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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tiblj</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и болезни легких</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and Lung Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-1230</issn><issn pub-type="epub">2542-1506</issn><publisher><publisher-name>Медицинские знания и технологии</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.58838/2075-1230-2024-102-1-82-86</article-id><article-id custom-type="elpub" pub-id-type="custom">tiblj-1798</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>Применение ингаляционных антибиотиков как одна из мер борьбы с резистентностью бактерий (на примере кистозного фиброза)</article-title><trans-title-group xml:lang="en"><trans-title>Treatment with Inhaled Antibiotics as One of the Measures to Combat Bacterial Resistance (Cystic Fibrosis is Used as an Example)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тахтамышева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Takhtamysheva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Тахтамышева Анна Валентиновна, врач-терапевт</p><p>283005, г. Донецк, ул. Диккенса, 1 </p></bio><bio xml:lang="en"><p>Anna V. Takhtamysheva, General Practitioner</p><p>1 Dikkens St., Donetsk, 283005</p></bio><email xlink:type="simple">a.takhtamysheva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУ «Центр первичной медико-санитарной помощи № 9 г. Донецка»</institution><country>ДНР</country></aff><aff xml:lang="en"><institution>Donetsk Center for Primary Medical Sanitary Care no. 9</institution><country>DNR</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>20</day><month>03</month><year>2024</year></pub-date><volume>102</volume><issue>1</issue><fpage>82</fpage><lpage>86</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Тахтамышева А.В., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Тахтамышева А.В.</copyright-holder><copyright-holder xml:lang="en">Takhtamysheva A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tibl-journal.com/jour/article/view/1798">https://www.tibl-journal.com/jour/article/view/1798</self-uri><abstract><p>В представленном обзоре анализируется 33 источника литературы по эффективности ингаляционных антибиотиков у пациентов с кистозным фиброзом и определению их влияния на резистентность бактерий.</p></abstract><trans-abstract xml:lang="en"><p>This review analyzes 33 publications on the effectiveness of inhaled antibiotics in patients with cystic fibrosis and evaluates their effect on bacterial resistance.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ингаляционные антибиотики</kwd><kwd>муковисцидоз</kwd><kwd>кистозный фиброз</kwd><kwd>резистентность бактерий</kwd></kwd-group><kwd-group xml:lang="en"><kwd>inhaled antibiotics</kwd><kwd>cystic fibrosis</kwd><kwd>bacterial resistance</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Клинические рекомендации по ведению пациентов с кистозным фиброзом (муковисцидозом). Москва; 2021. URL: https://cr.minzdrav.gov.ru/recomend/372_2 [Дата обращения 10 декабря 2023г.]</mixed-citation><mixed-citation xml:lang="en">Klinicheskiye rekomendatsii po vedeniyu patsiyentov s kistoznym fibrozom (mukovistsidozom). [Guidelines on management of cystic fibrosis patients]. Moscow, 2021. Available: https://cr.minzdrav.gov.ru/recomend/372_2 Accessed December 10, 2023.