tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2024-102-6-118-126tiblj-1858Research ArticleОБЗОРREVIEWСовременный взгляд на патофизиологию кашляA Modern View of Cough PathophysiologyБудневскийА. В.BudnevskiyA. V.

Будневский Андрей Валериевич - д. м. н., профессор, заслуженный изобретатель РФ, заведующий кафедрой факультетской терапии

394036, г. Воронеж, ул. Студенческая, д. 10

Тел.: + 7 (473) 263-81-30

Andrey V. Budnevskiy - Doctor of Medical Sciences, Professor, Honored Innovator of Russia, Head of Faculty Therapy Department

10 Studencheskaya St., Voronezh 394036

Phone: + 7 (473) 263-81-30

budnev@list.ruАвдеевС. Н.AvdeevS. N.

Авдеев Сергей Николаевич - д. м. н., академик РАН, профессор, заведующий кафедрой пульмонологии Института клинической медицины им. Н.В. Склифосовского

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

Тел.: + 7 (495) 708-35-76

Sergey N. Avdeev - Doctor of Medical Sciences, Academician of RAS, Professor, Head of Pulmonology Department, Institute of Clinical Medicine named after N.V. Sklifosovsky

8 Bd. 2, Trubetskaya St., Moscow, 119991

Phone: + 7 (495) 708-35-76

serg_avdeev@list.ruОвсянниковЕ. С.OvsyannikovE. S.

Овсянников Евгений Сергеевич - д. м. н., профессор кафедры факультетской терапии

394036, г. Воронеж, ул. Студенческая, д. 10

Тел.: + 7 (473) 263-81-30

Evgeny S. Ovsyannikov - Doctor of Medical Sciences, Professor of Faculty Therapy Department

10 Studencheskaya St., Voronezh 394036

Phone: + 7 (473) 263-81-30

ovses@yandex.ruФейгельманС. Н.FeygelmanS. N.

Фейгельман Софья Николаевна - ассистент кафедры факультетской терапии

394036, г. Воронеж, ул. Студенческая, д. 10

Тел.: + 7 (473) 263-81-30

Sophya N. Feygelman - Assistant of Faculty Therapy Department

10 Studencheskaya St., Voronezh 394036

Phone: + 7 (473) 263-81-30

s.feygelman@gmail.comФГБОУ ВО «Воронежский государственный медицинский университет имени Н.Н. Бурденко» МЗ РФРоссияVoronezh State Medical Academy Named after N.N. Burdenko, Russian Ministry of HealthRussian FederationФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова МЗ РФ (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of HealthRussian Federation2024191220241026118126Copyright © Будневский А.В., Авдеев С.Н., Овсянников Е.С., Фейгельман С.Н., 20242024Будневский А.В., Авдеев С.Н., Овсянников Е.С., Фейгельман С.Н.Budnevskiy A.V., Avdeev S.N., Ovsyannikov E.S., Feygelman S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1858

Кашель обеспечивает очищение верхних дыхательных путей от инородных частиц, слизи, микроорганизмов, поэтому врачу любой специальности необходимо знать особенности физиологии данного безусловного рефлекса для лучшего понимания его природы. В обзоре представлено 43 литературных источника. Анализируются виды, частота, распространенность хронического кашля, афферентное и эфферентное звенья кашлевого рефлекса, центральная регуляция и участие медиаторов воспаления.

Cough ensures cleansing of the upper respiratory tract from foreign particles, mucus, and microorganisms, so a health care professional specializing in any field needs to know the physiology of this unconditional reflex for a better understanding of its nature. 43 publications are presented in the review. It analyzes types, frequency, prevalence of chronic cough, afferent and efferent links of the cough reflex, central regulation, and involvement of inflammatory mediators.

