М. А., Хардикова С. А. Дифференциальная диагностика розацеа и туберкулеза кожи // Бюллетень сибирской медицины. ‒ 2014. ‒ Т. 13, № 5. ‒ С. 203-208.</mixed-citation><mixed-citation xml:lang="en">Aripova M.A., Khardikova S.A. Differential diagnosis of rosacea and cutaneous tuberculosis. Bulleten Sibirskoy Meditsiny, 2014, vol. 13, no. 5, pp. 203-208. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Заславский Д. В., Егорова Ю. С., Чупров И. Н. Оловянишников И. О., Гурковская Я. Ю., Сыдиков А. А. Чужов А. Л. Овчинникова Ю. Э., Довгалюк И. Ф. Старшинова А. Диссеминированный туберкулез кожи // Вестник дерматологии и венерологии. ‒ 2018. ‒ Т. 94, № 2. ‒ С. 69-77.</mixed-citation><mixed-citation xml:lang="en">Zaslavsky D.V., Egorova Yu.S., Chuprov I.N., Olovyanishnikov I.O., Gurkovskaya Ya.Yu., Sydikov A.A., Chuzhov A.L., Ovchinnikova Yu.E., Dovgalyuk I.F., Starshinova A. Disseminated cutaneous tuberculosis. Vestnik Dermatologii i Venerologii, 2018, vol. 94, no. 2, pp. 69-77. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кабулбекова А. А., Оспанова С. А., Омар А. У., Саздыкова Ж. А. Туберкулез кожи: проблемы диагностики // Вестник КазНМУ. ‒ 2012. ‒ № 1. С. 112-114.</mixed-citation><mixed-citation xml:lang="en">Kabulbekova A.A., Ospanova S.A., Omar A.U., Sazdykova Zh.A. Cutaneous tuberculosis: diagnostic challenges. Vestnik KazNMU, 2012, no. 1, pp. 112-114. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Куштан И. В., Грабовская О. В., Теплюк Н. П., Варшавский В. А., Гришина В. Б., Самойлова А. В. Сочетание лихеноидного и колликвативного туберкулеза кожи (скрофулодермы) // РМЖ. ‒ 2016. ‒ № 14. ‒ С. 954-957.</mixed-citation><mixed-citation xml:lang="en">Kushtan I.V., Grabovskaya O.V., Teplyuk N.P., Varshavskiy V.A., Grishina V.B., Самойлова А.В. Concurrent tuberculosis cutis lichenoides and tuberculosis cutis colliquativa. RMJ, 2016, no. 14, pp. 954-957. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Парпиева Н. Н., Саипова Н. С., Рахимов Д. Б., Мирадилова Ф. Б. Актуальные вопросы клиники и диагностики туберкулеза кожи // Туб. и болезни легких. – 2020. – Т. 98, № 10. – С. 52-57.</mixed-citation><mixed-citation xml:lang="en">Parpieva N.N., Saipova N.S., Rakhimov D.B., Miradilova F.B. The topical issues of symptoms and diagnosis of cutaneous tuberculosis. Tuberculosis and Lung Diseases, 2020, vol. 98, no. 10, pp. 52-57. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Полищук Д. С., Полищук С. И., Комарницкая В. С. Клинические случаи локализованных форм туберкулеза кожи // Украинский журнал дерматологии и венерологии, косметологии. ‒ 2014. ‒ Т. 52, № 1. ‒ С. 83-87.</mixed-citation><mixed-citation xml:lang="en">Polischuk D.S., Polischuk S.I., Komarnitskaya V.S. Clinical cases of local forms of cutaneous tuberculosis. Ukrainskiy Journal Dermatologii i Venerologii, Kosmetologii, 2014, vol. 52, no. 1, pp. 83-87. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Потейко П. И., Крутько В. С., Шевченко О. С., Ходош Э. М. Туберкулез кожи // Медицина неотложных состояний. ‒ 2012. ‒ Т. 46-47, № 7-8. С. 160-168.</mixed-citation><mixed-citation xml:lang="en">Poteyko P.I., Krutko V.S., Shevchenko O.S., Khodosh E.M. Cutaneous tuberculosis. Meditsina Neotlozhnykh Sostoyaniy, 2012, vol. 46-47, no. 7-8, pp. 160-168. