tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2025-103-4-100-108tiblj-1913Research ArticleОБЗОРЫREVIEWSФлавоноиды в качестве перспективных препаратов сопровождения при длительной терапии туберкулеза с лекарственной устойчивостьюFlavonoids as Promising Drugs for Concomitant Therapy during Long-Term Therapy of Drug-Resistant TuberculosisМасляковаГ. Н.MaslyakovaG. N.

Маслякова Галина Никифоровна, д. м. н., профессор, заведующая кафедрой патологической анатомии

410012, Саратов, ул. Большая Казачья, 112 Тел.: +7 (8452) 49-33-03

Galina N. Maslyakova, Doctor of Medical Sciences, Professor, Head of Pathological Anatomy Department

112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03

gmaslyakova@yandex.ruПолуконоваН. В.PolukonovaN. V.

Полуконова Наталья Владимировна, д. б. н., профессор, профессор кафедры общей биологии, фармакогнозии и ботаники

410012, Саратов, ул. Большая Казачья, 112 Тел.: +7 (8452) 49-33-03

Natalya V. Polukonova, Doctor of Biological Sciences, Professor, Professor of Department of General Biology, Pharmacognosy and Botany

112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03

polukonovanv@yandex.ruМорозоваТ. И.MorozovaT. I.

Морозова Татьяна Ивановна, д. м. н., профессор, заведующая кафедрой фтизиатрии

410012, Саратов, ул. Большая Казачья, 112 Тел.: +7 (8452) 49-33-03

Tatyana I. Morozova, Doctor of Medical Sciences, Professor, Head of Phthisiology Department

112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03

ti-morozova@yandex.ruКудлайД. А.KudlayD. A.

Кудлай Дмитрий Анатольевич, член-корреспондент РАН, д. м. н., профессор кафедры фармакологии Института фармации, ведущий научный сотрудник лаборатории персонализированной медицины и молекулярной иммунологии № 71 ФГБУ «ГНЦ Институт иммунологии» ФМБА России, профессор кафедры фармакогнозии и промышленной фармации факультета фундаментальной медицины ФГБОУ ВО МГУ имени М.В. Ломоносова

119991, г. Москва, ул. Трубецкая, д. 8, стр. 2 Тел.: +7 (499) 248-05-53

Dmitry A. Kudlay, Correspondent Member of RAS, Doctor of Medical Sciences, Professor of Pharmacology Department of Pharmacy Institute, Leading Researcher of Laboratory of Personalized Medicine and Molecular Immunology no. 71, Immunology Research Institute by the Russian Federal Medical Biological Agency, Professor of Department of Pharmacognosy and Industrial Pharmacy, Faculty of Fundamental Medicine, Lomonosov

8 Bd. 2, Trubetskaya St., Moscow, 119991 Phone: +7 (499) 248-05-53

D624254@gmail.comБучарскаяА. Б.BucharskayaA. B.

Бучарская Алла Борисовна, д. б. н., руководитель Центра коллектиивного пользования экспериментальной онкологии

410012, Саратов, ул. Большая Казачья, 112 Тел.: +7 (8452) 49-33-03

Alla B. Bucharskaya, Doctor of Biological Sciences, Head of the Center for Collective Use of Experimental Oncology

112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03

allaalla_72@mail.ruПолуконоваА. В.PolukonovaA. V.

Полуконова Анна Владимировна, младший научный сотрудник лаборатории клеточных технологий Центра коллективного пользования экспериментальной онкологии

410012, Саратов, ул. Большая Казачья, 112 Тел.: +7 (8452) 49-33-03

Anna V. Polukonova, Junior Researcher of Cellular Technologies Laboratory, Center for Collective Use of Experimental Oncology

112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03

polukonova@yandex.ruНаволокинН. А.NavolokinN. A.

Наволокин Никита Александрович, к. м. н., доцент кафедры патологической анатомии

410012, Саратов, ул. Большая Казачья, 112 Тел.: +7 (8452) 49-33-03

Nikita A. Navolokin, Candidate of Medical Sciences, Associate Professor of Pathologic Anatomy Department

112 Bolshaya Kazachya St., Saratov, 410012 Phone: +7 (8452) 49-33-03

nik-navolorin@yandex.ruФГБОУ ВО «Саратовский государственный медицинский университет имени В.И. Разумовского» МЗ РФРоссияV.I. Razumovsky Saratov State Medical University, Russian Ministry of HealthRussian FederationФГАУО ВО «Первый Московский государственный медицинский университет имени И.М. Сеченова» Министерства здравоохранения Российской Федерации (Сеченовский Университет); ФГБОУ ВПО «Московский государственный университет имени М.В. Ломоносова»; ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииРоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health; Lomonosov Moscow State University; Immunology Research Institute by the Russian Federal Medical Biological AgencyRussian Federation2025120920251034100108Copyright © Маслякова Г.Н., Полуконова Н.В., Морозова Т.И., Кудлай Д.А., Бучарская А.Б., Полуконова А.В., Наволокин Н.А., 20252025Маслякова Г.Н., Полуконова Н.В., Морозова Т.И., Кудлай Д.А., Бучарская А.Б., Полуконова А.В., Наволокин Н.А.Maslyakova G.N., Polukonova N.V., Morozova T.I., Kudlay D.A., Bucharskaya A.B., Polukonova A.V., Navolokin N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1913

В обзоре проведен анализ 56 источников литературы для анализа возможности применения флавоноидов при сопровождении длительной терапии туберкулеза с множественной лекарственной устойчивостью (МЛУ ТБ) и определения актуальности таких исследований. Отбор публикаций проведен в основных базах данных, включая РИНЦ, PubMed и Google Scholar. Использование биофлавоноидов при химиотерапии туберкулеза может улучшить ее эффективность и предупреждать токсические эффекты противотуберкулезных препаратов. Актуальность исследования вызвана ростом МЛУ ТБ среди впервые выявленных пациентов.