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Кузовлев А. Н., Мороз В. В., Голубев А. М., Половников С. Г. Ингаляционные антибиотики в лечении тяжелой нозокомиальной пневмонии / // Общая реаниматология. – 2013. – Т. 9. – № 6. – С. 61-70. https://doi.org/10.15360/1813-9779-2013-6-61</mixed-citation><mixed-citation xml:lang="en">Kuzovlev A.N., Moroz V.V., Golubev A.M., Polovnikov S.G. Inhaled antibiotics in the treatment of nosocomial pneumonia. Obschaya Reanimatologiya, 2013, vol. 9, no. 6, pp. 61-70. (In Russ.) https://doi.org/10.15360/1813-9779-2013-6-61</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Чукина М. А., Лукина М. В., Андрущишина Т. Б., и др. Ингаляционное применение амикацина у пациентов с нозокомиальной пневмонией в отделении интенсивной терапии // Вестник Смоленской государственной медицинской академии. – 2019. – Т. 18. – № 1. – С. 137-144.</mixed-citation><mixed-citation xml:lang="en">Chukina M.A., Lukina M.V., Andruschishina T.B. et al. Inhaled amikacin in patients with nosocomial pneumonia in the intensive care unit. Vestnik Smolenskoy Gosudarstvennoy Meditsinskoy Akademii, 2019, vol. 18, no. 1, pp. 137-144. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bassetti M., Luyt C.E., Nicolau D.P., Pugin J. Characteristics of an ideal nebulized antibiotic for the treatment of pneumonia in the intubated patient // Ann Intensive Care. – 2016. – Vol.6, № 1. – Р.35. https://doi.org/10.1186/s13613-016-0140-x PMID: 27090532</mixed-citation><mixed-citation xml:lang="en">Bassetti M., Luyt C.E., Nicolau D.P., Pugin J. Characteristics of an ideal nebulized antibiotic for the treatment of pneumonia in the intubated patient. Ann. Intensive Care, 2016, vol. 6, no. 1, pp. 35. https://doi.org/10.1186/s13613-016-0140-x PMID: 27090532</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Choi J., Novak K., Thompson R. Evaluation of Inhaled Tobramycin in Early Eradication of Pseudomonas aeruginosa in Infants With Cystic Fibrosis // J Pediatr Pharmacol Ther. – 2020. – Vol 25, №8. – Р.709-716. https://doi.org/10.5863/1551-6776-25.8.709 PMID: 33214782</mixed-citation><mixed-citation xml:lang="en">Choi J., Novak K., Thompson R. Evaluation of inhaled tobramycin in early eradication of Pseudomonas aeruginosa in infants with cystic fibrosis. J. Pediatr. Pharmacol. Ther., 2020, vol. 25, no. 8, pp. 709-716. https://doi.org/10.5863/1551-6776-25.8.709 PMID: 33214782</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">ClinicalTrials.gov: NCT01270347 Trial of Aeroquin Versus Tobramycin Inhalation Solution (TIS) in Cystic Fibrosis (CF) Patients (TIS) Available at: https://ichgcp.net/clinical-trials-registry/NCT01270347 [Accessed 15 Dec 2022].</mixed-citation><mixed-citation xml:lang="en">ClinicalTrials.gov: NCT01270347 Trial of aeroquin versus tobramycin inhalation solution (TIS) in cystic fibrosis (CF) patients (TIS). Available: ehttps://ichgcp.net/clinical-trials-registry/NCT01270347 Accessed December 15, 2022</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Daniels T., Mills N., Whitaker P. Nebuliser systems for drug delivery in cystic fibrosis // Cochrane Database Syst Rev. – 2013. – Vol.30, № 4. – Р.CD007639. https://doi.org/10.1002/14651858 PMID:23633344</mixed-citation><mixed-citation xml:lang="en">Daniels T., Mills N., Whitaker P. Nebuliser systems for drug delivery in cystic fibrosis. Cochrane Database Syst. Rev., 2013, vol. 30, no. 4, pp. CD007639. https://doi.org/10.1002/14651858 PMID:23633344</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Dasenbrook E.C., Konstan M.W., VanDevanter D.R. Association between the introduction of a new cystic fibrosis inhaled antibiotic class and change in prevalence of