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Тодорико Л. Д., Ильчишин Т. И. Клинический случай туберкулеза кожи // Туберкулез, легочные болезни, ВИЧ-инфекция. ‒ 2015. ‒ Т. 4, № 23. ‒ С. 121-124.</mixed-citation><mixed-citation xml:lang="en">Todoriko L.D., Ilchishin T.I. A clinical case of cutaneous tuberculosis. Tuberkulez, Legochnye Bolezni, VICH-Infektsiya, 2015, vol. 4, no. 23, pp. 121-124. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Agarwal P., Singh E. N., Agarwal U. S., Meena R., Purohit S., Kumar S. The role of DNA polymerase chain reaction, culture and histopathology in the diagnosis of cutaneous tuberculosis // Int. J. Dermatol. ‒ 2017. ‒ Vol. 56, № 11. ‒ P. 1119-1124.</mixed-citation><mixed-citation xml:lang="en">Agarwal P., Singh E.N., Agarwal U.S., Meena R., Purohit S., Kumar S. The role of DNA polymerase chain reaction, culture and histopathology in the diagnosis of cutaneous tuberculosis. Int. J. Dermatol., 2017, vol. 56, no. 11, pp. 1119-1124.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Arango-Ferreira C., Zapata-Muñoz C. M., Gotuzzo E. Cutaneous tuberculosis presenting as mastitis in a prepubertal girl // Am. J. Trop. Med. Hyg. ‒ 2018. Vol. 99, № 6. ‒ P. 1360-1361.</mixed-citation><mixed-citation xml:lang="en">Arango-Ferreira C., Zapata-Muñoz C.M., Gotuzzo E. Cutaneous tuberculosis presenting as mastitis in a prepubertal girl. Am. J. Trop. Med. Hyg., 2018, vol. 99, no. 6, pp. 1360-1361.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Asmaa S. H., Hassam B. Cutaneous tuberculosis with an unusual appearance and location // Pan. Afr. Med. J. ‒ 2019. ‒ № 32. ‒ P. 81.</mixed-citation><mixed-citation xml:lang="en">Asmaa S.H., Hassam B. Cutaneous tuberculosis with an unusual appearance and location. Pan. Afr. Med. J., 2019, no. 32, pp. 81.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Chauhan V., Mahesh D. M., Panda P., Mahajan S., Thakur S. Tuberculosis Cutis Orificialis (TBCO): a rare manifestation of tuberculosis // JAPI. ‒ 2012. Vol. 60. ‒ P. 48-49.</mixed-citation><mixed-citation xml:lang="en">Chauhan V., Mahesh D.M., Panda P., Mahajan S., Thakur S. Tuberculosis Cutis Orificialis (TBCO): a rare manifestation of tuberculosis. JAPI, 2012, vol. 60, pp. 48-49.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Dey B., Deshpande A. H., Bhat S. H., Singh A. Tuberculosis cutis orificialis with underlying pulmonary tuberculosis in an immunocompetent man // J. Lab. Physicians. ‒ 2018. ‒ Vol. 10, № 4. ‒ Р. 457-459.</mixed-citation><mixed-citation xml:lang="en">Dey B., Deshpande A.H., Bhat S.H., Singh A. Tuberculosis cutis orificialis with underlying pulmonary tuberculosis in an immunocompetent man. J. Lab. Physicians, 2018, vol. 10, no. 4, pp. 457-459.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Dicko A., Faye O., Fofana Y., Soumoutera M., Berthé S., Touré S., Traoré B., Guindo B., Tall K., Keita A., Kéita L., Coulibaly K., Keita S. Cutaneous tuberculosis in Bamako, Mali // Pan. Afr. Med. J. ‒ 2017. ‒ Vol. 8, № 27. ‒ P. 102.</mixed-citation><mixed-citation xml:lang="en">Dicko A., Faye O., Fofana Y., Soumoutera M., Berthé S., Touré S., Traoré B., Guindo B., Tall K., Keita A., Kéita L., Coulibaly K., Keita S. Cutaneous tuberculosis in Bamako, Mali. Pan. Afr. Med. J., 2017, vol. 8, no. 27, pp. 102.