tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2024-102-2-6-19tiblj-1799Research ArticleВСЕМИРНЫЙ ДЕНЬ БОРЬБЫ С ТУБЕРКУЛЕЗОМWORLD TUBERCULOSIS DAY100 лет вакцинации против туберкулеза – уроки и перспективы100 Years of Vaccination against Tuberculosis – Lessons Learnt and Prospectshttps://orcid.org/0000-0003-4552-5022БогородскаяЕ. М.BogorodskayaE. M.

Богородская Елена Михайловна, доктор медицинских наук, профессор, директор, заведующая кафедрой фтизиатрии

107014, Москва, ул. Стромынка, д. 10

Тел.: + 7 (499) 268-00-05

Elena M. Bogorodskaya, Doctor of Medical Sciences, Professor, Director, Head of Phthisiology Department

10 Stromynka St., Moscow, 107014

Phone: + 7 (499) 268-00-05

el_bogorodskaya@mail.ruhttps://orcid.org/0000-0003-1878-4467КудлайД. А.KudlayD. A.

Кудлай Дмитрий Анатольевич, член-корреспондент РАН, доктор медицинских наук, профессор кафедры фармакологии Института фармации, профессор кафедры фармакогнозии и промышленной фармации факультета фундаментальной медицины; ведущий научный сотрудник лаборатории персонализированной медицины и молекулярной иммунологии

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

Тел. +7 (499) 248-05-53

Dmitry A. Kudlay, Correspondent Member of RAS, Doctor of Medical Sciences, Professor of Pharmacology Department of Pharmacy Institute, Professor of Department of Pharmacognosy and Industrial Pharmacy, Faculty of Fundamental Medicine; Leading Researcher of Laboratory of Personalized Medicine and Molecular Immunology

8 Bd. 2, Trubetskaya St., Russia Moscow, 119991

Phone: +7 (499) 248-05-53

d624254@gmail.comhttps://orcid.org/0000-0001-9956-2385СлогоцкаяЛ. В.SlogotskayaL. V.

Слогоцкая Людмила Владимировна, доктор медицинских наук, заведующая научно-клиническим отделом, профессор кафедры фтизиатрии

107014, Москва, ул. Стромынка, д. 10

Тел.: + 7 (499) 268-00-05

Ludmila V. Slogotskaya, Doctor of Medical Sciences, Head of Research Clinical Department, Professor of Phthisiology Department

10 Stromynka St., Moscow, 107014

Phone: + 7 (499) 268-00-05

lyu186@yandex.ruГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФРоссияMoscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health; Russian Medical Academy of On-going Professional Education, Russian Ministry of HealthRussian FederationФГАОУ ВО «Первый МГМУ им. И. М. Сеченова (Сеченовский Университет)» МЗ РФ; ФГБОУ ВПО «Московский государственный университет имени М.В.Ломоносова»; ФГБУ «ГНЦ Институт иммунологии ФМБА России»РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health; Lomonosov Moscow State University; Immunology Research Institute by the Russian Federal Medical Biological AgencyRussian FederationГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»; ФГБОУ ДПО «Российская медицинская академия непрерывного профессионального образования» МЗ РФРоссияMoscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of Health; Russian Medical Academy of On-going Professional Education, Russian Ministry of HealthRussian Federation2024290420241022619Copyright © Богородская Е.М., Кудлай Д.А., Слогоцкая Л.В., 20242024Богородская Е.М., Кудлай Д.А., Слогоцкая Л.В.Bogorodskaya E.M., Kudlay D.A., Slogotskaya L.V.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1799

Представлен обзор литературы, посвященный 100-летию внедрения противотуберкулезной вакцины БЦЖ, основанный на анализе 83 публикаций отечественных и зарубежных авторов. Дана оценка результатов применения вакцины БЦЖ в разных клинических исследованиях и реальной клинической практике. Приведены данные о создании новых вакцин-кандидатов, механизмы их воздействия на различные звенья иммунитета. Особый интерес представляют вакцины-кандидаты не только профилактические, применяемые до первого контакта с инфекцией у младенцев, но и терапевтические, которые направлены на лечебный эффект при туберкулезе и латентной туберкулезной инфекции.

The article presents a literature review dedicated to the 100th anniversary of introduction of the BCG vaccine against tuberculosis; it analyzes of 83 publications by Russian and foreign authors. The results of the BCG vaccination used in various clinical studies and real clinical practice are assessed. The article presents data on development of new candidate vaccines and mechanisms of their effect on various parts of the immune system. Candidate vaccines are of particular interest, these candidate vaccines are used not only for prevention before infants are exposed to the infection for the first time, but also for therapy, the vaccines are aimed at therapeutic action against tuberculosis and latent tuberculosis infection.

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The authors declare that there are no conflicts of interest present.