patients receiving multiple inhaled antibiotic classes // J Cyst Fibros. – 2015. – Vol.14, №3. – Р.370-5. https://doi.org/10.1016/j.jcf.2014.11.005 PMID: 25496726</mixed-citation><mixed-citation xml:lang="en">Dasenbrook E.C., Konstan M.W., VanDevanter D.R. Association between the introduction of a new cystic fibrosis inhaled antibiotic class and change in prevalence of patients receiving multiple inhaled antibiotic classes. J. Cyst. Fibros., 2015, vol. 14, no. 3, pp. 370-5. https://doi.org/10.1016/j.jcf.2014.11.005 PMID: 25496726</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dezube R., Jennings M.T., Rykiel M., Diener-West M., Boyle M.P., Chmiel J.F., Dasenbrook E.C. Eradication of persistent methicillin-resistant Staphylococcus aureus infection in cystic fibrosis // J Cyst Fibros. – 2019. – Vol.18, №3. – Р.357-363. https://doi.org/10.1016/j.jcf.2018.07.005 PMID: 30131297</mixed-citation><mixed-citation xml:lang="en">Dezube R., Jennings M.T., Rykiel M., Diener-West M., Boyle M.P., Chmiel J.F., Dasenbrook E.C. Eradication of persistent methicillin-resistant Staphylococcus aureus infection in cystic fibrosis. J. Cyst. Fibros., 2019, vol. 18, no. 3, pp. 357-363. https://doi.org/10.1016/j.jcf.2018.07.005 PMID: 30131297</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Ekkelenkamp M.B., Díez-Aguilar M., Tunney M.M., Elborn J.S., Fluit A.C., Cantón R. Establishing Antimicrobial Susceptibility Testing Methods and Clinical Breakpoints for Inhaled Antibiotic Therapy // Open Forum Infect Dis. // 2022. – Vol.9,№4. – Р.ofac082. https://doi.org/10.1093/ofid/ofac082 PMID: 35265731</mixed-citation><mixed-citation xml:lang="en">Ekkelenkamp M.B., Díez-Aguilar M., Tunney M.M., Elborn J.S., Fluit A.C., Cantón R. Establishing antimicrobial susceptibility testing methods and clinical breakpoints for inhaled antibiotic therapy. Open Forum Infect. Dis., 2022, vol. 9, no. 4, pp. ofac082. https://doi.org/10.1093/ofid/ofac082 PMID: 35265731</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Elborn J.S., Flume P.A., Cohen F., Loutit J., VanDevanter D.R. Safety and efficacy of prolonged levofloxacin inhalation solution (APT-1026) treatment for cystic fibrosis and chronic Pseudomonas aeruginosa airway infection // J Cyst Fibros. – 2016. – Vol.15, №5. – Р.634-40. https://doi.org/10.1016/j.jcf.2016.01.005 PMID: 26935334</mixed-citation><mixed-citation xml:lang="en">Elborn J.S., Flume P.A., Cohen F., Loutit J., VanDevanter D.R. Safety and efficacy of prolonged levofloxacin inhalation solution (APT-1026) treatment for cystic fibrosis and chronic Pseudomonas aeruginosa airway infection. J. Cyst. Fibros., 2016, vol. 15, no. 5, pp. 634-40. https://doi.org/10.1016/j.jcf.2016.01.005 PMID: 26935334</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Goetz D., Ren C.L. Review of Cystic Fibrosis // Pediatr Ann. – 2019. – Vol.48,№4. –Р.e154-e161. https://doi.org/10.3928/19382359-20190327-01 PMID: 30986316</mixed-citation><mixed-citation xml:lang="en">Goetz D., Ren C.L. Review of cystic fibrosis. Pediatr. Ann., 2019, vol. 48, no. 4, pp. e154-e161. https://doi.org/10.3928/19382359-20190327-01 PMID: 30986316</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hatziagorou E., Orenti A., Drevinek P., Kashirskaya N., Mei-Zahav M., De Boeck K; ECFSPR. Electronic address: ECFS-Patient.Registry@uz.kuleuven. ac.be; ECFSPR. Changing epidemiology of the respiratory bacteriology of patients with cystic fibrosis-data from the European cystic fibrosis society patient registry // J Cyst Fibros. –2020. – Vol.19, № 