tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2025-103-2-102-110tiblj-1887Research ArticleОБЗОРREVIEWПути совершенствования диагностических подходов при саркоидозе легких (обзор литературы)Ways to Enhance the Diagnosis of Pulmonary Sarcoidosis (Literature Review)https://orcid.org/0000-0002-6273-4304ЗинченкоЮ. С.ZinchenkoYu. S.

Зинченко Юлия Сергеевна - К. м. н., старший научный сотрудник, руководитель НИЛ изучения неспецифических заболеваний легких

191036, г. Санкт-Петербург, Лиговский пр., д. 2-4

Тел.: +7 (812) 775-75-50

Yulia S. Zinchenko - Candidate of Medical Sciences, Senior Researcher, Head of Research Laboratory of Non-Specific Lung Diseases

2-4 Ligovsky Ave., St. Petersburg, 191036

Phone: +7 (812) 775-75-50

ulia-zinchenko@yandex.ruhttps://orcid.org/0000-0001-8682-9909ПоляковаВ. О.PolyakovaV. O.

Полякова Виктория Олеговна - Д. б. н., профессор, заместитель директора

191036, г. Санкт-Петербург, Лиговский пр., д. 2-4

Тел.: +7 (812) 775-75-50

Viktoria O. Polyakova - Doctor of Biological Sciences, Professor, Deputy Director

2-4 Ligovsky Ave., St. Petersburg, 191036

Phone: +7 (812) 775-75-50

vo.polyakova@spbniif.ruhttps://orcid.org/0000-0002-6974-5305МуравьевА. Н.MuravievA. N.

Муравьев Александр Николаевич - К. м. н., ведущий научный сотрудник, руководитель НИЛ клеточной биологии и регенеративной медицины, ученый секретарь

191036, г. Санкт-Петербург, Лиговский пр., д. 2-4

Тел.: +7 (812) 775-75-50

Aleksandr N. Muraviev - Candidate of Medical Sciences, Leading Researcher, Head of Research Laboratory of Cellular Biology and Regenerative Medicine, Academic Secretary

2-4 Ligovsky Ave., St. Petersburg, 191036

Phone: +7 (812) 775-75-50

urolog5@gmail.comТубееваИ. Р.TubeevaI. R.

Тубеева Илона Робертовна - Клинический ординатор

191036, г. Санкт-Петербург, Лиговский пр., д. 2-4

Тел.: +7 (812) 775-75-50

Ilona R. Tubeeva - Resident Physician

2-4 Ligovsky Ave., St. Petersburg, 191036

Phone: +7 (812) 775-75-50

ilona_tubeeva@mail.ruhttps://orcid.org/0000-0002-5778-2213СтаревскаяС. В.StarevskayaS. V.

Старевская Светлана Валерьевна - Д. м. н., ведущий научный сотрудник, руководитель направления детской пульмонологии, доцент кафедры педиатрии и детской кардиологии ФГБОУ ВПО «Северо-Западный государственный медицинский университет им. И.И. Мечникова»

191036, г. Санкт-Петербург, Лиговский пр., д. 2-4

Тел.: +7 (812) 775-75-50

Svetlana V. Starevskaya Doctor of Medical Sciences, Leading Researcher, Head of Pediatric Pulmonology Unit, Associate Professor of Pediatrics and Pediatric Cardiology Department, North-Western State Medical University named after I.I.Mechnikov

2-4 Ligovsky Ave., St. Petersburg, 191036

Phone: +7 (812) 775-75-50

svetlanastarevskaya@yandex.ruhttps://orcid.org/0000-0003-4385-9643ЯблонскийП. К.YablonskiyP. K.

Яблонский Петр Казимирович - Д. м. н., профессор, директор, заведующий кафедрой госпитальной хирургии медицинского факультета Санкт-Петербургского государственного университета

191036, г. Санкт-Петербург, Лиговский пр., д. 2-4

Тел.: +7 (812) 775-75-50

Petr K. Yablonskiy - Doctor of Medical Sciences, Professor, Director, Head of Hospital Surgery Department of Medical Faculty of St. Petersburg University

2-4 Ligovsky Ave., St. Petersburg, 191036

Phone: +7 (812) 775-75-50

piotr_yablonskii@mail.ruФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФРоссияSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of HealthRussian FederationФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ; ФГБОУ ВПО «Северо-Западный государственный медицинский университет имени И. И. Мечникова»РоссияSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health; North-Western State Medical University Named after I.I. MechnikovRussian FederationФГБУ «Санкт-Петербургский научно-исследовательский институт фтизиопульмонологии» МЗ РФ; ФГБОУ ВО «Санкт-Петербургский государственный университет»РоссияSt. Petersburg Research Institute of Phthisiopulmonology, Russian Ministry of Health; St. Petersburg UniversityRussian Federation2025270420251032102110Copyright © Зинченко Ю.С., Полякова В.О., Муравьев А.Н., Тубеева И.Р., Старевская С.В., Яблонский П.К., 20252025Зинченко Ю.С., Полякова В.О., Муравьев А.Н., Тубеева И.Р., Старевская С.В., Яблонский П.К.Zinchenko Y.S., Polyakova V.O., Muraviev A.N., Tubeeva I.R., Starevskaya S.V., Yablonskiy P.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1887

Проведен анализ 50 публикаций по диагностическим подходам к выявлению саркоидоза. Отмечено, что этот процесс в настоящее время не стандартизирован и сопряжен с высокой вероятностью ошибок. Улучшение подходов затрагивает все аспекты диагностики – от выделения высокоспецифичных клинико-рентгенологических проявлений заболевания до выбора метода биопсии легкого. Наиболее перспективным является применение биомаркеров саркоидоза, таких, как ангиотензинпревращающий фермент, хитотриозидаза, сывороточный амилоид А. Изучается возможность их комбинации, связь с клиническими признаками заболевания, проводятся полногеномные исследования для открытия новых биомаркеров.

The article analyzes 50 publications devoted to diagnostic approaches to detection of sarcoidosis. It highlights that currently diagnosis of this disease is not standardized and thus errors are highly possible to occur. Improved approaches address all aspects of diagnosis, from the distinction of highly specific clinical and radiologic signs of the disease to the choice of lung biopsy method. The use of sarcoidosis biomarkers such as angiotensin-converting enzyme, chitotriosidase, and serum amyloid A is most promising. The possibility of their combination and association with clinical signs of the disease are being studied, and to discover new biomarkers, full-genome studies are being in progress.

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The authors declare that there are no conflicts of interest present.