кашельпатофизиология кашлягиперчувствительность кашлевого рефлексахронический кашельcoughpathophysiology of coughhypersensitivity of the cough reflexchronic coughReferencesБудневский А.В., Авдеев С.Н., Овсянников Е.С., Фейгельман С.Н., Чопоров О.Н., Максимов А.В., Перцев А.В. Спектральный анализ звуков кашля у больных COVID-19 // Пульмонология. – 2022. – Т. 32, № 6. – С. 834-841. https://doi.org/10.18093/0869-0189-2022-32-6-834-841Budnevskiy A.V., Avdeev S.N., Ovsyannikov E.S., Feygelman S.N., Choporov O.N., Maksimov A.V., Pertsev A.V. Spectral analysis of cough sounds of patients with COVID-19. Pulmonologiya, 2022, vol. 32, no. 6, pp. 834-841. (In Russ.) https://doi.org/10.18093/0869-0189-2022-32-6-834-841Будневский А.В., Овсянников Е.С., Фейгельман С.Н. Исследование эффективности Левопронта в лечении непродуктивного кашля // Практическая пульмонология. – 2021. – № 2. – С. 65-74. https://doi.org/10.24412/2409-6636-2021-12693Budnevskiy A.V., Ovsyannikov E.S., Feygelman S.N. The study of the efficacy of Levopront for the treatment of non-productive cough. Prakticheskaya Pulmonologiya, 2021, no. 2, pp. 65-74. (In Russ.) https://doi.org/10.24412/2409-6636-2021-12693Булгакова В.А., Игнатова А.С. Кашель: от понимания патофизиологии к выбору терапии // Педиатрия. Журнал им. Г. Н. Сперанского. – 2017. – Т. 1, № 96. – С. 142-150.Bulgakova V.A., Ignatova A.S. Cough: from understanding the pathophysiology to the choice of therapy. Pediatriya. Journal im. G.N. Speranskogo, 2017, vol. 1, no. 96, pp. 142-150. (In Russ.)Овсянников Е.С., Авдеев С.Н., Будневский А.В., Дробышева Е.С. Диагностика кашля: настоящее и будущее // Туберкулез и болезни легких. – 2021. – Т. 99, № 11. – С. 56-65. https://doi.org/10.21292/2075-1230-2021-99-11-56-64Ovsyannikov E.S., Avdeev S.N., Budnevskiy A.V., Drobysheva E.S. Cough diagnosis: present and future. Tuberculosis and Lung Diseases, 2021, vol. 99, no. 11, pp. 56-65. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-11-56-64Овсянников Е.С., Фейгельман С.Н., Алексеева Н.Г. К вопросу о лечении кашля у больных COVID-19 // Терапия. – 2022. – Т. 8, № S4(56). – С. 99-102. https://doi.org/10.18565/therapy.2022.4suppl.100-103Ovsyannikov E.S., Feygelman S.N., Alekseeva N.G. On the issue of cough treatment in COVID-19 patients. Terapiya, 2022, vol. 8, no. S4(56), pp. 99-102. (In Russ.) https://doi.org/10.18565/therapy.2022.4suppl.100-103Abdulqawi R., Dockry R., Holt K., Layton G., McCarthy B.G., Ford A.P., Smith J.A. P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study // Lancet. – 2015. – Vol. 9974, № 385. – P. 1198-1205. https://doi.org/10.1016/S0140-6736(14)61255-1Abdulqawi R., Dockry R., Holt K., Layton G., McCarthy B.G., Ford A.P., Smith J.A. P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study. Lancet, 2015, vol. 9974, no. 385, pp. 1198-1205. https://doi.org/10.1016/S0140-6736(14)61255-1Bessac B.F., Jordt S.E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control // Physiology (Bethesda). – 2008.– № 23. – P. 360-370. https://doi.org/10.1152/physiol.00026.2008Bessac B.F., Jordt S.E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda), 2008, no. 23, pp. 360-370. https://doi.org/10.1152/physiol.00026.2008Bonvini S.J., Birrell M.A., Smith J.A., Belvisi M.G. Targeting TRP channels for chronic cough: from bench to bedside // Naunyn Schmiedebergs Arch Pharmacol. – 2015. – № 388. – P. 401-420.Bonvini S.J., Birrell M.A., Smith J.A., Belvisi M.G. Targeting TRP channels for chronic cough: from bench to bedside. Naunyn Schmiedebergs Arch. Pharmacol., 2015, no. 388, pp. 401-420.Canning B.J., Chang A.B., Bolser D.C., Smith J.A., Mazzone S.B., McGarvey