tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2024-102-5-91-98tiblj-1845Research ArticleОБЗОРREVIEWПредставления о популяционной генетике и филогеографии Mycobacterium tuberculosisInsights into Population Genetics and Phylogeography of Mycobacterium tuberculosisТхоренкоБ. А.TkhorenkoB. A.

Тхоренко Борис Александрович, инженер-исследователь кафедры молекулярной и клеточной биологии

650056, г. Кемерово, ул. Ворошилова, д. 22а Тел.: + 7 (3842) 52-10-18

Boris A. Tkhorenko, Engineer and Researcher of Molecular and Cellular Biology Department

22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18

tba2008@mail.ruМейерА. В.MeyerA. V.

Мейер Алина Викторовна, доцент кафедры молекулярной и клеточной биологии

650056, г. Кемерово, ул. Ворошилова, д. 22а Тел.: + 7 (3842) 52-10-18

Alina V. Meyer, Associate Professor of Molecular and Cellular Biology Department

22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18

shapo-alina@yandex.ruПьянзоваТ. В.PyanzovaT. V.

Пьянзова Татьяна Владимировна, заведующая кафедрой фтизиатрии

650056, г. Кемерово, ул. Ворошилова, д. 22а Тел.: + 7 (3842) 52-10-18

Tatiana V. Pyanzova, Head of Phthisiology Department

22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18

tatyana_vezhnina@mail.ruЛяминА. В.LyaminA. V.

Лямин Артем Викторович, директор научно-образовательного профессионального центра генетических и лабораторных технологий

443099, г. Самара, ул. Чапаевская, д. 89 Тел.: + 7 (846) 374-91-00

Artem V. Lyamin, Director of Scientific and Educational Professional Center for Genetic and Laboratory Technologies

89 Chapaevskaya St., Samara, 443099 Phone: + 7 (846) 374-91-00

a.v.lyamin@samsmu.ruЛавряшинаМ. Б.LavryashinaM. B.

Лавряшина Мария Борисовна, заведующая кафедрой молекулярной и клеточной биологии

650056, г. Кемерово, ул. Ворошилова, д. 22а Тел.: + 7 (3842) 52-10-18

Mariya B. Lavryashina, Head of Molecular and Cellular Biology Department

22A Voroshilova St., Kemerovo, 650056 Phone: + 7 (3842) 52-10-18

Lmb2001@mail.ruФГБОУ ВО «Кемеровский государственный медицинский университет» МЗ РФРоссияKemerovo State Medical University, Russian Ministry of HealthRussian FederationФГБОУ ВО «Самарский государственный медицинский университет» МЗ РФРоссияSamara State Medical University, Russian Ministry of HealthRussian Federation20241411202410259198Copyright © Тхоренко Б.А., Мейер А.В., Пьянзова Т.В., Лямин А.В., Лавряшина М.Б., 20242024Тхоренко Б.А., Мейер А.В., Пьянзова Т.В., Лямин А.В., Лавряшина М.Б.Tkhorenko B.A., Meyer A.V., Pyanzova T.V., Lyamin A.V., Lavryashina M.B.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1845

В обзоре обобщены современные представления о популяционной генетике и генетической классификации Mycobacterium tuberculosis. Источником информации послужили статьи, аккумулированные в научных библиотеках Elibrary и PubMed. По ключевым словам найдено и проанализировано более 100 публикаций за период с 2009 по 2023 гг., 35 из которых включены в материалы статьи. Согласно современным представлениям, M. tuberculosis представлена девятью линиями (суперсемейства L1-L9), каждая из которых обладает различными характеристиками эволюционного статуса, генетического разнообразия, трансмиссивности, лекарственной устойчивости, латентности и эффективности вакцины.

The review summarizes the current understanding of population genetics and genetic classification of Mycobacterium tuberculosis. Articles accumulated in Elibrary and PubMed were used as a source of information. Using keywords, more than 100 publications were found and analyzed for the period from 2009 to 2023, 35 of which were included in the review. According to the current concept, M. tuberculosis is represented by nine lineages (superfamilies L1-L9), each of which has different characteristics of evolutionary status, genetic diversity, transmissibility, drug resistance, latency, and vaccine effectiveness.

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The authors declare that there are no conflicts of interest present.