tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2024-102-2-86-96tiblj-1808Research ArticleОБЗОРREVIEWКишечная микробиота и туберкулез легких (обзор литературы)Gut Microbiota and Pulmonary Tuberculosis (Literature Review)https://orcid.org/0000-0002-9455-5597ЮхименкоН. В.YukhimenkoN. V.

Юхименко Наталья Валентиновна, д.м.н., ведущий научный сотрудник детско-подросткового отдела

107564, г. Москва, ул. Яузская аллея, д. 2

Тел.: +7 (499) 785-90-27

Natalya V. Yukhimenko, Doctor of Medical Sciences, Leading Researcher of Children and Adolescents Department

2 Yauzskaya Alleya, Moscow, 107564

Phone: +7 (499) 785-90-27

disstub@gmail.comhttps://orcid.org/0000-0001-9885-4108СтерликоваС. С.SterlikovaS. S.

Стерликова Светлана Сергеевна, врач младшего детского отделения

107564, г. Москва, ул. Яузская аллея, д. 2

Тел.: +7 (499) 785-90-27

Svetlana S. Sterlikova, Physician of Junior Children Department

2 Yauzskaya Alleya, Moscow, 107564

Phone: +7 (499) 785-90-27

detstvocniit@mail.ruhttps://orcid.org/0000-0001-9724-9862ГубкинаМ. Ф.GubkinaM. F.

Губкина Марина Федоровна, д.м.н., главный научный сотрудник детско-подросткового отдела, профессор кафедры фтизиатрии

107564, г. Москва, ул. Яузская аллея, д. 2

Тел.: +7 (499) 785-90-27

Marina F. Gubkina, Doctor of Medical Sciences,Head Researcher of Children and Adolescents Department,Professor of Phthisiology Department

2 Yauzskaya Alleya, Moscow, 107564

Phone: +7 (499) 785-90-27

gubkinamf@mail.ruhttps://orcid.org/0000-0002-5233-3515КаюковаС. И.KayukovaS. I.

Каюкова Светлана Ивановна, д.м.н., ведущий научный сотрудник, зав. лабораторией микробиома отдела иммунологии

107564, г. Москва, ул. Яузская аллея, д. 2

Тел.: +7 (499) 785-90-27

Sveltana I. Kayukova, Doctor of Medical Sciences, Leading Researcher, Head of Microbiome Laboratory, Immunology Department

2 Yauzskaya Alleya, Moscow, 107564

Phone: +7 (499) 785-90-27

detstvocniit@mail.ruФГБНУ «Центральный научно-исследовательский институт туберкулеза»РоссияCentral Tuberculosis Research InstituteRussian FederationФГБНУ «Центральный научно-исследовательский институт туберкулеза»; ФГАОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» МЗ РФРоссияCentral Tuberculosis Research Institute; Pirogov Russian National Research Medical University, Russian Ministry of HealthRussian Federation20240205202410228696Copyright © Юхименко Н.В., Стерликова С.С., Губкина М.Ф., Каюкова С.И., 20242024Юхименко Н.В., Стерликова С.С., Губкина М.Ф., Каюкова С.И.Yukhimenko N.V., Sterlikova S.S., Gubkina M.F., Kayukova S.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1808

В обзоре представлен анализ 69 источников литературы, из них 45 посвящены изучению микробиоты кишечника у больных туберкулезом. Приведены сведения о влиянии нарушения микробиоты кишечника на развитие туберкулеза, тяжесть течения и частоту рецидивов. Освещены вопросы изменения состава кишечной микробиоты при проведении противотуберкулезной терапии и влияние коррекции пробиотиками на переносимость противотуберкулезной терапии и эффективность лечения, в том числе у детей.

The review analyzes 69 publications, of which 45 are devoted to studying gut microbiota in tuberculosis patients. The review presents data on the effect of gut microbiota disorders on the development of tuberculosis, severity and relapse rate. It covers the issues of changes in gut microbiota composition during anti-tuberculosis therapy and the effect of their management with probiotics on the tolerability of anti-tuberculosis therapy and effectiveness of treatment, including children.

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The authors declare that there are no conflicts of interest present.