L. Anatomy and neuro- physiology of cough: CHEST Guideline and EXpert Panel report // Chest. – 2014. - № 146. – P. 1633-1648. https://doi.org/10.1378/chest.14-1481Canning B.J., Chang A.B., Bolser D.C., Smith J.A., Mazzone S.B., McGarvey L. Anatomy and neuro- physiology of cough: CHEST Guideline and EXpert Panel report. Chest, 2014, no. 146, pp. 1633-1648. https://doi.org/10.1378/chest.14-1481Canning B.J. Afferent nerves regulating the cough reflex: Mechanisms and Mediators of Cough in Disease // Otolaryngol. Clin. North Am. – 2010. – Vol. 1, № 43. – P. 15-25, vii. https://doi.org/10.1016/j.otc.2009.11.012Canning B.J. Afferent nerves regulating the cough reflex: Mechanisms and Mediators of Cough in Disease. Otolaryngol. Clin. North Am., 2010, vol. 1, no. 43, pp. 15-25, vii. https://doi.org/10.1016/j.otc.2009.11.012Canning B.J. Central regulation of the cough reflex: therapeutic implications // Pulm Pharmacol Ther. – 2009. – № 22. – P. 75-81. https://doi.org/10.1016/j.pupt.2009.01.003Canning B.J. Central regulation of the cough reflex: therapeutic implications. Pulm. Pharmacol. Ther., 2009, no. 22, pp. 75-81. https://doi.org/10.1016/j.pupt.2009.01.003Choudry N.B., Fuller R.W. Sensitivity Of The Cough Reflex In patients with chronic cough // Eur Respir J. – 1992. – № 5. – P. 296-300.Choudry N.B., Fuller R.W. Sensitivity of the cough reflex in patients with chronic cough. Eur. Respir. J., 1992, no. 5, pp. 296-300.Chung K.F., Canning B., McGarvey L. Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough // Pulm Pharmacol Ther. – 2015. – № 35. – P. 76-80. https://doi.org/10.1016/j.pupt.2015.08.009Chung K.F., Canning B., McGarvey L. Eight International London Cough Symposium 2014: Cough hypersensitivity syndrome as the basis for chronic cough. Pulm. Pharmacol. Ther., 2015, no. 35, pp. 76-80. https://doi.org/10.1016/j.pupt.2015.08.009Chung K.F., Pavord I.D. Prevalence, pathogenesis, and causes of chronic cough // Lancet. – 2008. – Vol. 9621, № 371. – P. 1364-1374. https://doi.org/10.1016/S0140-6736(08)60595-4Chung K.F., Pavord I.D. Prevalence, pathogenesis, and causes of chronic cough. Lancet, 2008, vol. 9621, no. 371, pp. 1364-1374. https://doi.org/10.1016/S0140-6736(08)60595-4Chung K.F. Approach to chronic cough: the neuropathic basis for cough hypersensitivity syndrome // J Thorac Dis. – 2014. – № 6. – P. 699-707. https://doi.org/10.3978/j.issn.2072-1439.2014.08.41Chung K.F. Approach to chronic cough: the neuropathic basis for cough hypersensitivity syndrome. J. Thorac. Dis., 2014, no. 6, pp. 699-707. https://doi.org/10.3978/j.issn.2072-1439.2014.08.41Chung K.F. Cough: potential pharmacological developments // EXpert Opin Investig Drugs. – 2002. – № 11. – P. 955-963 https://doi.org/10.1517/13543784.11.7.955Chung K.F. Cough: potential pharmacological developments. EXpert. Opin. Investig. Drugs, 2002, no. 11, pp. 955-963. https://doi.org/10.1517/13543784.11.7.955Dicpinigaitis P.V., Canning B.J., Garner R., Paterson B. Effect of memantine on cough reflex sensitivity: translational studies in guinea pigs and humans // J Pharmacol Exp Ther. – 2015. – Vol. 3, № 352. – P. 448-454. https://doi.org/10.1124/jpet.114.221218Dicpinigaitis P.V., Canning B.J., Garner R., Paterson B. Effect of memantine on cough reflex sensitivity: translational studies in guinea pigs and humans. J. Pharmacol. Exp. Ther., 2015, vol. 3, no. 352, pp. 448-454. https://doi.org/10.1124/jpet.114.221218Dicpinigaitis P.V., Dobkin J.B., Rauf K., Aldrich T.K. Inhibition of capsaicin-induced cough by the gamma-aminobutyric acid agonist baclofen // J Clin Pharmacol. – 1998. – № 38. – P. 364-367. https://doi.org/10.1002/j.1552-4604.1998.tb04436.xDicpinigaitis P.V., Dobkin J.B., Rauf K., Aldrich T.K. Inhibition of capsaicin-induced cough by the gamma-aminobutyric acid agonist baclofen. J. Clin. Pharmacol., 1998, no. 38, pp. 364-367. https://doi.org/10.1002/j.1552-4604.1998.tb04436.xDicpinigaitis P.V. Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors // Ann Pharmacother. – 1996. – № 30. – P. 1242-1245. https://doi.org/10.1177/106002809603001106Dicpinigaitis P.V. Use of baclofen to suppress cough induced by angiotensin-converting enzyme inhibitors. Ann. Pharmacother., 1996, no. 30, pp. 1242-1245. https://doi.org/10.1177/106002809603001106Driessen A.K., McGovern A.E., Narula M., Yang S.K., Keller J.A., Farrell M.J., Mazzone S.B. Central mechanisms of airway sensation and cough hypersensitivity // Pulm Pharmacol Ther. – 2017. – № 47. – P. 9-15. https://doi.org/10.1016/j.pupt.2017.01.010Driessen A.K., McGovern A.E., Narula M., Yang S.K., Keller J.A., Farrell M.J., Mazzone S.B. Central mechanisms of airway sensation and cough hypersensitivity. Pulm. Pharmacol. Ther., 2017, no. 47, pp. 9-15. https://doi.org/10.1016/j.pupt.2017.01.010Ebihara S., Ebihara T., Kanezaki M., Gui P., Yamasaki M., Arai H., Kohzuki M. Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers // Cough. – 2011. – № 7. – P. 3. https://doi.org/10.1186/1745-9974-7-3Ebihara S., Ebihara T., Kanezaki M., Gui P., Yamasaki M., Arai H., Kohzuki M. Aging deteriorated perception of urge-to-cough without changing cough reflex threshold to citric acid in female never-smokers. Cough, 2011, no. 7, pp. 3. https://doi.org/10.1186/1745-9974-7-3Eccles R. Central mechanisms IV: conscious control of cough and the placebo effect // Handb EXp Pharmacol. – 2009. – № 187. – P. 241-262. https://doi.org/10.1007/978-3-540-79842-2_12Eccles R. Central mechanisms IV: conscious control of cough and the placebo effect. Handb. EXp. Pharmacol., 2009, no. 187, pp. 241-262. https://doi.org/10.1007/978-3-540-79842-2_12Escamilla R., Roche N. Cough hypersensitivity syndrome: towards a new approach to chronic cough // European Respiratory Journal. – 2014. – №44.– P. 1103-1106. https://doi.org/10.1183/09031936.00150614Escamilla R., Roche N. Cough hypersensitivity syndrome: towards a new approach to chronic cough. European Respiratory Journal, 2014, no. 44, pp. 1103-1106. https://doi.org/10.1183/09031936.00150614Gibson P., Wang G., McGarvey L., Vertigan A.E., Altman K.W., Birring S.S., CHEST Expert Cough Panel. Treatment of unexplained chronic cough: Chest guideline and expert panel report // Chest. – 2016. – № 149. – P. 27-44. https://doi.org/10.1378/chest.15-1496Gibson P., Wang G., McGarvey L., Vertigan A.E., Altman K.W., Birring S.S., CHEST Expert Cough Panel. Treatment of unexplained chronic cough: Chest guideline and expert panel report. Chest, 2016, no. 149, pp. 27-44. https://doi.org/10.1378/chest.15-1496Haque R.A., Usmani O.S., Barnes P.J. Chronic Idiopathic Cough: A Discrete Clinical Entity? // Chest. – 2005. – № 127. – P. 1710-1713. https://doi.org/10.1378/chest.127.5.1710Haque R.A., Usmani O.S., Barnes P.J. Chronic idiopathic cough: a discrete clinical entity? Chest, 2005, no. 127, pp. 1710-1713. https://doi.org/10.1378/chest.127.5.1710Hilton E., Marsden P., Thurston A., Kennedy S., Decalmer S., Smith J.A. Clinical features of the urge-to-cough in patients with chronic cough // Respiratory Medicine. – 2015. – № 109. – P. 701-707. https://doi.org/10.1016/j.rmed.2015.03.011Hilton E., Marsden P., Thurston A., Kennedy S., Decalmer S., Smith J.A. Clinical features of the urge-to-cough in patients with chronic cough. Respiratory Medicine, 2015, no. 109, pp. 