3. – Р.376-383. https://doi.org/10.1016/j.jcf.2019.08.006 PMID: 31492646</mixed-citation><mixed-citation xml:lang="en">Hatziagorou E., Orenti A., Drevinek P., Kashirskaya N., Mei-Zahav M., De Boeck K; ECFSPR. Changing epidemiology of the respiratory bacteriology of patients with cystic fibrosis-data from the European cystic fibrosis society patient registry. J. Cyst. Fibros., 2020, vol. 19, no. 3, pp. 376-383. https://doi.org/10.1016/j.jcf.2019.08.006 PMID: 31492646</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Henriette Zweijpfenning S.M., Chiron R., Essink S., Schildkraut J., Akkerman O.W., Aliberti S., Altenburg J., Arets B., van Braeckel E., Delaere B., Gohy S., Haarman E., Lorent N., McKew G., Morgan L., Wagner D., van Ingen J., Hoefsloot W. Safety and Outcomes of Amikacin Liposome Inhalation Suspension for Mycobacterium abscessus Pulmonary Disease: A NTM-NET study // Chest. – 2022. – Vol.162, №1. –Р.76-81. https://doi.org/10.1016/j.chest.2022.01.015 PMID: 35063454</mixed-citation><mixed-citation xml:lang="en">Henriette Zweijpfenning S.M., Chiron R., Essink S., Schildkraut J., Akkerman O.W., Aliberti S., Altenburg J., Arets B., van Braeckel E., Delaere B., Gohy S., Haarman E., Lorent N., McKew G., Morgan L., Wagner D., van Ingen J., Hoefsloot W. Safety and outcomes of amikacin liposome inhalation suspension for Mycobacterium abscessus pulmonary disease: A NTM-NET study. Chest, 2022, vol. 162, no. 1, pp. 76-81. https://doi.org/10.1016/j.chest.2022.01.015 PMID: 35063454</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Hoo Z.H., Curley R., Campbell M.J., Walters S.J., Hind D., Wildman MJ. Accurate reporting of adherence to inhaled therapies in adults with cystic fibrosis: methods to calculate "normative adherence" // Patient Prefer Adherence. – 2016. – Vol. 23, №10. –Р.887-900. https://doi.org/10.2147/PPA.S105530 PMID: 27284242</mixed-citation><mixed-citation xml:lang="en">Hoo Z.H., Curley R., Campbell M.J., Walters S.J., Hind D., Wildman MJ. Accurate reporting of adherence to inhaled therapies in adults with cystic fibrosis: methods to calculate "normative adherence". Patient Prefer Adherence, 2016, vol. 23, no. 10, pp. 887-900. https://doi.org/10.2147/PPA.S105530 PMID: 27284242</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Jennings M.T., Boyle M.P., Weaver D., Callahan K.A., Dasenbrook E.C. Eradication strategy for persistent methicillin-resistant Staphylococcus aureus infection in individuals with cystic fibrosis--the PMEP trial: study protocol for a randomized controlled trial // Trials. –2014. –№ 15. – Р.223. https://doi.org/10.1186/1745-6215-15-223 PMID: 24925006</mixed-citation><mixed-citation xml:lang="en">Jennings M.T., Boyle M.P., Weaver D., Callahan K.A., Dasenbrook E.C. Eradication strategy for persistent methicillin-resistant Staphylococcus aureus infection in individuals with cystic fibrosis – the PMEP trial: study protocol for a randomized controlled trial. Trials, 2014, no. 15, pp. 223. https://doi.org/10.1186/1745-6215-15-223 PMID: 24925006</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Jones L.A., Doucette L., Dellon E.P., Esther C.R., McKinzie C.J. Use of inhaled imipenem/cilastatin in pediatric patients with cystic fibrosis: A case series // J Cyst Fibros. – 2019. – Vol.18, №4. – e42-e44. https://doi.org/10.1016/j.jcf.2019.04.017 PMID: 31060800</mixed-citation><mixed-citation xml:lang="en">Jones L.A., Doucette L., Dellon E.P., Esther C.R., McKinzie C.J. Use of inhaled imipenem/cilastatin in pediatric patients with cystic fibrosis: A case series. J. Cyst. Fibros., 2019, vol. 18, no. 4, pp. e42-e44. https://doi.org/10.1016/j.jcf.2019.04.017 PMID: 31060800</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Karampitsakos T., Papaioannou O., Kaponi M., Kozanidou A., Hillas G., Stavropoulou E., Bouros D., Dimakou K. Low penetrance of antibiotics in the epithelial lining fluid. The role of inhaled antibiotics in patients with bronchiectasis // Pulm Pharmacol Ther. – 2020. – №60. – Р.101885. https://doi.org/10.1016/j.pupt.2019.101885 PMID: 31891761.