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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">tiblj</journal-id><journal-title-group><journal-title xml:lang="ru">Туберкулез и болезни легких</journal-title><trans-title-group xml:lang="en"><trans-title>Tuberculosis and Lung Diseases</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2075-1230</issn><issn pub-type="epub">2542-1506</issn><publisher><publisher-name>Медицинские знания и технологии</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.21292/2075-1230-2016-94-11-30-37</article-id><article-id custom-type="elpub" pub-id-type="custom">tiblj-953</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ОПЫТ НЕЙРОХИРУРГИЧЕСКОЙ ПОМОЩИ ВИЧ-позитивным БОЛЬНЫМ С ЛОКАЛЬНЫМИ ФОРМАМИ ТУБЕРКУЛЕЗА ЦЕНТРАЛЬНОЙ НЕРВНОЙ СИСТЕМЫ</article-title><trans-title-group xml:lang="en"><trans-title>NEUROSURGICAL CARE FOR HIV-INFECTED PATIENTS WITH LOCAL FORMS OF TUBERCULOSIS OF CENTRAL NERVOUS SYSTEM</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новицкая</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Novitskaya</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующая кафедрой фтизиопульмонологии,</p><p>664003 г. Иркутск, ул. Красного Восстания, д. 1</p></bio><bio xml:lang="en"><p>Head of Phthisiopulmonology Department,</p><p>1, Krasnogo Vosstaniya St., Irkutsk, 664003</p></bio><email xlink:type="simple">lga19701604@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Петров</surname><given-names>С. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Petrov</surname><given-names>S. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий нейрохирургическим отделением,</p><p>664079, г. Иркутск, м-н Юбилейный, д. 100</p></bio><bio xml:lang="en"><p>Head of Neurosurgery Department,</p><p>100, Yubileyny R.D., Irkutsk, 664079</p></bio><email xlink:type="simple">neuropet.sp@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Каня</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kanya</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>заведующий,</p><p>664059, г. Иркутск, м-н Юбилейный, д. 100</p></bio><bio xml:lang="en"><p>Head,</p><p>100, Yubileyny R.D., Irkutsk, 664059</p></bio><email xlink:type="simple">ole1587@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБОУ ВПО «Иркутский государственный медицинский университет»; ОГБУЗ «Иркутская областная клиническая туберкулезная больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk State Medical University;&#13;
Irkutsk Regional Clinical Tuberculosis Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>ГБУЗ «Иркутская областная клиническая больница»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Irkutsk Regional Clinical Hospital</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>ГУЗ «Областное патологоанатомическое бюро»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Morbid Anatomy Bureau</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2016</year></pub-date><volume>94</volume><issue>11</issue><fpage>30</fpage><lpage>37</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новицкая О.Н., Петров С.И., Каня О.В., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Новицкая О.Н., Петров С.И., Каня О.В.</copyright-holder><copyright-holder xml:lang="en">Novitskaya O.N., Petrov S.I., Kanya O.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.tibl-journal.com/jour/article/view/953">https://www.tibl-journal.com/jour/article/view/953</self-uri><abstract><sec><title>Цель исследования</title><p>Цель исследования: определение порядка взаимодействия фтизиатров и нейрохирургов при лечении локального туберкулеза ЦНС у ВИЧ-инфицированных больных.</p></sec><sec><title>Материалы и методы</title><p>Материалы и методы. Изучена гистологическая, микобактериологическая и рентгенологическая характеристики туберкулеза ЦНС у 73 умерших и 5 прооперированных ВИЧ-инфицированных пациентов.