tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2025-103-5-102-111tiblj-1915Research ArticleОБЗОРREVIEWНейтрофильные внеклеточные ловушки и туберкулез: патогенетическая роль и особенности формированияNeutrophil Extracellular Traps and Tuberculosis: Pathogenetic Role and Formation Patternshttps://orcid.org/0000-0001-6196-7256МордыкА. В.MordykA. V.

Мордык Анна Владимировна - д. м. н., профессор, заведующий кафедрой фтизиатрии, пульмонологии и инфекционных болезней.

644099, Омск, ул. Ленина, д. 12

Тел.: +7 (3812) 95-70-01

Anna V. Mordyk - Doctor of Medical Sciences, Professor, Head of Department of Phthisiology, Pulmonology and Infectious Diseases.

12, Lenina St., Omsk, 644099

Phone: +7 (3812) 95-70-01

amordik@mail.ruhttps://orcid.org/0000-0003-0208-3017ИвановаО. Г.IvanovaO. G.

Иванова Ольга Георгиевна - д. м. н., доцент, профессор кафедры фтизиатрии, пульмонологии и инфекционных болезней.

644099, Омск, ул. Ленина, д. 12

Тел.: +7 (3812) 95-70-01

Olga G. Ivanova - Doctor of Medical Sciences, Associate Professor of Department of Phthisiology, Pulmonology and Infectious Diseases.

12, Lenina St., Omsk, 644099

Phone: +7 (3812) 95-70-01

olga-ivanova1969@mail.ruhttps://orcid.org/0000-0002-6775-323XЗолотовА. Н.ZolotovA. N.

Золотов Александр Николаевич - к. м. н., старший научный сотрудник центральной научно-исследовательской лаборатории.

644099, Омск, ул. Ленина, д. 12

Тел.: +7 (3812) 95-70-01

Aleksandr N. Zolotov - Candidate of Medical Sciences, Senior Researcher of Central Research Laboratory.

12, Lenina St., Omsk, 644099

Phone: +7 (3812) 95-70-01

azolotov@mail.ruРомановаМ. А.RomanovaM. A.

Романова Мария Алексеевна - к. м. н., доцент кафедры фтизиатрии, пульмонологии и инфекционных болезней.

644099, Омск, ул. Ленина, д. 12

Тел.: +7 (3812) 95-70-01

Maria A. Romanova - Candidate of Medical Sciences, Associate Professor of Department of Phthisiology, Pulmonology and Infectious Diseases.

12, Lenina St., Omsk, 644099

Phone: +7 (3812) 95-70-01

rmaril@mail.ruhttps://orcid.org/0000-0002-2830-161XПтухинА. О.PtukhinA. O.

Птухин Александр Олегович - аспирант кафедры фтизиатрии, пульмонологии и инфекционных болезней.

644099, Омск, ул. Ленина, д. 12

Тел.: +7 (3812) 95-70-01

Aleksandr O. Ptukhin - Post-Graduate Student of Department of Phthisiology, Pulmonology and Infectious Diseases.

12, Lenina St., Omsk, 644099

Phone: +7 (3812) 95-70-01

phtysiatria-omsk@mail.ruhttps://orcid.org/0000-0002-4339-2222НовиковД. Г.NovikovD. G.

Новиков Дмитрий Георгиевич - к. м. н., заведующий центральной научно-исследовательской лабораторией.

644099, Омск, ул. Ленина, д. 12

Тел.: +7 (3812) 95-70-01

Dmitriy G. Novikov - Candidate of Medical Sciences, Head of Central Research Laboratory.

12, Lenina St., Omsk, 644099

Phone: +7 (3812) 95-70-01

Novikov.dm.omsk@gmail.comФГБОУ ВО «Омский государственный медицинский университет» Минздрава РоссииРоссияOmsk State Medical University, Russian Ministry of HealthRussian Federation2025051120251035102111Copyright © Мордык А.В., Иванова О.Г., Золотов А.Н., Романова М.А., Птухин А.О., Новиков Д.Г., 20252025Мордык А.В., Иванова О.Г., Золотов А.Н., Романова М.А., Птухин А.О., Новиков Д.Г.Mordyk A.V., Ivanova O.G., Zolotov A.N., Romanova M.A., Ptukhin A.O., Novikov D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1915

В обзоре приведен анализ 69 источников литературы, посвященных обсуждению механизмов формирования нейтрофильных внеклеточных ловушек при различных инфекционных и неинфекционных заболеваниях. Показаны особенности образования нейтрофильных внеклеточных ловушек при активном туберкулезе органов дыхания, их роль в патогенезе распространенных деструктивных форм заболевания. Приведены сведения о возрастных особенностях нетозоформирующей функции нейтрофилов при туберкулезной инфекции.

The review analyzes 69 publications discussing formation mechanisms of neutrophil extracellular traps in various infectious and non-infectious diseases. It depicts patterns of formation of neutrophil extracellular traps in active respiratory tuberculosis and their role in the pathogenesis of disseminated destructive forms of the disease. It provides information on age-related characteristics of the neutrophil net-forming function in tuberculosis infection.

нетознейтрофильные внеклеточные ловушкиM. tuberculosisфагоцитозфункциональная активность нейтрофиловтуберкулез органов дыханияnetosisneutrophil extracellular trapsM. tuberculosisphagocytosisfunctional activity of neutrophilsrespiratory tuberculosisОбзор подготовлен в рамках выполнения НИР «Технологии пациентоориентированного ведения больных различных возрастных групп детей и взрослых с латентной туберкулезной инфекцией, лекарственно чувствительным и лекарственно устойчивым туберкулезом с различным индексом коморбидности на основе углубленной оценки функциональных характеристик нейтрофильных лейкоцитов и подбора адъювантов химиотерапии», №ГР 124021500060-1 от 15.02.2024 г., по Государственному заданию Минздрава России (Соглашение от 24.01.2024 г. № 056-03-2024-054; Государственное задание № 056-00066-24-00 от 28.12.2023 г.).This review was prepared within the Project on Patient-Oriented Technologies for Management of Patients of Various Age Groups, Including Children and Adults with Latent Tuberculosis Infection, Drug-Sensitive and Drug-Sustainable Tuberculosis with a Different Comorbidity Index Based on Functional Characteristics of Neutrophilic Leukocytes and the Selection of Chemotherapy Adjuvants, No. GR 124021500060-1 as of February 15, 2024, according to the State Assignment of the Russian Ministry of Health (Agreement No. 056-03-2024-054 as of January 01, 2024; State Assignment No. 056-00066-24-00 as of December 28, 2023).ReferencesВоробьева Н.В., Черняк Б.В. 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The authors declare that there are no conflicts of interest present.