</mixed-citation><mixed-citation xml:lang="en">Karampitsakos T., Papaioannou O., Kaponi M., Kozanidou A., Hillas G., Stavropoulou E., Bouros D., Dimakou K. Low penetrance of antibiotics in the epithelial lining fluid. The role of inhaled antibiotics in patients with bronchiectasis. Pulm. Pharmacol. Ther., 2020, no. 60, pp. 101885. https://doi.org/10.1016/j.pupt.2019.101885 PMID: 31891761</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Kiefer A., Bogdan C., Melichar V.O. Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme // BMC Pulm Med. – 2018. – Vol.18, №1. –Р.20. https://doi.org/10.1186/s12890-018-0588-6 PMID: 29370836</mixed-citation><mixed-citation xml:lang="en">Kiefer A., Bogdan C., Melichar V.O. Successful eradication of newly acquired MRSA in six of seven patients with cystic fibrosis applying a short-term local and systemic antibiotic scheme. BMC Pulm. Med., 2018, vol. 18, no. 1, pp. 20. https://doi.org/10.1186/s12890-018-0588-6 PMID: 29370836</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kuzovlev, A. N. Inhaled Antibiotics in Reanimatology: Problem State and Development Prospects (Review) / A. N. Kuzovlev, A. V. Grechko // General Reanimatology. – 2017. – Vol. 13. – № 5. – P. 69-84. https://doi.org/10.15360/1813-9779-2017-5-69-84</mixed-citation><mixed-citation xml:lang="en">Kuzovlev A.N. Inhaled Antibiotics in Reanimatology: Problem State and Development Prospects (Review). A.N. Kuzovlev, A.V. Grechko. General Reanimatology, 2017, vol. 13, no. 5, pp. 69-84. https://doi.org/10.15360/1813-9779-2017-5-69-84</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Langton Hewer S.C., Smyth A.R. Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis // Cochrane Database Syst Rev. – 2017. – Vol. 4, №4. – Р.CD004197. https://doi.org/10.1002/14651858.CD004197.pub5 PMID: 28440853</mixed-citation><mixed-citation xml:lang="en">Langton Hewer S.C., Smyth A.R. Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis. Cochrane Database Syst. Rev., 2017, vol. 4, no. 4, pp. CD004197. https://doi.org/10.1002/14651858.CD004197.pub5 PMID: 28440853</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Lebeaux D., Chauhan A., Rendueles O., Beloin C. From in vitro to in vivo Models of Bacterial Biofilm-Related Infections // Pathogens. –2013. – Vol 2, № 2. – Р.288-356. https://doi.org/10.3390/pathogens2020288 PMID: 25437038</mixed-citation><mixed-citation xml:lang="en">Lebeaux D., Chauhan A., Rendueles O., Beloin C. From in vitro to in vivo Models of Bacterial Biofilm-Related Infections. Pathogens, 2013, vol. 2, no. 2, pp. 288-356. https://doi.org/10.3390/pathogens2020288 PMID: 25437038</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Lebeaux D., Ghigo J.M., Beloin C. Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics // Microbiol Mol Biol Rev. – 2014. – Vol.78, 3. –Р. 510-43. https://doi.org/10.1128/MMBR.00013-14 PMID: 25184564</mixed-citation><mixed-citation xml:lang="en">Lebeaux D., Ghigo J.M., Beloin C. Biofilm-related infections: bridging the gap between clinical management and fundamental aspects of recalcitrance toward antibiotics. Microbiol. Mol. Biol. Rev., 2014, vol. 78, 3. pp. 510-43. https://doi.org/10.1128/MMBR.00013-14 PMID: 25184564</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Møller R., Nielsen B.U., Faurholt-Jepsen D., Katzenstein T.L., Skov M., Philipsen L.KD, Pressler T., Johansen H.K, Qvist T. Use of inhaled antibiotics among Danish patients with cystic fibrosis // Pediatr Pulmonol. – 2022. – Vol.57, №7. – Р.1726-1734. https://doi.org/10.1002/ppul.25942 PMID: 35478387</mixed-citation><mixed-citation xml:lang="en">Møller R., Nielsen B.U., Faurholt-Jepsen D., Katzenstein T.L., Skov M., Philipsen L.KD, Pressler T., Johansen H.K, Qvist T. Use of inhaled antibiotics among Danish patients with cystic fibrosis. Pediatr. Pulmonol., 2022, vol. 57, no. 7, pp. 1726-1734. https://doi.org/10.1002/ppul.25942 PMID: 35478387</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Quon B.S., Goss C.H., Ramsey B.W. Inhaled antibiotics for lower airway infections // Ann Am Thorac Soc. – 2014. – Vol.11, № 3. – Р.425-34. https://doi.org/10.1513/AnnalsATS.201311-395FR PMID: 24673698</mixed-citation><mixed-citation xml:lang="en">Quon B.S., Goss C.H., Ramsey B.W. Inhaled antibiotics for lower airway infections. Ann. Am. Thorac. Soc., 2014, vol. 11, no. 3, pp. 425-34. https://doi.org/10.1513/AnnalsATS.201311-395FR PMID: 24673698</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Riveiro V., Casal A., Álvarez-Dobaño J.M., Lourido T., Suárez-Artime P., Rodríguez-García C., Ferreiro L., Toubes M.E., Valdés L. Response to inhaled ceftazidime in patients with non-cystic fibrosis bronchiectasis and chronic bronchial infection unrelated to Pseudomonas aeruginosa.– Clin Respir J. – 2022. – Vol. 16, №11.</mixed-citation><mixed-citation xml:lang="en">Riveiro V., Casal A., Álvarez-Dobaño J.M., Lourido T., Suárez-Artime P., Rodríguez-García C., Ferreiro L., Toubes M.E., Valdés L. Response to inhaled ceftazidime in patients with non-cystic fibrosis bronchiectasis and chronic bronchial infection unrelated to Pseudomonas aeruginosa. Clin. Respir. J., 2022, vol. 16, no. 11, pp. 768-773. https://doi.org/10.1111/crj.13534 PMID: 36017771</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Stockmann C., Sherwin C.M., Ampofo K., Spigarelli M.G. Development of levofloxacin inhalation solution to treat Pseudomonas aeruginosa in patients with cystic fibrosis // Ther Adv Respir Dis. – 2014. – Vol.8, № 1. – Р. 13-21. https://doi.org/10.1177/1753465813508445 PMID: 24334337</mixed-citation><mixed-citation xml:lang="en">Stockmann C., Sherwin C.M., Ampofo K., Spigarelli M.G. Development of levofloxacin inhalation solution to treat Pseudomonas aeruginosa in patients with cystic fibrosis. Ther. Adv. Respir. Dis., 2014, vol. 8, no. 1, pp. 13-21. https://doi.org/10.1177/1753465813508445 PMID: 24334337</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Tiddens H.A., Bos A.C., Mouton J.W., Devadason S., Janssens H.M. Inhaled antibiotics: dry or wet? // Eur Respir J. – 2014. – Vol.44, № 5. – Р.1308-18. https://doi.org/10.1183/09031936.00090314 PMID: 25323242.