The review analyzed 56 publications in order to investigate the possibility of using flavonoids as concomitant therapy in the long-term treatment of multidrug-resistant tuberculosis (MDR TB) and to determine the relevance of such studies. Publications were selected from main databases including RSCI, PubMed, and Google Scholar. The use of bioflavonoids in tuberculosis chemotherapy can enhance its effectiveness and prevent toxic effects of anti-tuberculosis drugs. The growing rate of MDR TB among new tuberculosis cases confirms the relevance in this study.

туберкулезмикобактериимножественная лекарственная устойчивостьфлавоноидыtuberculosismycobacteriamultiple drug resistanceflavonoidsИсследование выполнено в рамках государственного задания Министерства здравоохранения Российской Федерации (рег. № 1024030100147-3).The study was carried out as a part of the State Assignment of the Russian Ministry of Health (Reg. No. 1024030100147-3).ReferencesКурдюков Е.Е., Плешакова Д.А., Глебова Н.Н., Неклюдова В.А., Водопьянова О.А., Гаранина Е.О. Флавоноиды: классификация, биологические свойства и перспективы использования в медицине // Международный научно-исследовательский журнал. – 2023. – Т. 137, № 11. – С. 1-6. https://doi.org/10.23670/IRJ.2023.137.143Kurdyukov E.E., Pleshakova D.A., Glebova N.N., Neklyudova V.A., Vodopyanova O.A., Garanina E.O. Flavonoids: classification, biological properties and prospects of use in medicine. International Research Journal, 2023, vol. 137, no. 11, pp. 1-6. (In Russ.) https://doi.org/10.23670/IRJ.2023.137.143Куркина А.В. Актуальные вопросы химической стандартизации лекарственных растений, содержащих флавоноиды // Фармация. – 2012. – № 7. – С. 44-48.Kurkina A.V. Topical issues of chemical standardization of medicinal plants containing flavonoids. Farmatsiya, 2012, no. 7, pp. 44-48. (In Russ.)Курчатова М.Н., Дурнова Н.А., Полуконова Н.В. Влияние экстрактов, содержащих биофлавоноиды, на индукцию микроядер диоксидином в эритроцитах крови беспородных белых мышей // Вестник Воронежского государственного университета. Серия: Химия. Биология. Фармация. – 2014. – № 2. – С. 58-65.Kurchatova M.N., Durnova N.A., Polukonova N.V. The effect of extracts containing bioflavonoids on the induction of micronuclei by dioxidine in erythrocytes of blood of outbred white mice. Vestnik Voronezhskogo Gosudarstvennogo Universiteta. Seriya: Khimiya, Biologiya, Farmatsiya, 2014, no. 2, pp. 58-65. (In Russ.)Наволокин Н.А., Ивличев А.В., Мудрак Д.А., Афанасьева Г.А., Полуконова Н.В., Тычина С.А., Бучарская А.Б., Маслякова Г.Н. Влияние флавоноидсодержащего экстракта аврана лекарственного (Gratiola officinalis L.) на интенсивность процессов перекисного окисления и содержание витамина E у крыс с перевитым раком печени PC-1 // Экспериментальная и клиническая фармакология. – 2017. – Т. 80, № 10. – С. 40-43. https://doi.org/10.30906/0869-2092-2017-80-6-19-23Navolokin N.A., Ivlichev A.V., Mudrak D.A., Afanasyeva G.A., Polukonova N.V., Tychina S.A., Bucharskaya A.B., Maslyakova G.N. Influence of flavonoid-containing extract (Gratiola officinalis L.) on the level of Vitamin E and intensity of peroxidation processes in the blood of rats with transplanted liver cancer PC-1. Eksperimentalnaya i Klinicheskaya Farmakologiya, 2017, vol. 80, no. 10, pp. 40-43. (In Russ.) https://doi.org/10.30906/0869-2092-2017-80-6-19-23Наволокин Н.А., Мудрак Д.А., Матвеева О.В., Тычина С.А., Бучарская А.Б., Полуконова Н.В., Маслякова Г.Н. Влияние растительных экстрактов, содержащих флавоноиды, на лейкоцитарную формулу и красный костный мозг лабораторных крыс с перевитой саркомой 45 // Успехи современного естествознания. – 2015. – № 4. – С. 134-140.Navolokin N.A., Mudrak D.A., Matveeva O.V., Tychina S.A., Bucharskaya A.B., Polukonova N.V., Maslyakova G.N. Influence of plant extract containing flavonoids on the leucocyte formula and bone marrow of laboratory rats with transplanted sarcoma 45. Advances in Current Natural Sciences, 2015, no. 4, pp. 134-140. (In Russ.)Наволокин Н.А., Мудрак Д.А., Полуконова Н.В., Тычина С.А., Байтман Т.П., Корчаков Н.В., Воронков М.О., Бучарская А.Б., Маслякова Г.Н. Сравнение противоопухолевой и антикахексической активности флавоноидсодержащих экстрактов в эксперименте на животных с перевитой саркомой 45 // Российский биотерапевтический журнал. – 2016. – Т. 15, № 1. – С. 72-73.Navolokin N.A., Mudrak D.A., Polukonova N.V., Tychina S.A., Baytman T.P., Korchakov N.V., Voronkov M.O., Bucharskaya A.B., Maslyakova G.N. Comparison of antitumor and anti-cachexic activity of flavonoid-containing extracts in an experiment on animals with transplanted sarcoma 45. Russian Journal of Biotherapy, 2016, vol. 15, no. 1, pp. 72-73. (In Russ.)Наволокин Н.А., Скворцова В.