tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2025-103-2-93-101tiblj-1886Research ArticleОБЗОРREVIEWСтадии туберкулезной инфекции, что нового? (обзор литературы)Stages of Tuberculosis Infection, What's New? (Literature Review)https://orcid.org/0000-0001-9956-2385СлогоцкаяЛ. В.SlogotskayaL. V.

Слогоцкая Людмила Владимировна - Д. м. н., заведующая научно-клиническим отделом

107014, Москва, ул. Стромынка, д. 10

Тел.: + 7 (499) 268-00-05

Ludmila V. Slogotskaya - Doctor of Medical Sciences, Head of Research Clinical Department

10 Stromynka St., Moscow, 107014

Phone: + 7 (499) 268-00-05

lyu186@yandex.ruhttps://orcid.org/0000-0002-3091-4677ЛовачеваО. В.LovachevaO. V.

Ловачева Ольга Викторовна - Д. м. н., профессор, главный научный сотрудник научного отдела дифференциальной диагностики и лечения туберкулеза и сочетанных инфекций

127473, Москва, ул. Достоевского, д. 4, к. 2

Тел.+7 (495) 631-15-15

Olga V. Lovacheva - Doctor of Medical Sciences, Professor, Chief Researcher of Researcher Department of Differential Diagnosis and Treatment of Tuberculosis and Concurrent Infections

Build. 2, 4 Dostoevskiy St., Moscow, 127473

Тел.+7 (495) 631-15-15

olga.lovacheva@yandex.ruhttps://orcid.org/0000-0003-0973-3289КлевноН. И.KlevnoN. I.

Клевно Надежда Ивановна - Д. м. н., профессор, главный научный сотрудник детско-подросткового отдела

127473, Москва, ул. Достоевского, д. 4, к. 2

Тел.+7 (495) 631-15-15

Nadezhda I. Klevno - Doctor of Medical Sciences, Professor, Head Researcher of Children and Adolescents Department

Build. 2, 4 Dostoevskiy St., Moscow, 127473

Тел.+7 (495) 631-15-15

n.i.klevno@mail.ruГБУЗ «Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения города Москвы»РоссияMoscow Research and Clinical Center for Tuberculosis Control of the Moscow Government Department of HealthRussian FederationФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФРоссияNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthRussian Federation202527042025103293101Copyright © Слогоцкая Л.В., Ловачева О.В., Клевно Н.И., 20252025Слогоцкая Л.В., Ловачева О.В., Клевно Н.И.Slogotskaya L.V., Lovacheva O.V., Klevno N.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1886

В обзоре, основываясь на 43 источниках литературы, представлены современные сведения о вариантах развития туберкулезной инфекции у человека и доклинических проявлениях туберкулеза. Описаны направления научных исследований для создания тестов, позволяющих определить различные состояния взаимодействия организма человека и МБТ. Наиболее эпидемически важны тесты, выявляющие состояния крайне приближенные к туберкулезу и прогнозирующие его начало в короткое время, что позволило бы более эффективно и адресно проводить превентивную химиотерапию.

The review is based on 43 publications and it presents current information on variants of tuberculosis infection development in humans and preclinical manifestations of tuberculosis. It describes research trends aimed to develop tests to detect various states of interaction between the host and M. tuberculosis. The most epidemically important tests are those that can detect conditions very similar to tuberculosis and predict onset of tuberculosis in a short time allowing more effective and targeted preventive chemotherapy.

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The authors declare that there are no conflicts of interest present.