</mixed-citation><mixed-citation xml:lang="en">Tiddens H.A., Bos A.C., Mouton J.W., Devadason S., Janssens H.M. Inhaled antibiotics: dry or wet? Eur. Respir. J., 2014, vol. 44, no. 5, pp. 1308-18. https://doi.org/10.1183/09031936.00090314 PMID: 25323242</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Vázquez-Espinosa E., Girón R.M., Gómez-Punter R.M., García-Castillo E., Valenzuela C., Cisneros C., Zamora E., García-Pérez F..J, Ancochea J. Long-term safety and efficacy of tobramycin in the management of cystic fibrosis // Ther Clin Risk Manag. – 2015. –№ 11. – Р.407-15. https://doi.org/10.2147/TCRM.S75208 PMID: 25792839</mixed-citation><mixed-citation xml:lang="en">Vázquez-Espinosa E., Girón R.M., Gómez-Punter R.M., García-Castillo E., Valenzuela C., Cisneros C., Zamora E., García-Pérez F.J., Ancochea J. Long-term safety and efficacy of tobramycin in the management of cystic fibrosis. Ther. Clin. Risk Manag., 2015, no. 11, pp. 407-15. https://doi.org/10.2147/TCRM.S75208 PMID: 25792839</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Wang M., Ridderberg W., Hansen C.R., Høiby N., Jensen-Fangel S., Olesen H.V., Skov M., Lemming L.E., Pressler T., Johansen H.K., Nørskov-Lauritsen N. Early treatment with inhaled antibiotics postpones next occurrence of Achromobacter in cystic fibrosis // J Cyst Fibros. – 2013. – Vol.12, № 6. – Р. 638-43. https://doi.org/10.1016/j.jcf.2013.04.013 PMID: 23727271</mixed-citation><mixed-citation xml:lang="en">Wang M., Ridderberg W., Hansen C.R., Høiby N., Jensen-Fangel S., Olesen H.V., Skov M., Lemming L.E., Pressler T., Johansen H.K., Nørskov-Lauritsen N. Early treatment with inhaled antibiotics postpones next occurrence of Achromobacter in cystic fibrosis. J. Cyst. Fibros., 2013, vol. 12, no. 6, pp. 638-43. https://doi.org/10.1016/j.jcf.2013.04.013 PMID: 23727271</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Weldrick P.J., Hardman M.J., Paunov V.N. Enhanced Clearing of Wound-Related Pathogenic Bacterial Biofilms Using Protease-Functionalized Antibiotic Nanocarriers // ACS Appl Mater Interfaces. – 2019. – Vol.11, 47. – Р.43902-43919. https://doi.org/10.1021/acsami.9b16119 PMID: 31718141</mixed-citation><mixed-citation xml:lang="en">Weldrick P.J., Hardman M.J., Paunov V.N. Enhanced Clearing of Wound-Related Pathogenic Bacterial Biofilms Using Protease-Functionalized Antibiotic Nanocarriers. ACS Appl. Mater. Interfaces, 2019, vol. 11, 47. pp. 43902-43919. https://doi.org/10.1021/acsami.9b16119 PMID: 31718141</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">White L., Mirrani G., Grover M., Rollason J., Malin A., Suntharalingam J. Outcomes of Pseudomonas eradication therapy in patients with non-cystic fibrosis bronchiectasis // Respir Med. – 2012. – Vol. 106, № 3. – Р.356-60. https://doi.org/10.1016/j.rmed.2011.11.018 PMID: 22204744.</mixed-citation><mixed-citation xml:lang="en">White L., Mirrani G., Grover M., Rollason J., Malin A., Suntharalingam J. Outcomes of Pseudomonas eradication therapy in patients with non-cystic fibrosis bronchiectasis. Respir. Med., 2012, vol. 106, no. 3, pp. 356-60. https://doi.org/10.1016/j.rmed.2011.11.018 PMID: 22204744</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Zobell J.T., Epps K.L., Young D.C., Montague M., Olson J., Ampofo K., Chin M.J., Marshall B.C., Dasenbrook E. Utilization of antibiotics for methicillin-resistant Staphylococcus aureus infection in cystic fibrosis // Pediatr Pulmonol. – 2015. – Vol. 50, №6. – Р. 552-9. https://doi.org/10.1002/ppul.23132 PMID: 25559432</mixed-citation><mixed-citation xml:lang="en">Zobell J.T., Epps K.L., Young D.C., Montague M., Olson J., Ampofo K., Chin M.J., Marshall B.C., Dasenbrook E. Utilization of antibiotics for methicillin-resistant Staphylococcus aureus infection in cystic fibrosis. Pediatr. Pulmonol., 2015, vol. 50, vol. 6, pp. 552-9. https://doi.org/10.1002/ppul.23132 PMID: 25559432</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
