tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологии10.58838/2075-1230-2025-103-6-88-95tiblj-1937Research ArticleОБЗОРЫREVIEWSФенотипическое определение спектра лекарственной чувствительности Mycobacterium tuberculosis на основе применения микобактериофаговPhenotypic Testing of Drug Susceptibility Spectrum of Mycobacterium tuberculosis Based on MycobacteriophagesЛапенковаМ. Б.LapenkovaM. B.

Лапенкова Марина Борисовна - К. м. н., научный сотрудник научной лаборатории иммунопатологии и иммунодиагностики туберкулезной инфекции

127473, Москва, ул. Достоевского, д. 4, к. 2Тел.+7 (495) 631-15-15

Marina B. Lapenkova - Candidate of Medical Sciences, Researcher of Research Laboratory of Immunopathology and Immunodiagnostics of Tuberculosis Infection

Build. 2, 4 Dostoevskiy St., Moscow, 127473Phone: +7 (495) 631-15-15

manyshik@list.ruВладимирскийМ. А.VladimirskiyM. A.

Владимирский Михаил Александрович - Д. м. н., профессор, заведующий научной лабораториейиммунопатологии и иммунодиагностики туберкулезной инфекции

127473, Москва, ул. Достоевского, д. 4, к. 2Тел.+7 (495) 631-15-15

Mikhail A. Vladimirskiy - Doctor of Medical Sciences, Professor, Head of Research Laboratory of Immunopathology and Immunodiagnostics of Tuberculosis Infection

Build. 2, 4 Dostoevskiy St., Moscow, 127473Phone: +7 (495) 631-15-15

mvladimirskij@mail.ruРыбинаО. А.RybinaO. A.

Рыбина Ольга Александровна - Лаборант-исследователь научной лаборатории иммунопатологии и иммунодиагностики туберкулезной инфекции

127473, Москва, ул. Достоевского, д. 4, к. 2Тел.+7 (495) 631-15-15

Olga A. Rybina - Research Assistant of Research Laboratory of Immunopathology and Immunodiagnostics of Tuberculosis Infection

Build. 2, 4 Dostoevskiy St., Moscow, 127473Phone: +7 (495) 631-15-15

olga.rybin@mail.ruФГБУ «Национальный медицинский исследовательский центр фтизиопульмонологии и инфекционных заболеваний» МЗ РФРоссияNational Medical Research Center of Phthisiopulmonology and Infectious Diseases, Russian Ministry of HealthRussian Federation20251001202610368895Copyright © Лапенкова М.Б., Владимирский М.А., Рыбина О.А., 20262026Лапенкова М.Б., Владимирский М.А., Рыбина О.А.Lapenkova M.B., Vladimirskiy M.A., Rybina O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/1937

В последние годы возрос интерес к фаговым технологиям как к перспективным методам быстрого определения спектра лекарственной чувствительности бактерий, в том числе Mycobacterium tuberculosis. Микобактериофаги способны специфически инфицировать M. tuberculosis, что дает возможность разработки новых эффективных, экономичных диагностических тестов, а также принципиально новых лекарственных препаратов для лечения туберкулеза. Проанализированы 27 источников, описывающие основные методы, используемые для определения спектра лекарственной чувствительности M. tuberculosis с помощью микобактериофагов. Преимуществом этих методов являются: быстрота (получение результатов за 24-96 часов с момента начала анализа); специфичность (основаны на строгом круге хозяев фага). Это позволяет в короткие сроки выявлять наличие возбудителя туберкулеза и его лекарственную чувствительность к противотуберкулезным препаратам. 

In recent years, much attention has been paid to phage technologies as promising methods for rapid testing of drug susceptibility of bacteria, including Mycobacterium tuberculosis. Mycobacteriophages are capable to infect specifically M. tuberculosis, which makes it possible to develop new effective, cost-efficient diagnostic tests, as well as fundamentally new drugs for tuberculosis treatment. This review analyzes twenty-seven publications describing main methods for testing the spectrum of drug susceptibility of M. tuberculosis based in mycobacteriophages. The advantages of these methods are the following: rapidness (results are obtained within 24-96 hours from the test start), and specificity (based on a strict host range of the phage). This allows for the rapid detection of M. tuberculosis and its susceptibility to anti-tuberculosis drugs. 

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The authors declare that there are no conflicts of interest present.