tibljТуберкулез и болезни легкихTuberculosis and Lung Diseases2075-12302542-1506Медицинские знания и технологииtiblj-853Research ArticleОБЗОРЫREVIEWSАутофагия в патогенезе туберкулезаAUTOPHAGY IN THE PATHOGENESIS OF TUBERCULOSISЧечушковА. В.ChechushkovA. V.

научный сотрудник,

630117 г. Новосибирск, ул. Тимакова, д. 2

Novosibirsk

achechushkov@gmail.comЗенковН. К.ZenkovN. K.

Novosibirsk

noemail@neicon.ruКожинП. М.KozhinP. M.

Novosibirsk

noemail@neicon.ruКолпаковаТ. А.KolpakovaT. A.

Novosibirsk

noemail@neicon.ruМеньщиковаЕ. Б.Men'schikovaE. B.

Novosibirsk

noemail@neicon.ruФГБНУ «НИИ экспериментальной и клинической медицины»РоссияResearch Institute of Experimental and Clinical MedicineRussian FederationФГБНУ «НИИ экспериментальной и клинической медицины»РоссияНовосибирский НИИ туберкулеза МЗ РФ; ГБОУ ВПО «Новосибирский государственный медицинский университет» МЗ РФРоссияNovosibirsk Tuberculosis Research Institute; Novosibirsk State Medical UniversityRussian Federation201601032016943819Copyright © Чечушков А.В., Зенков Н.К., Кожин П.М., Колпакова Т.А., Меньщикова Е.Б., 20162016Чечушков А.В., Зенков Н.К., Кожин П.М., Колпакова Т.А., Меньщикова Е.Б.Chechushkov A.V., Zenkov N.K., Kozhin P.M., Kolpakova T.A., Men'schikova E.B.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.tibl-journal.com/jour/article/view/853

Аутофагия - важный иммунный механизм, определяющий устойчивость организма к внутриклеточным патогенам и, в частности, к микобактерии туберкулеза. При этом аутофагия участвует в непосредственной элиминации патогена, контроле иммунных реакций организма и поддержании внутриклеточного гомеостаза, что важно для персистенции микобактерий. Ингибирование аутофагии на ранних этапах инфицирования вирулентными штаммами микобактерий является одной из причин несостоятельности иммунного ответа, и механизмы, лежащие в основе этого процесса, рассматриваются как перспективная область для поиска патогенетически ориентированных подходов профилактики и терапии туберкулеза.

Autophagy is an important immune mechanism defining the host resistance to intracellular pathogens and tuberculous mycobacteria in particular. Autophagy is involved into direct elimination of the pathogenic agent, control of immune reactions of the host and maintenance of intracellular homeostasis which is important for mycobacterial persistence. Inhibition of autophagy at the early stages of infection by virulent mycobacterial strains is one of the reasons of poor immune response, and mechanisms defining this response are considered to be promising field to search for approaches centered at the pathogen for the tuberculosis prevention and treatment.

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The authors declare that there are no conflicts of interest present.