В., Полуконова Н.В., Манаенкова Е.В., Панкратова Л.Э., Курчатова М.Н., Маслякова Г.Н., Дурнова Н.А. Противотуберкулезная активность экстракта аврана лекарственного (Gratiola officinalis L.) in vitro // Экспериментальная и клиническая фармакология. – 2015. – Т. 78, № 4. – С. 10-13.Navolokin N.A., Skvortsova V.V., Polukonova N.V., Manaenkova E.V., Pankratova L.E., Kurchatova M.N., Maslyakova G.N., Durnova N.A. Anti-tuberculosis activity of Gratiola officinalis L. extract in vitro. Eksperimentalnaya i Klinicheskaya Farmakologiya, 2015, vol. 78, no. 4, pp. 10-13. (In Russ.)Полуконова Н.В., Дурнова Н.А., Курчатова М.Н., Наволокин Н.А., Голиков А.Г. Химический анализ и способ получения новой биологически активной композиции из травы аврана лекарственного (Gratiola officinalis L.) // Химия растительного сырья. – 2013. – № 4. – С. 165-173.Polukonova N.V., Durnova N.A., Kurchatova M.N., Navolokin N.A., Golikov A.G. Chemical analysis and method for obtaining a new biologically active composition from Gratiola officinalis L. Khimiya Rastitelnogo Syrya, 2013, no. 4, pp. 165-173. (In Russ.)Полуконова Н.В., Наволокин Н.А., Дурнова Н.А., Маслякова Г.Н., Бучарская А.Б. Способ получения сухого экстракта из растительного сырья, обладающего биологической активностью: пат. 2482863 Рос. Федерация. № 2012105384/15; заявл. 15.02.2012; опубл. 27.05.2013.Polukonova N.V., Navolokin N.A., Durnova N.A., Maslyakova G.N., Bucharskaya A.B. Sposob polucheniya sukhogo ekstrakta iz rastitelnogo syrya, obladayushchego biologicheskoy aktivnostyu. [A method for obtaining a dry extract from plant raw materials that has biological activity]. Patent 2482863 of the Russian Federation. No. 2012105384/15, claimed on 15.02.2012, published 27.05.2013.Полуконова Н.В., Наволокин Н.А., Райкова С.В., Маслякова Г.Н., Бучарская А.Б., Дурнова Н.А., Шуб Г.М. Противовоспалительная, жаропонижающая и антимикробная активность флаваноидсодержащего экстракта аврана лекарственного (Gratiola officinalis L.) // Экспериментальная и клиническая фармакология. – 2015. – Т. 78, № 1. – С. 34-38.Polukonova N.V., Navolokin N.A., Raykova S.V., Maslyakova G.N., Bucharskaya A.B., Durnova N.A., Shub G.M. Anti-inflammatory, antipyretic and antimicrobial activity of flavonoid-containing extract of Gratiola officinalis L. Eksperimentalnaya i Klinicheskaya Farmakologiya, 2015, vol. 78, no. 1, pp. 34-38. (In Russ.)Полуконова Н.В., Наволокин Н.А., Райкова С.В., Юртаева А.В., Дурнова Н.А., Маслякова Г.Н., Бучарская А.Б., Шуб Г.М. Средство, обладающее противовоспалительным, жаропонижающим и антимикробным действием: пат. 2535155 Рос. Федерация. № 2013123246/15; заявл. 21.05.2013; опубл. 10.12.2014.Polukonova N.V., Navolokin N.A., Raykova S.V., Yurtaeva A.V., Durnova N.A., Maslyakova G.N., Bucharskaya A.B., Shub G.M. Sredstvo, obladayushcheye protivovospalitelnym, zharoponizhayushchim i antimikrobnym deystviyem. [A product with anti-inflammatory, antipyretic and antimicrobial effects]. Patent 2535155 of the Russian Federation. No. 2013123246/15, claimed on 21.05.2013, published 10.12.2014.Полуконова Н.В., Наволокин Н.А., Скворцова В.В., Манаенкова Е.В., Панкратова Л.Э., Маслякова Г.Н., Дурнова Н.А. Средство, обладающее противотуберкулезным действием: пат. 2549477 Рос. Федерация. № 2014108658/15; заявл. 05.03.2014; опубл. 27.04.2015.Polukonova N.V., Navolokin N.A., Skvortsova V.V., Manaenkova E.V., Pankratova L.E., Maslyakova G.N., Durnova N.A. Sredstvo, obladayushcheye protivotuberkuleznym deystviyem. [A product with anti-tuberculosis action]. Patent 2549477 of the Russian Federation. No. 2014108658/15, claimed on 05.03.2014, published 27.04.2015.Стерликов С.А., Нечаева О.Б., Галкин В.Б., Сон И.М., Тестов В.В., Попов С.А. и др. Отраслевые и экономические показатели противотуберкулезной работы в 2018-2019 гг.: Аналитический обзор основных показателей и статистические материалы / Под ред. Стерликова С.А. – Москва: РИО ЦНИИОИЗ, 2020.Sterlikov S.A., Nechaeva O.B., Galkin V.B., Son I.M., Testov V.V., Popov S.A. et al. Otraslevye i ekonomicheskie pokazateli protivotuberkuleznoy raboty v 2018-2019 gg. Analiticheskiy: obzor osnovnykh pokazateley i statisticheskiye materialy. [Sectoral and economic rates for TB control in 2018-2019. Analysis of main rates and statistic materials]. Sterlikov S.A., eds., Moscow, RIO TSNIIOIZ Publ., 2020.Шульгина М.