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Franco-Paredes C., Marcos L. A., Henao-Martínez A. F., Rodríguez-Morales A. J., Villamil-Gómez W. E., Gotuzzo E., Bonifaz A. Cutaneous mycobacterial infections // Clin. Microbiol. Rev. ‒ 2018. ‒ Vol. 32, № 1. ‒ e00069-18.</mixed-citation><mixed-citation xml:lang="en">Franco-Paredes C., Marcos L.A., Henao-Martínez A.F., Rodríguez-Morales A.J., Villamil-Gómez W.E., Gotuzzo E., Bonifaz A. Cutaneous mycobacterial infections. Clin. Microbiol. Rev., 2018, vol. 32, no. 1, e00069-18.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Gunawan H., Achdiat P. A., Hindritiani R., Essary E. D., Ningtias L. D., Siregar E. P., Sori P. R., Febrina D. Various cutaneous tuberculosis with rare clinical manifestations: A case series // Int. J. Mycobacteriol. ‒ 2018. ‒ Vol. 7, № 3. ‒ Р. 288-291.</mixed-citation><mixed-citation xml:lang="en">Gunawan H., Achdiat P.A., Hindritiani R., Essary E.D., Ningtias L.D., Siregar E.P., Sori P.R., Febrina D. Various cutaneous tuberculosis with rare clinical manifestations: A case series. Int. J. Mycobacteriol., 2018, vol. 7, no. 3, pp. 288-291.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Iskandarli M., Gerceker Turk B., Yaman B., Ceylan N., Ceylan C. Tuberculosis cutis orificialis in adalimumab related immunosupressive patient // Ann. Dermatol. ‒ 2017. ‒ Vol. 29, № 1. ‒ Р. 114-116.</mixed-citation><mixed-citation xml:lang="en">Iskandarli M., Gerceker Turk B., Yaman B., Ceylan N., Ceylan C. Tuberculosis cutis orificialis in adalimumab related immunosupressive patient. Ann. Dermatol., 2017, vol. 29, no. 1, pp. 114-116.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Mansfield B. S., Pieton K. Tuberculosis cutis orificialis // Open Forum Infect Dis. ‒ 2019. ‒ Vol. 30; 6 (10): ofz428.</mixed-citation><mixed-citation xml:lang="en">Mansfield B.S., Pieton K. Tuberculosis cutis orificialis. Open Forum Infect Dis., 2019, vol. 30; 6 (10): ofz428.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Morand J. J., Garnotel E., Simon F., Lightburn E. Cutaneous tuberculosis overview // Med. Trop. (Mars). ‒ 2006. ‒ Vol. 66, № 3. ‒ P. 229-236.</mixed-citation><mixed-citation xml:lang="en">Morand J.J., Garnotel E., Simon F., Lightburn E. Cutaneous tuberculosis overview. Med. Trop. (Mars), 2006, vol. 66, no. 3, pp. 229-236.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Santos J. B., Figueiredo A. R., Ferraz C. E., Oliveira M. H., Silva P. G., Medeiros V. L. S. Cutaneous tuberculosis: diagnosis, histopathology and treatment ‒ Part II // An. Bras. Dermatol. ‒ 2014. ‒ Vol. 89, № 4. ‒ Р. 545-555.</mixed-citation><mixed-citation xml:lang="en">Santos J.B., Figueiredo A.R., Ferraz C.E., Oliveira M.H., Silva P.G., Medeiros V.L.S. Cutaneous tuberculosis: diagnosis, histopathology and treatment. Part II. An. Bras. Dermatol., 2014, vol. 89, no. 4, pp. 545-555.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Sun W. L., Xu K. L., Chen L. L., Yu Z. S. Tuberculosis cutis orificialis with both gingival involvement and underlying pulmonary tuberculosis // Aust. Dent. J. ‒ 2011. ‒ Vol. 56, № 2. ‒ Р. 216-220.</mixed-citation><mixed-citation xml:lang="en">Sun W.L., Xu K.L., Chen L.L., Yu Z.S. Tuberculosis cutis orificialis with both gingival involvement and underlying pulmonary tuberculosis. Aust. Dent. J., 2011, vol. 56, no. 2, pp. 216-220.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