701-707. https://doi.org/10.1016/j.rmed.2015.03.011Kardos P., Dinh Q.T., Fuchs K.H., Gillissen A., Klimek L., Koehler M., Sitter H., Worth H. German Respiratory Society guidelines for diagnosis and treatment of adults suffering from acute, subacute and chronic cough // Respir Med. – 2020. – № 170. – P. 105939. https://doi.org/10.1016/j.rmed.2020.105939Kardos P., Dinh Q.T., Fuchs K.H., Gillissen A., Klimek L., Koehler M., Sitter H., Worth H. German Respiratory Society guidelines for diagnosis and treatment of adults suffering from acute, subacute and chronic cough. Respir. Med., 2020, no. 170, pp. 105939. https://doi.org/10.1016/j.rmed.2020.105939Kardos P. [Chronic Idiopathic Cough] // Dtsch Med Wochenschr. – 2017. – № 142. – P. 197-200. https://doi.org/10.1055/s-0042-121765Kardos P. Chronic idiopathic cough. Dtsch. Med. Wochenschr., 2017, no. 142, pp. 197-200. https://doi.org/10.1055/s-0042-121765Kauffmann F., Varraso R. The epidemiology of cough // Pulm Pharmacol Ther. – 2011. – № 24. – P. 289-294. https://doi.org/10.1016/j.pupt.2010.10.012Kauffmann F., Varraso R. The epidemiology of cough. Pulm. Pharmacol. Ther., 2011, no. 24, pp. 289-294. https://doi.org/10.1016/j.pupt.2010.10.012Lee K.K., Birring S.S. Cough and sleep // Lung. – 2010. –№ 188 (Suppl 1). – P. 91-94. https://doi.org/10.1007/s00408-009-9176-0Lee K.K., Birring S.S. Cough and sleep. Lung, 2010, no. 188, suppl. 1, pp. 91-94. https://doi.org/10.1007/s00408-009-9176-0Lee K.K., Davenport P.W., Smith J.A., Irwin R.S., McGarvey L., Mazzone S.B., Birring S.S., CHEST Expert Cough Panel. Global Physiology and Pathophysiology of Cough: Part 1: Cough Phenomenology – CHEST Guideline and Expert Panel Report // Chest. – 2021. – Vol. 1, № 159. – P. 282-293. https://doi.org/10.1016/j.chest.2020.08.2086Lee K.K., Davenport P.W., Smith J.A., Irwin R.S., McGarvey L., Mazzone S.B., Birring S.S., CHEST Expert Cough Panel. Global Physiology and Pathophysiology of Cough. Part 1. Cough Phenomenology – CHEST Guideline and Expert Panel Report. Chest, 2021, vol. 1, no. 159, pp. 282-293. https://doi.org/10.1016/j.chest.2020.08.2086Lee S.P., Lee S.M., Lee B.J., Kang S.Y. Effectiveness and Safety of Codeine and Levodropropizine in Patients With Chronic Cough // J Korean Med Sci. – 2022. – Vol. 36, № 37. – P. e275. https://doi.org/10.3346/jkms.2022.37.e275Lee S.P., Lee S.M., Lee B.J., Kang S.Y. Effectiveness and safety of codeine and levodropropizine in patients with chronic cough. J. Korean Med. Sci., 2022, vol. 36, no. 37, pp. e275. https://doi.org/10.3346/jkms.2022.37.e275Macedo P., Zhang Q., Saito J., Liang Z., Ffolkes L., Nicholson A.G., Chung K.F. Analysis of bronchial biopsies in chronic cough // Respir Med. – 2017. – № 127. – P. 40-44. https://doi.org/10.1016/j.rmed.2017.04.001Macedo P., Zhang Q., Saito J., Liang Z., Ffolkes L., Nicholson A.G., Chung K.F. Analysis of bronchial biopsies in chronic cough. Respir. Med., 2017, no. 127, pp. 40-44. https://doi.org/10.1016/j.rmed.2017.04.001Mazzone S.B., McLennan L., McGovern A.E., Egan G.F., Farrell M.J. Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging // Am J Respir Crit Care Med. – 2007.