В. Механизмы резистентности к антибактериальным препаратам у Mycobacterium tuberculosis // Молекулярная генетика, микробиология и вирусология. – 2024. – Т. 42, № 1. – С. 3-15. https://doi.org/10.17116/molgen2024420113Shulgina M.V. Mycobacterium tuberculosis drugs resistance mechanisms. Molecular Genetics, Microbiology and Virology, 2024, vol. 42, no. 1, pp. 3-15. (In Russ.) https://doi.org/10.17116/molgen2024420113Aşkun T. Investigation of anti-mycobacterial activity of orientin and vitexin on the six Mycobacterium tuberculosis strains // European Journal of Biology. – 2023. – Vol. 82, № 2. – Р. 124–131. https://doi.org/10.26650/EurJBiol.2023.1250807Aşkun T. Investigation of anti-mycobacterial activity of orientin and vitexin on the six Mycobacterium tuberculosis strains // European Journal of Biology. – 2023. – Vol. 82, № 2. – Р. 124–131. https://doi.org/10.26650/EurJBiol.2023.1250807Aydin E., Gunduz M.K., Kaymak G., Sezgin A.K., Dağgez H., Renders D.P., Yakupoğullari Y. Antimycobacterial activity of luteolin in resistant Mycobacterium tuberculosis isolates and cytotoxicity on L929 cells // Microbial Pathogenesis. – 2025. – № 200. – Р. 107287. https://doi.org/10.1016/j.micpath.2025.107287Aydin E., Gunduz M.K., Kaymak G., Sezgin A.K., Dağgez H., Renders D.P., Yakupoğullari Y. Antimycobacterial activity of luteolin in resistant Mycobacterium tuberculosis isolates and cytotoxicity on L929 cells // Microbial Pathogenesis. – 2025. – № 200. – Р. 107287. https://doi.org/10.1016/j.micpath.2025.107287Begum S., Wahab A., Siddiqui B.S. Antimycobacterial Activity of Flavonoids from Lantana camara Linn. // Natural Product Research. – 2008. – Vol. 22, № 5. – Р. 467-470. https://doi.org/10.1080/14786410600898714Begum S., Wahab A., Siddiqui B.S. Antimycobacterial Activity of Flavonoids from Lantana camara Linn. // Natural Product Research. – 2008. – Vol. 22, № 5. – Р. 467-470. https://doi.org/10.1080/14786410600898714Boniface P.K., Ferreira E.I. Opportunities and Challenges for Flavonoids as Potential Leads for the Treatment of Tuberculosis // Studies in Natural Products Chemistry. – 2020. – № 65. – Р. 85-124. https://doi.org/10.1016/B978-0-12-817905-5.00003-5Boniface P.K., Ferreira E.I. Opportunities and Challenges for Flavonoids as Potential Leads for the Treatment of Tuberculosis // Studies in Natural Products Chemistry. – 2020. – № 65. – Р. 85-124. https://doi.org/10.1016/B978-0-12-817905-5.00003-5Boonphong S., Baramee A., Kittakoop P., Puangsombat P. Antitubercular and Antiplasmodial Prenylated Flavones from the Roots of Artocarpus Altilis // Chiang Mai Journal of Science. – 2007. – Vol. 34, № 3. – Р. 339-344.Boonphong S., Baramee A., Kittakoop P., Puangsombat P. Antitubercular and Antiplasmodial Prenylated Flavones from the Roots of Artocarpus Altilis // Chiang Mai Journal of Science. – 2007. – Vol. 34, № 3. – Р. 339-344.Chokchaisiri R., Suaisom C., Sriphota S., Chindaduang A., Chuprajob T., Suksamrarn A. Bioactive Flavonoids of the Flowers of Butea monosperma // Chemical and Pharmaceutical Bulletin. – 2009. – Vol. 57, № 4. – Р. 428-432. https://doi.org/10.1248/cpb.57.428Chokchaisiri R., Suaisom C., Sriphota S., Chindaduang A., Chuprajob T., Suksamrarn A. Bioactive Flavonoids of the Flowers of Butea monosperma // Chemical and Pharmaceutical Bulletin. – 2009. – Vol. 57, № 4. – Р. 428-432. https://doi.org/10.1248/cpb.57.428Dai J., Mumper R.J. Plant phenolics: extraction, analysis and their antioxidant and anticancer properties // Molecules. – 2010. – Vol. 15, № 10. – Р. 7313-7352. https://doi.org/10.3390/molecules15107313Dai J., Mumper R.J. Plant phenolics: extraction, analysis and their antioxidant and anticancer properties // Molecules. – 2010. – Vol. 15, № 10. – Р. 7313-7352. https://doi.org/10.3390/molecules15107313Dookie N., Rambaran S., Padayatchi N., Mahomed S., Naidoo K. Evolution of Drug Resistance In Mycobacterium tuberculosis: A Review on the Molecular Determinants of Resistance and Implications for Personalized Care // Journal of Antimicrobial Chemotherapy. – 2018. – Vol. 73, № 5. – Р. 1138-1151. https://doi.org/10.1093/jac/dkx506Dookie N., Rambaran S., Padayatchi N., Mahomed S., Naidoo K. Evolution of Drug Resistance In Mycobacterium tuberculosis: A Review on the Molecular Determinants of Resistance and Implications for Personalized Care // Journal of Antimicrobial Chemotherapy. – 2018. – Vol. 73, № 5. – Р. 1138-1151. https://doi.org/10.1093/jac/dkx506Favela-Hernández J.M.J., García A., Garza-González E., Rivas-Galindo V.M., Camacho-Corona M.R. Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata // Phytotherapy Research. – 2012. – Vol. 26, № 12. – Р. 1957-1960. https://doi.org/10.1002/ptr.4660Favela-Hernández J.M.J., García A., Garza-González E., Rivas-Galindo V.M., Camacho-Corona M.R. Antibacterial and Antimycobacterial Lignans and Flavonoids from Larrea tridentata // Phytotherapy Research. – 2012. – Vol. 26, № 12. – Р. 1957-1960. https://doi.org/10.1002/ptr.4660Fedrizzi T., Meehan C.J., Grottola A., Giacobazzi E., Serpini G.F., Tagliazucchi S., Fabio A., Bettua C., Bertorelli R., De Sanctis V., et al. Genomic characterization of Nontuberculous Mycobacteria // Scientific Reports. – 2017. – № 7. – Р. 45258. https://doi.org/10.1038/srep45258Fedrizzi T., Meehan C.J., Grottola A., Giacobazzi E., Serpini G.F., Tagliazucchi S., Fabio A., Bettua C., Bertorelli R., De Sanctis V., et al. Genomic characterization of Nontuberculous Mycobacteria // Scientific Reports. – 2017. – № 7. – Р. 45258. https://doi.org/10.1038/srep45258Grinev V.S., Shirokov A.A., Navolokin N.A., Polukonova N.V., Kurchatova M.N., Durnova N.A., Bucharskaya A.B., Maslyakova G.N. Polyphenolic compounds of a new biologically active extract from immortelle sandy flowers (Helichrysum arenarium (L.) Moench.) // Russian Journal of Bioorganic Chemistry. – 2016. – Vol. 42, № 7. – Р. 770-776. https://doi.org/10.1134/S1068162016070057Grinev V.S., Shirokov A.A., Navolokin N.A., Polukonova N.V., Kurchatova M.N., Durnova N.A., Bucharskaya A.B., Maslyakova G.N. Polyphenolic compounds of a new biologically active extract from immortelle sandy flowers (Helichrysum arenarium (L.) Moench.) // Russian Journal of Bioorganic Chemistry. – 2016. – Vol. 42, № 7. – Р. 770-776. https://doi.org/10.1134/S1068162016070057Gygli S.M., Borrell S., Trauner A., Gagneux S. Antimicrobial resistance in Mycobacterium tuberculosis: Mechanistic and evolutionary perspectives // FEMS Microbiology Reviews. – 2017. – Vol. 41, № 3. – Р. 354-373. https://doi.org/10.1093/femsre/fux011Gygli S.M., Borrell S., Trauner A., Gagneux S. Antimicrobial resistance in Mycobacterium tuberculosis: Mechanistic and evolutionary perspectives // FEMS Microbiology Reviews. – 2017. – Vol. 41, № 3. – Р. 354-373. https://doi.org/10.1093/femsre/fux011Jesus R.S., Piana M., Freitas R.B., Brum T.F., Alves C.F., Belke B.V., Bauermann L.D.F. In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides L. // Brazilian Journal of Microbiology. – 2018. – Vol. 49, № 2. – Р. 296–302. https://doi.org/10.1016/j.bjm.2017.08.002Jesus R.S., Piana M., Freitas R.B., Brum T.F., Alves C.F., Belke B.V., Bauermann L.D.F. In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides L. // Brazilian Journal of Microbiology. – 2018. – Vol. 49, № 2. – Р. 296–302. https://doi.org/10.1016/j.bjm.2017.08.002Khan M., Khan S., Alshammary F., Zaidi S., Singh V., Ahmad I., Patel H., Gupta V., Haque S. In silico analysis to identify potential antitubercular molecules in Morus alba through virtual screening and molecular dynamics simulations // Journal of Biomolecular Structure and Dynamics. – 2023. – № 13. – P. 1-8. https://doi.org/10.1080/07391102.2023.2209648Khan M., Khan S., Alshammary F., Zaidi S., Singh V., Ahmad I., Patel H., Gupta V., Haque S. In silico analysis to identify potential antitubercular molecules in Morus alba through virtual screening and molecular dynamics simulations // Journal of Biomolecular Structure and Dynamics. – 2023. – № 13. – P. 1-8. https://doi.org/10.1080/07391102.2023.2209648Koklesova L., Liskova A., Samec M., Zhai K., Al-Ishaq R.K., Bugos O., Šudomová M., Biringer K., Pec M., Adamkov M. et al. Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention // International Journal of Molecular Sciences. – 2021. – Vol. 22, № 16. – Р. 8649. https://doi.org/10.3390/ijms22168649Koklesova L., Liskova A., Samec M., Zhai K., Al-Ishaq R.K., Bugos O., Šudomová M., Biringer K., Pec M., Adamkov M. et al. Protective Effects of Flavonoids Against Mitochondriopathies and Associated Pathologies: Focus on the Predictive Approach and Personalized Prevention // International Journal of Molecular Sciences. – 2021. – Vol. 22, № 16. – Р. 8649. https://doi.org/10.3390/ijms22168649Koysomboon S., van Altena I., Kato S., Chantrapromma K. Antimycobacterial Flavonoids from Derris Indica // Phytochemistry. – 2006. – Vol. 67, № 10. – Р. 1034-1040. https://doi.org/10.1016/j.phytochem.2006.03.019Koysomboon S., van Altena I., Kato S., Chantrapromma K. Antimycobacterial Flavonoids from Derris Indica // Phytochemistry. – 2006. – Vol. 67, № 10. – Р. 1034-1040. https://doi.org/10.1016/j.phytochem.2006.03.019Kuete V., Ngameni B., Simo C.C.F., Tankeu R.K., Ngadjui B.T., Meyer J.J.M., Lall N., Kuiate J.R. Antimicrobial Activity of the Crude Extracts and Compounds from Ficus Chlamydocarpa and Ficus Cordata (Moraceae) // Journal of Ethnopharmacology. – 2008. – Vol. 120, № 1. – Р. 17-24. https://doi.org/10.1016/j.jep.2008.07.026Kuete V., Ngameni B., Simo C.C.F., Tankeu R.K., Ngadjui B.T., Meyer J.J.M., Lall N., Kuiate J.R. Antimicrobial Activity of the Crude Extracts and Compounds from Ficus Chlamydocarpa and Ficus Cordata (Moraceae) // Journal of Ethnopharmacology. – 2008. – Vol. 120, № 1. – Р. 17-24. https://doi.org/10.1016/j.jep.2008.07.026Kolloli A., Subbian S. Host-Directed Therapeutic Strategies for Tuberculosis // Frontiers in Medicine. – 2017. – Vol. 