</p></sec><sec><title>Результаты</title><p>Результаты. Поэтапное лечение пациентов с локальным ВИЧ-ассоциированным туберкулезным поражением головного мозга включает консервативное лечение с поиском возбудителя в доступных биологических средах, при отсутствии эффекта от проводимой терапии - решение вопроса о биопсии с целью верификации диагноза и уточнения чувствительности возбудителя с последующим решением вопроса о радикальном удалении образования. Условием для проведения радикального оперативного вмешательства является антибактериальная подготовка в соответствии с данными о лекарственной чувствительности возбудителя до исчезновения зоны перифокального отека при нейровизуализации головного мозга.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Goal of the study</title><p>Goal of the study: to define the interaction procedure between phthisiologists and neurosurgeons when managing local tuberculosis of central nervous system in HIV-infected patients.</p></sec><sec><title>Materials and methods</title><p>Materials and methods. Histological, mycobacteriologic and X-ray features of CNS tuberculosis were studied in 73 died and 5 operated HIV-infected patients.</p></sec><sec><title>Results</title><p>Results. Stepwise treatment of the patients with local HIV-associated tuberculous lesions of brain includes conservative treatment with the search for the causative agent in all available biological liquids, and should the therapy fail then the decision is made about biopsy for diagnosis confirmation and sensitivity testing and the consequent decision about surgery aimed to remove the lesion. The surgery can be performed only after the relevant anti-bacterial treatment in compliance with drug sensitivity data till perifocal edema is not visible on the brain images. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ВИЧ-инфекция</kwd><kwd>центральная нервная система</kwd><kwd>лекарственная чувствительность</kwd><kwd>биопсия</kwd><kwd>туберкулезный абсцесс головного мозга</kwd></kwd-group><kwd-group xml:lang="en"><kwd>HIV infection</kwd><kwd>central nervous system</kwd><kwd>drug sensitivity</kwd><kwd>biopsy</kwd><kwd>cerebral tuberculous abscess</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Филиппова Т. П., Новицкая О. Н., Быков Ю. Н., Корнилова З. Х. ВИЧ-ассоциированный туберкулез центральной нервной системы в регионе с высоким уровнем распространения туберкулеза и ВИЧ-инфекции. - М.: Р.Валент, 2012. - 132 с.</mixed-citation><mixed-citation xml:lang="en">Filippova T.P., Novitskaya O.N., Bykov Yu.N., Kornilova Z.Kh. VICH-assotsiirovanny tuberkulez tsentralnoy nervnoy sistemy v regione s vysokim urovnem rasprostraneniya tuberkuleza i VICH-infektsii. [HIV-associated tuberculosis of central nervous system in the region with high prevalence of tuberculosis and HIV-infection]. Moscow, R. Valent Publ., 2012, 132 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Barr L. K., Sharer L. R., Khadka Kunwar E. et al. Intraventricular granulomatous mass associated with Mycobacterium haemophilum: A rare central nervous system manifestation in a patient with human immunodeficiency virus infection // J. Clin. Neurosci. -2015. - Vol. 22, № 6. - Р. 1057-1060. doi: 10.1016/j.jocn.2014.11.036. Epub 2015 Mar 25. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Barr L.K., Sharer L.R., Khadka Kunwar E. et al. Intraventricular granulomatous mass associated with Mycobacterium haemophilum: A rare central nervous system manifestation in a patient with human immunodeficiency virus infection. J. Clin. Neurosci., 2015, vol. 22, no. 6, pp. 1057-1060. doi: 10.1016/j.jocn.2014.11.036. Epub 2015 Mar 25. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bishburg E., Sunderam G., Reichman L. B., Kapila R. Central nervous system tuberculosis with the acquired immunodeficiency syndrome and its related complex // Ann. Intern. Med. - 1986. - Vol. 105, № 2. - Р. 210-213. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Bishburg E., Sunderam G., Reichman L.B., Kapila R. Central nervous system tuberculosis with the acquired immunodeficiency syndrome and its related complex. Ann. Intern. Med., 1986, vol. 105, no. 2, pp. 210-213. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jung E. K., Chang J. Y., Lee Y. P. et al. A case of disseminated multidrug-resistant tuberculosis involving the brain // Infect. Chemother. - 2016. - Vol. 48, № 1. - Р. 41-46. doi: 10.3947/ic.2016.48.1.41. Epub 2016 Mar 31. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Jung E.K., Chang J.Y., Lee Y.P. et al. A case of disseminated multidrug-resistant tuberculosis involving the brain. Infect. Chemother., 2016, vol. 48, no. 1, pp. 41-46. doi: 10.3947/ic.2016.48.1.41. Epub 2016 Mar 31. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lesprit P., Zagdanski A. M., de La Blanchardière A. et al. Cerebral tuberculosis in patients with the acquired immunodeficiency syndrome (AIDS). Report of 6 cases and review // Medicine (Baltimore). - 1997. - Vol. 76, № 6. - Р. 423. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Lesprit P., Zagdanski A.M., de La Blanchardière A. et al. Cerebral tuberculosis in patients with the acquired immunodeficiency syndrome (AIDS). Report of 6 cases and review. Medicine (Baltimore), 1997, vol. 76, no. 6, pp. 423. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Rajshekhar V. Surgery for brain tuberculosis: a review // Acta Neurochir (Wien). - 2015. - Vol. 157, № 10. - Р. 1665-1678. doi: 10.1007/s00701-015-2501-x. Epub 2015 Jul 14. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Rajshekhar V. Surgery for brain tuberculosis: a review. Acta Neurochir (Wien), 2015, vol. 157, no. 10, pp. 1665-1678. doi: 10.1007/s00701-015-2501-x. Epub 2015 Jul 14. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Sharma M., Velho V., Kharosekar H. A rare case of an isolated intraventricular tuberculoma with a dismal outcome: an unusual location of a common pathology and lessons learnt // Indian. J. Tuberc. - 2014. - Vol. 61, № 2. - Р. 166-170. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Sharma M., Velho V., Kharosekar H. A rare case of an isolated intraventricular tuberculoma with a dismal outcome: an unusual location of a common pathology and lessons learnt. Indian. J. Tuberc., 2014, vol. 61, no. 2, pp. 166-170. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Takeshima H., Kawahara T., Kuratsu J. Multiple meningeal tuberculomas recurring after 18-month anti-tuberculous chemotherapy-case report // Neurol. Med. Chir. (Tokyo). - 2004. - Vol. 44, № 3. - Р. 133-137. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Takeshima H., Kawahara T., Kuratsu J. Multiple meningeal tuberculomas recurring after 18-month anti-tuberculous chemotherapy-case report. Neurol. Med. Chir. (Tokyo), 2004, vol. 44, no. 3, pp. 133-137. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Vidal J. E., Hernández A. V., Oliveira A. C. et al. Cerebral tuberculomas in AIDS patients: a forgotten diagnosis? // Arq Neuropsiquiatr. - 2004. - Vol. 62, № 3B. - Р. 793-796. Epub 2004 Oct 5. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Vidal J.E., Hernández A.V., Oliveira A.C. et al. Cerebral tuberculomas in AIDS patients: a forgotten diagnosis? Arq Neuropsiquiatr., 2004, vol. 62, no. 2, pp. 793-796. Epub 2004 Oct 5. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Yadegarynia D., Merza M. A., Sali S. , Seghatoleslami Z. S. Multiple intracranial tuberculomas in a post-kidney transplant patient // Saudi. J. Kidney. Dis. Transpl. - 2016. - Vol. 27, № 1. - Р. 135-138. doi: 10.4103/1319-2442.174163. [PubMed]</mixed-citation><mixed-citation xml:lang="en">Yadegarynia D., Merza M.A., Sali S. , Seghatoleslami Z.S. Multiple intracranial tuberculomas in a post-kidney transplant patient. Saudi. J. Kidney Dis. Transpl., 2016, vol. 27, no. 1, pp. 135-138. doi: 10.4103/1319-2442.174163. [PubMed]</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Zibly Z., Levy I., Litchevski V.et al. Brain biopsy in AIDS patients: diagnostic yield and treatment applications // AIDS Res Ther. - 2014. - Vol. 11, № 4. Published online 2014 Jan 21. doi: 10.1186/1742-6405-11-4. [РМС] REFERENCES</mixed-citation><mixed-citation xml:lang="en">Zibly Z., Levy I., Litchevski V.et al. Brain biopsy in AIDS patients: diagnostic yield and treatment applications. AIDS Res Ther., 2014, vol. 11, no. 4, Published online 2014 Jan 21. doi: 10.1186/1742-6405-11-4. [РМС]</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
