SKIN TESTS IN THE DIAGNOSTICS OF POST-VACCINIAL AND INFECTION ALLERGY
https://doi.org/10.21292/2075-1230-2018-96-2-27-31
Abstract
In order to investigate the duration of the post-vaccinial allergy after BCG vaccination and time of primary infection with tuberculous mycobacteria, the changes in the size of induration of Mantoux test with 2 TU PPD-L were analyzed in 806 children at the age from 5 to 7 years old with the different epidemic background The subjects were divided into 2 groups: Group 1 (n = 618) included children not exposed to tuberculosis, and Group 2 (n = 188) consisted of children with exposure to tuberculosis It was found out that the duration of the post-vaccinial allergy documented after BCG vaccination depended on the quality of immunization and epidemic factor in the child's environment (exposure to tuberculosis) In case of primary infection with tuberculosis, the response to the test with tuberculous recombinant allergen could be negative, which was more often observed in the children not exposed to tuberculosis If the child was exposed to tuberculosis, the value of the test with TRA was increasing in respect of the infectious allergy detection If the conversion of the response to tuberculin was detected, it was necessary to perform a thorough investigation of the infection history and do the test with tuberculous recombinant allergen.
About the Authors
E. P. Shilovа
Novosibirsk State Medical University, Novosibirsk
Russian Federation
Assistant of Phthisiopulmonology Department
Russian Federation
Assistant of Phthisiopulmonology Department
I. Yu. Egoshinа
Novosibirsk Regional TB Dispensary, Novosibirsk
Russian Federation
Chief Pediatric Phthisiologist of Novosibirsk Region, Head of Children Department
Russian Federation
Chief Pediatric Phthisiologist of Novosibirsk Region, Head of Children Department
L. V. Poddubnаya
Novosibirsk State Medical University, Novosibirsk
Russian Federation
Doctor of Medical Sciences, Associate Professor, Head of Phthisiopulmonology Department
Russian Federation
Doctor of Medical Sciences, Associate Professor, Head of Phthisiopulmonology Department
I. V. Pаvlenok
Novosibirsk Tuberculosis Research Institute, Novosibirsk
Russian Federation
Doctor of Research and Statistics Department
Russian Federation
Doctor of Research and Statistics Department
References
1. Аverbakh M.M., Litvinov V.I. Immunologicheskie osnovy protivotuberkuleznoy vaktsinatsii. [Immunological basics of anti-tuberculosis vaccination]. Moscow, Meditsina Publ., 1970, 211 p.
2. Аksenova V.А. et al. Actual issues of screening for tuberculosis among children. Tuberculosis and Lung Diseases, 2013, no. 3, pp. 7-8. (In Russ.)
3. Аksenova V.А., Baryshnikova L.А., Klevno N.I. Current approaches to screening of tuberculous infection in children and adolescents in Russia. Meditsinsky Soviet, 2015, no. 4, pp. 30-35. (In Russ.)
4. Аksenova V.А., Levi D.T., Fonina E.V. et al. Vaccine prevention of tuberculosis: meaning and problems. Probl. Tub., 2009, no. 1, pp. 10-16. (In Russ.)
5. Korneva N.V. et al. Comparison of results with Mantoux testing and Diaskintest in various manifestations of tuberculous infection. Tuberculosis and Lung Diseases, 2013, no. 6, pp. 49.
6. Mitinskaya L.A. 80 years of using BCG vaccine. Probl. Tub., 2001, no. 3, pp. 51-53. (In Russ.)
7. Mitinskaya L.A. Immune pathological actions of the vaccines of BCG and BCG-M. Probl. Tub., 2003, no. 3, pp. 22-23. (In Russ.)
8. Mordyk A.V. et al. Risk factors of active tuberculosis development in children (literature review). Zhizn bez opasnostey. Zdorovye. Profilaktika. Dolgoletie, 2014, vol. 9, no. 1, pp. 92-95. (In Russ.)
9. Poddubnaya L.V. BCG vaccination and its efficiency in children. Probl. Tub.,
10. , no. 1, pp. 13-16. (In Russ.)
Review
For citations:
Shilovа E.P., Egoshinа I.Yu., Poddubnаya L.V., Pаvlenok I.V. SKIN TESTS IN THE DIAGNOSTICS OF POST-VACCINIAL AND INFECTION ALLERGY. Tuberculosis and Lung Diseases. 2018;96(2):27-31. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-2-27-31
Views:
2883
Email this article 