4. – Р. 171. https://doi.org/10.3389/fmed.2017.00171Kolloli A., Subbian S. Host-Directed Therapeutic Strategies for Tuberculosis // Frontiers in Medicine. – 2017. – Vol. 4. – Р. 171. https://doi.org/10.3389/fmed.2017.00171Liu F., Wang L.Y., Yu M.C., Li Y.T., Wu Z.Y., Yan C.W. A new cocrystal of isoniazid-quercetin with hepatoprotective effect: The design, structure, and in vitro/in vivo performance evaluation // European Journal of Pharmaceutical Sciences. – 2020. – № 144. – Р. 105216. https://doi.org/10.1016/j.ejps.2020.105216Liu F., Wang L.Y., Yu M.C., Li Y.T., Wu Z.Y., Yan C.W. A new cocrystal of isoniazid-quercetin with hepatoprotective effect: The design, structure, and in vitro/in vivo performance evaluation // European Journal of Pharmaceutical Sciences. – 2020. – № 144. – Р. 105216. https://doi.org/10.1016/j.ejps.2020.105216Luo M., Tian R., Yang Z., Peng Y.Y., Lu N. Quercetin suppressed NADPH oxidase-derived oxidative stress via heme oxygenase-1 induction in macrophages // Archives of Biochemistry and Biophysics. – 2019. – Vol. 671. – Р. 69-76. https://doi.org/10.1016/j.abb.2019.06.007Luo M., Tian R., Yang Z., Peng Y.Y., Lu N. Quercetin suppressed NADPH oxidase-derived oxidative stress via heme oxygenase-1 induction in macrophages // Archives of Biochemistry and Biophysics. – 2019. – Vol. 671. – Р. 69-76. https://doi.org/10.1016/j.abb.2019.06.007Murillo J., Encarnación-Dimayuga R., Malmstrøm J., Christophersen C., Franzblau S.G. Antimycobacterial Flavones from Haplopappus Sonorensis // Fitoterapia. – 2003. – Vol. 74, № 3. – Р. 226-230. https://doi.org/10.1016/S0367-326X(03)00033-9Murillo J., Encarnación-Dimayuga R., Malmstrøm J., Christophersen C., Franzblau S.G. Antimycobacterial Flavones from Haplopappus Sonorensis // Fitoterapia. – 2003. – Vol. 74, № 3. – Р. 226-230. https://doi.org/10.1016/S0367-326X(03)00033-9Namdaung U., Aroonrerk N., Suksamrarn S., Danwisetkanjana K., Saenboonrueng J., Arjchomphu W., Suksamrarn A. Bioactive Constituents of the Root Bark of Artocarpus Rigidus Subsp. Rigidus // Chemical and Pharmaceutical Bulletin. – 2006. – Vol. 54, № 10. – Р. 1433–1436. https://doi.org/10.1248/cpb.54.1433Namdaung U., Aroonrerk N., Suksamrarn S., Danwisetkanjana K., Saenboonrueng J., Arjchomphu W., Suksamrarn A. Bioactive Constituents of the Root Bark of Artocarpus Rigidus Subsp. Rigidus // Chemical and Pharmaceutical Bulletin. – 2006. – Vol. 54, № 10. – Р. 1433–1436. https://doi.org/10.1248/cpb.54.1433Navolokin N.A., Polukonova N.V., Maslyakova G.N., Bucharskaya A.B., Durnova N.A. Effect of extracts of Gratiola officinalis and Zea mays on the tumor and the morphology of the internal organs of rats with trasplanted liver cancer // Russian Open Medical Journal. – 2012. – Vol. 1, № 2. – Р. 0203. https://doi.org/10.15275/rusomj.2012.0203Navolokin N.A., Polukonova N.V., Maslyakova G.N., Bucharskaya A.B., Durnova N.A. Effect of extracts of Gratiola officinalis and Zea mays on the tumor and the morphology of the internal organs of rats with trasplanted liver cancer // Russian Open Medical Journal. – 2012. – Vol. 1, № 2. – Р. 0203. https://doi.org/10.15275/rusomj.2012.0203Nguyen Q.H., Contamin L., Nguyen T.V.A., Bañuls A.-L. Insights into The Processes That Drive the Evolution of Drug Resistance in Mycobacterium tuberculosis // Evolutionary Applications. – 2018. – Vol. 11, № 9. – Р. 1498-1511. https://doi.org/10.1111/eva.12643Nguyen Q.H., Contamin L., Nguyen T.V.A., Bañuls A.-L. Insights into The Processes That Drive the Evolution of Drug Resistance in Mycobacterium tuberculosis // Evolutionary Applications. – 2018. – Vol. 11, № 9. – Р. 1498-1511. https://doi.org/10.1111/eva.12643Pawar A., Jha P., Chopra M., Chaudhry U., Ghosh P., Singh R., Priyadarshi R., Saran S., Khan K., Dwivedi V.P. et al. Screening of natural compounds that targets glutamate racemase of Mycobacterium tuberculosis reveals the anti-tubercular potential of flavonoids // Scientific Reports. – 2020. – № 10. – Р. 949. https://doi.org/10.1038/s41598-020-57658-8Pawar A., Jha P., Chopra M., Chaudhry U., Ghosh P., Singh R., Priyadarshi R., Saran S., Khan K., Dwivedi V.P. et al. Screening of natural compounds that targets glutamate racemase of Mycobacterium tuberculosis reveals the anti-tubercular potential of flavonoids // Scientific Reports. – 2020. – № 10. – Р. 949. https://doi.org/10.1038/s41598-020-57658-8Preda M., Tanase B.C., Zob D.L., Gheorghe A.S., Lungulescu C.V., Dumitrescu E.A., Stanculeanu D.L., Manolescu L.S.C., Popescu O., Ibraim E., et al. The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer // International Journal of Environmental Research and Public Health. – 2023. – Vol. 20, № 2. – Р. 1282. https://doi.org/10.3390/ijerph20021282Preda M., Tanase B.C., Zob