tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2023-101-3-87-93tiblj-1735Research ArticleОБЗОРREVIEWСовременные методы профилактики ототоксичности аминогликозидов у больных туберкулезом легкихCurrent Methods of Prevention of Aminoglycoside Ototoxicity in Patients with Pulmonary TuberculosisСолохаА. А.SolokhaA. A.

Солоха Ангелина Андреевна, Младший научный сотрудник, врач-оториноларинголог 

630040, г. Новосибирск, ул. Охотская, 81а 

Angelina A. Solokha, Junior Researcher, Otorhinolaryngologist 

81a, Okhotskaya St., Novosibirsk, 630040 

81a, Okhotskaya St., Novosibirsk, 630040 

info@nsk-niit.ruСтавицкаяН. В.StavitskayaN. V.

Ставицкая Наталия Васильевна, Доктор медицинских наук, директор 

630040, г. Новосибирск, ул. Охотская, 81а 

Natalia V. Stavitskaya, Doctor of Medical Sciences, Director  

81a, Okhotskaya St., Novosibirsk, 630040 

info@nsk-niit.ruШварцЯ. Ш.ShvartsYa. Sh.

Шварц Яков Шмульевич, Доктор медицинских наук,  заместитель директора по научной работе

630040, г. Новосибирск, ул. Охотская, 81а 

Yakov Sh. Shvarts, Doctor of Medical Sciences, Deputy Director for Research

81a, Okhotskaya St., Novosibirsk, 630040 

СклюевС. В.SklyuevS. V.

Склюев Сергей Валерьевич, Заместитель главного врача по медицинской части

630040, г. Новосибирск, ул. Охотская, 81а 

Sergey V. Sklyuev, Deputy Chief Physician for Medical Activities

81a, Okhotskaya St., Novosibirsk, 630040 

ТурсуноваН. В.TursunovaN. V.

Турсунова Наталья Владимировна, Ведущий научный сотрудник

630040, г. Новосибирск, ул. Охотская, 81а 

Natalia V. Tursunova, Leading Researcher

81a, Okhotskaya St., Novosibirsk, 630040 

natalya-tursunova@mail.ruФГБУ «Новосибирский научно-исследовательский институт туберкулеза» МЗ РФРоссияNovosibirsk Tuberculosis Research Institute, Russian Ministry of HealthRussian Federation202304072023101387–93Copyright © Солоха А.А., Ставицкая Н.В., Шварц Я.Ш., Склюев С.В., Турсунова Н.В., 20232023Солоха А.А., Ставицкая Н.В., Шварц Я.Ш., Склюев С.В., Турсунова Н.В.Solokha A.A., Stavitskaya N.V., Shvarts Y.S., Sklyuev S.V., Tursunova N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1735

Проведен анализ современной литературы о возможности медикаментозной коррекции ототоксических эффектов аминогликозидов. Наиболее перспективными в данном аспекте представляются вещества с антиоксидантным действием. Их применение в терапевтических дозах не сопровождается нежелательными побочными эффектами, они не влияют на антибактериальное действие противотуберкулезных препаратов. В настоящее время изучаются механизмы отопротекторного действия различных антиоксидантов.

Contemporary publications on possible pharmaceutical treatment of ototoxic effect of aminoglycosides have been analyzed. In this respect, substances with the antioxidant effect seem to be the most promising. Their use in therapeutic doses is not accompanied by adverse reactions, and they do not interfere with the antibacterial effect of anti-tuberculosis drugs. Currently, the mechanisms of the otoprotective action of various antioxidants are being studied.

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The authors declare that there are no conflicts of interest present.