– Vol. 4, № 176. – P. 327-332. https://doi.org/10.1164/rccm.200612-1856OCMazzone S.B., McLennan L., McGovern A.E., Egan G.F., Farrell M.J. Representation of capsaicin-evoked urge-to-cough in the human brain using functional magnetic resonance imaging. Am. J. Respir. Crit. Care Med., 2007, vol. 4, no. 176, pp. 327-332. https://doi.org/10.1164/rccm.200612-1856OCPasternak G.W., Pan Y-X. Mu Opioids and Their Receptors: Evolution of a Concept // Pharmacol. Rev. – 2013. – Vol. 4, № 65. – P. 1257-1317. https://doi.org/10.1124/pr.112.007138Pasternak G.W., Pan Y-X. Mu Opioids and their receptors: evolution of a concept. Pharmacol. Rev., 2013, vol. 4, no. 65, pp. 1257-1317. https://doi.org/10.1124/pr.112.007138Plevkova J., Kollarik M., Poliacek I., Brozmanova M., Surdenikova L., Tatar M., Mori N., Canning B.J. The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol // J Appl Physiol. – 2013. – № 115. – P. 268-274. https://doi.org/10.1152/japplphysiol.01144.2012Plevkova J., Kollarik M., Poliacek I., Brozmanova M., Surdenikova L., Tatar M., Mori N., Canning B.J. The role of trigeminal nasal TRPM8-expressing afferent neurons in the antitussive effects of menthol. J. Appl. Physiol., 2013, no. 115, pp. 268-274. https://doi.org/10.1152/japplphysiol.01144.2012Ryan N.M., Gibson P.G., Birring S.S. Arnold's nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy // J Thorac Dis. – 2014. – №6 (Suppl 7). – P. 748-752. https://doi.org/10.3978/j.issn.2072-1439.2014.04.22Ryan N.M., Gibson P.G., Birring S.S. Arnold's nerve cough reflex: evidence for chronic cough as a sensory vagal neuropathy. J. Thorac. Dis., 2014, no. 6, suppl. 7, pp. 748-752. https://doi.org/10.3978/j.issn.2072-1439.2014.04.22Smith J., Houghton L. The esophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes // Cough. – 2013. – № 9. – P. 12. https://doi.org/10.1186/1745-9974-9-12Smith J., Houghton L. The esophagus and cough: laryngo-pharyngeal reflux, microaspiration and vagal reflexes. Cough, 2013, no. 9, pp. 12. https://doi.org/10.1186/1745-9974-9-12Song W.J., Chang Y.S., Faruqi S., Kim J.Y., Kang M.G., Kim S., Jo E.J., Kim M.H., Plevkova J., Park H.W., Cho S.H., Morice A.H. The global epidemiology of chronic cough in adults: a systematic review and meta-analysis // Eur Respir J. – 2015. – № 45. – P. 1479-1481. https://doi.org/10.1183/09031936.00218714Song W.J., Chang Y.S., Faruqi S., Kim J.Y., Kang M.G., Kim S., Jo E.J., Kim M.H., Plevkova J., Park H.W., Cho S.H., Morice A.H. The global epidemiology of chronic cough in adults: a systematic review and meta-analysis. Eur. Respir. J., 2015, no. 45, pp. 1479-1481. https://doi.org/10.1183/09031936.00218714Song W.J., Morice A.H. Cough Hypersensitivity Syndrome: A Few More Steps Forward // Allergy Asthma Immunol Res. – 2017. – № 9. – P. 394 - 402. https://doi.org/10.4168/aair.2017.9.5.394Song W.J., Morice A.H. Cough hypersensitivity syndrome: a few more steps forward. Allergy Asthma Immunol. Res., 2017, no. 9, pp. 394-402. https://doi.org/10.4168/aair.2017.9.5.394Undem B.J., Carr M.J. Targeting primary afferent nerves for novel antitussive therapy // Chest. – 2010. – № 137. – P. 177-184. https://doi.org/10.1378/chest.09-1960Undem B.J., Carr M.J. Targeting primary afferent nerves for novel antitussive therapy. Chest, 2010, no. 137, pp. 177-184. https://doi.org/10.1378/chest.09-1960Vertigan A.E., Bone S.L., Gibson P.G. Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome // Respirology. – 2013. – № 18. – P. 948-956. https://doi.org/10.1111/resp.12103Vertigan A.E., Bone S.L., Gibson P.G. Laryngeal sensory dysfunction in laryngeal hypersensitivity syndrome. Respirology, 2013, no. 18, pp. 948-956. https://doi.org/10.1111/resp.12103Widdicombe J. Functional morphology and physiology of pulmonary rapidly adapting receptors (RARs) // Anat Rec A Discov Mol Cell Evol Biol. – 2003. – № 270. – P. 2-10. https://doi.org/10.1002/ar.a.10003Widdicombe J. Functional morphology and physiology of pulmonary rapidly adapting receptors (RARs). Anat. Rec. A Discov. Mol. Cell Evol. Biol., 2003, no. 270, pp. 2-10. https://doi.org/10.1002/ar.a.10003

The authors declare that there are no conflicts of interest present.