D.L., Gheorghe A.S., Lungulescu C.V., Dumitrescu E.A., Stanculeanu D.L., Manolescu L.S.C., Popescu O., Ibraim E., et al. The Bidirectional Relationship between Pulmonary Tuberculosis and Lung Cancer // International Journal of Environmental Research and Public Health. – 2023. – Vol. 20, № 2. – Р. 1282. https://doi.org/10.3390/ijerph20021282Rabaan A.A., Alhumaid S., Albayat H., Alsaeed M., Alofi F.S., Al-Howaidi M.H., Turkistani S.A., Alhajri S.M., Alahmed H.E., Alzahrani A.B., Mashraqi M.M., Alwarthan S., Alhajri M., Alshahrani F.S., Almuthree S.A., Alsubki R.A., Abuzaid A.A., Alfaresi M., Al Fares M.A., Mutair A.A. Promising Antimycobacterial Activities of Flavonoids against Mycobacterium sp. Drug Targets: A Comprehensive Review // Molecules. – 2022. – Vol. 27, № 16. – Р. 5335. https://doi.org/10.3390/molecules27165335Rabaan A.A., Alhumaid S., Albayat H., Alsaeed M., Alofi F.S., Al-Howaidi M.H., Turkistani S.A., Alhajri S.M., Alahmed H.E., Alzahrani A.B., Mashraqi M.M., Alwarthan S., Alhajri M., Alshahrani F.S., Almuthree S.A., Alsubki R.A., Abuzaid A.A., Alfaresi M., Al Fares M.A., Mutair A.A. Promising Antimycobacterial Activities of Flavonoids against Mycobacterium sp. Drug Targets: A Comprehensive Review // Molecules. – 2022. – Vol. 27, № 16. – Р. 5335. https://doi.org/10.3390/molecules27165335Sasikumar K., Ghosh A.R., Dusthackeer A. Antimycobacterial potentials of quercetin and rutin against Mycobacterium tuberculosis H37Rv // 3 Biotech. – 2018. – Vol. 8, № 10. – Р. 427. https://doi.org/10.1007/s13205-018-1450-5Sasikumar K., Ghosh A.R., Dusthackeer A. Antimycobacterial potentials of quercetin and rutin against Mycobacterium tuberculosis H37Rv // 3 Biotech. – 2018. – Vol. 8, № 10. – Р. 427. https://doi.org/10.1007/s13205-018-1450-5Shabir I., Kumar Pandey V., Shams R., Dar A.H., Dash K.K., Khan S.A., Bashir I., Jeevarathinam G., Rusu A.V., Esatbeyoglu T., Pandiselvam R. Promising bioactive properties of quercetin for potential food applications and health benefits: A review // Frontiers in Nutrition. – 2022. – Vol. 9. – Р. 999752. https://doi.org/10.3389/fnut.2022.999752Shabir I., Kumar Pandey V., Shams R., Dar A.H., Dash K.K., Khan S.A., Bashir I., Jeevarathinam G., Rusu A.V., Esatbeyoglu T., Pandiselvam R. Promising bioactive properties of quercetin for potential food applications and health benefits: A review // Frontiers in Nutrition. – 2022. – Vol. 9. – Р. 999752. https://doi.org/10.3389/fnut.2022.999752Shamsudin N.F., Ahmed Q.U., Mahmood S., Shah S.A.A., Khatib A., Mukhtar S., Alsharif M.A., Parveen H., Zakaria Z.A. Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation // Molecules. – 2022. – Vol. 27, № 4. – Р. 1149. https://doi.org/10.3390/molecules27041149Shamsudin N.F., Ahmed Q.U., Mahmood S., Shah S.A.A., Khatib A., Mukhtar S., Alsharif M.A., Parveen H., Zakaria Z.A. Antibacterial Effects of Flavonoids and Their Structure-Activity Relationship Study: A Comparative Interpretation // Molecules. – 2022. – Vol. 27, № 4. – Р. 1149. https://doi.org/10.3390/molecules27041149Shirokov A., Grinev V., Kanevskiy M., Fedonenko Y., Matora L., Polukonova N., Mudrak D., Mylnikov A., Polukonova A., Bucharskaya A., Navolokin N., Maslyakova G. Composition and biological activity of flavonoid-containing fractions of an extract from Gratiola officinalis L. // Anti-Cancer Agents in Medicinal Chemistry. – 2024. – № 25. https://doi.org/10.2174/0118715206302902240429072639Shirokov A., Grinev V., Kanevskiy M., Fedonenko Y., Matora L., Polukonova N., Mudrak D., Mylnikov A., Polukonova A., Bucharskaya A., Navolokin N., Maslyakova G. Composition and biological activity of flavonoid-containing fractions of an extract from Gratiola officinalis L. // Anti-Cancer Agents in Medicinal Chemistry. – 2024. – № 25. https://doi.org/10.2174/0118715206302902240429072639Singh D.K., Tousif S., Bhaskar A., Devi A., Negi K., Moitra B., Das G. Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis // PLoS Pathogens. – 2020. – Vol. 16, № 8. – Р. e1008995. https://doi.org/10.1371/journal.ppat.1008995Singh D.K., Tousif S., Bhaskar A., Devi A., Negi K., Moitra B., Das G. Luteolin as a potential host-directed immunotherapy adjunct to isoniazid treatment of tuberculosis // PLoS Pathogens. – 2020. – Vol. 16, № 8. – Р. e1008995. https://doi.org/10.1371/journal.ppat.1008995Swain S.S., Rout S.S., Sahoo A., Oyedemi S.O., Hussain T. Antituberculosis, antioxidant and cytotoxicity profiles of quercetin: a systematic and cost-effective in silico and in vitro approach // Natural Product Research. – 2022. – Vol. 36, № 18. – Р. 4763-4767. https://doi.org/10.1080/14786419.2021.2008387Swain S.S., Rout S.S., Sahoo A., Oyedemi S.O., Hussain T. Antituberculosis, antioxidant and cytotoxicity profiles of