IMPACT OF THE FORM OF MEDICATION ON TREATMENT ADHERENCE IN RESPIRATORY TUBERCULOSIS PATIENTS
https://doi.org/10.21292/2075-1230-2017-95-12-39-43
Abstract
The goal of the study: to investigate treatment adherence in respiratory tuberculosis patients depending on the choice of therapy.
Subjects and methods: retrospective full-design study. The case histories of adult new tuberculosis cases who were treated in TB Dispensary in 2015 were analyzed. The groups were formed based on the intake of combined drugs with fixed doses (1 tablet contained 60 mg of isoniazid, 120 mg of rifampicin, 300 mg of pyrazinamide, 225 mg of ethambutol, and 20 mg of pyridoxine) – Group 1 (n = 38); or separate tablets in the doses as per drug use instructions (isoniazid, rifampicin, pyrazinamide, ethambutol) – Group 2 (n = 78). The groups were compatible as per sex, age, and clinical manifestations of tuberculosis. Patients from Group 1 with the weight of 60 kg received 5 tablets and patients from Group 2 received more than 12 tablets. Patients' adherence to treatment was assessed as per regularity of intake and number of doses during the intensive phase of treatment.
Results. Patients from Group 1 were regularly taking anti-tuberculosis drugs, while in Group 2 there were interruptions of treatment (7-21 days) in 12 (15.4%) patients. In Group, the intensive phase increased up to 90.2 ± 30.6 doses and in Group 2 this increase made 131.6 ± 65.4 doses due to late sputum conversion. In Group 1, sputum conversion was achieved during the first month of treatment in 60% of patients; and in Group 2 – in 10% of cases (p = 0.044). The frequency of transaminase elevation as a side effect was higher in Group 1, but it did not result in discontinuation of drugs.
Thus, the intake of combined medication with fixed doses improved tuberculosis patients' adherence to treatment.
About the Authors
T. E. Tyulkova
Ural Phthisiopulmonology Research Institute,
Russian Federation
Russian Federation
Tatyana E. Tyulkova – Senior Researcher.
50, XXII Parts"ezda St., Yekaterinburg, Sverdlovsk Region, 620039
N. D. Pirogova
Regional TB Dispensary
Russian Federation
Russian Federation
Natalya D. Pirogova – Chief Doctor.
2a, Kurortnaya St., Tyumen, 625017.
R. M. Bekova
Regional TB Dispensary
Russian Federation
Russian Federation
Rumana M. Bekova – Phthisiologist
2a, Kurortnaya St., Tyumen, 625017
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Review
For citations:
Tyulkova T.E., Pirogova N.D., Bekova R.M. IMPACT OF THE FORM OF MEDICATION ON TREATMENT ADHERENCE IN RESPIRATORY TUBERCULOSIS PATIENTS. Tuberculosis and Lung Diseases. 2017;95(12):39-43. (In Russ.) https://doi.org/10.21292/2075-1230-2017-95-12-39-43
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