quercetin: a systematic and cost-effective in silico and in vitro approach // Natural Product Research. – 2022. – Vol. 36, № 18. – Р. 4763-4767. https://doi.org/10.1080/14786419.2021.2008387Törün T., Güngör G., Özmen I., Bölükbaşı Y., Maden E., Bıçakçı B., Ataç G., Sevim T., Tahaoğlu K. Side Effects Associated with the Treatment of Multidrug-Resistant Tuberculosis // The International Journal of Tuberculosis and Lung Disease. – 2005. – Vol. 9, № 12. – Р. 1373-1377.Törün T., Güngör G., Özmen I., Bölükbaşı Y., Maden E., Bıçakçı B., Ataç G., Sevim T., Tahaoğlu K. Side Effects Associated with the Treatment of Multidrug-Resistant Tuberculosis // The International Journal of Tuberculosis and Lung Disease. – 2005. – Vol. 9, № 12. – Р. 1373-1377.Wang T.-Y., Li Q., Bi K.-S. Bioactive Flavonoids in Medicinal Plants: Structure, Activity and Biological Fate // Asian Journal of Pharmaceutical Sciences. – 2017. – Vol. 13, № 1. – Р. 12–23. https://doi.org/10.1016/j.ajps.2017.08.004 50. WHO Global tuberculosis report 2022. – 2022. Available at: https://www.who.int/publications/i/item/9789240061729 [Accessed 27.09.2024]Wang T.-Y., Li Q., Bi K.-S. Bioactive Flavonoids in Medicinal Plants: Structure, Activity and Biological Fate // Asian Journal of Pharmaceutical Sciences. – 2017. – Vol. 13, № 1. – Р. 12–23. https://doi.org/10.1016/j.ajps.2017.08.004 50. WHO Global tuberculosis report 2022. – 2022. Available at: https://www.who.int/publications/i/item/9789240061729 [Accessed 27.09.2024]World Health Organization. Global tuberculosis report 2023. Geneva: WHO Press; 2023. Available at: https://www.who.int/teams/global-tuberculosis-programme/tb-reports [Accessed 20.08.2024]World Health Organization. Global tuberculosis report 2023. Geneva: WHO Press; 2023. Available at: https://www.who.int/teams/global-tuberculosis-programme/tb-reports [Accessed 20.08.2024]Yang K., Lamprecht S.A., Liu Y., Shinozaki H., Fan K., Leung D., Newmark H., Steele V.E., Kelloff G.J., Lipkin M. Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon // Carcinogenesis. – 2000. – Vol. 21, № 9. – Р. 1655-1660. https://doi.org/10.1093/carcin/21.9.1655Yang K., Lamprecht S.A., Liu Y., Shinozaki H., Fan K., Leung D., Newmark H., Steele V.E., Kelloff G.J., Lipkin M. Chemoprevention studies of the flavonoids quercetin and rutin in normal and azoxymethane-treated mouse colon // Carcinogenesis. – 2000. – Vol. 21, № 9. – Р. 1655-1660. https://doi.org/10.1093/carcin/21.9.1655Zhang Y. The Magic Bullets and Tuberculosis Drug Targets // Annual Review of Pharmacology and Toxicology. – 2005. – Vol. 45. – Р. 529-564. https://doi.org/10.1146/annurev.pharmtox.45.120403.100120Zhang Y. The Magic Bullets and Tuberculosis Drug Targets // Annual Review of Pharmacology and Toxicology. – 2005. – Vol. 45. – Р. 529-564. https://doi.org/10.1146/annurev.pharmtox.45.120403.100120Zhang Y., Post-Martens K., Denkin S. New Drug Candidates and Therapeutic Targets for Tuberculosis Therapy // Drug Discovery Today. – 2006. – Vol. 11, № 1-2. – Р. 21-27. https://doi.org/10.1016/S1359-6446(05)03626-3Zhang Y., Post-Martens K., Denkin S. New Drug Candidates and Therapeutic Targets for Tuberculosis Therapy // Drug Discovery Today. – 2006. – Vol. 11, № 1-2. – Р. 21-27. https://doi.org/10.1016/S1359-6446(05)03626-3Zumla A., Chakaya J., Centis R., D’Ambrosio L., Mwaba P., Bates M., Mwaba P., Kapata N., Schaaf H.S., Zijenah L.S. et al. Tuberculosis treatment and management – an update on treatment regimens, trials, new drugs, and adjunct therapies // The Lancet Respiratory Medicine. – 2015. – Vol. 3, № 3. – Р. 220-234. https://doi.org/10.1016/S2213-2600(15)00063-6Zumla A., Chakaya J., Centis R., D’Ambrosio L., Mwaba P., Bates M., Mwaba P., Kapata N., Schaaf H.S., Zijenah L.S. et al. Tuberculosis treatment and management – an update on treatment regimens, trials, new drugs, and adjunct therapies // The Lancet Respiratory Medicine. – 2015. – Vol. 3, № 3. – Р. 220-234. https://doi.org/10.1016/S2213-2600(15)00063-6Zumla A., Gillespie S.H., Hoelscher M., Philips P.P.J., Cole S.T., Abubakar I., McHugh T.D., Schito M., Maeurer M., Nunn A.J. New Antituberculosis Drugs, Regimens, and Adjunct Therapies: Needs, Advances, and Future Prospects // The Lancet Infectious Diseases. – 2014. – Vol. 14, № 4. – Р. 327-340. https://doi.org/10.1016/S1473-3099(13)70328-1Zumla A., Gillespie S.H., Hoelscher M., Philips P.P.J., Cole S.T., Abubakar I., McHugh T.D., Schito M., Maeurer M., Nunn A.J. New Antituberculosis Drugs, Regimens, and Adjunct Therapies: Needs, Advances, and Future Prospects // The Lancet Infectious Diseases. – 2014. – Vol. 14, № 4. – Р. 327-340. https://doi.org/10.1016/S1473-3099(13)70328-1

The authors declare that there are no conflicts of interest present.