ROLE OF PYRIDOXINE HYDROCHLORIDE IN THE DEVELOPMENT OF TOLERANCE TO THE TOXIC ACTION OF ISONIAZID IN ANIMALS
https://doi.org/10.21292/2075-1230-2018-96-6-51-57
Abstract
The objective of the study: to assess the impact of continuous and course (intermittent) use of pyridoxine hydrochloride in combination with isoniazid on the rate of tolerance development in rats under conditions of a toxicological experiment.
Subjects and methods. Isoniazid (tablets, 0.3 g.) and the substance of pyridoxine hydrochloride (powder, 50.0 g.) were used for the experiment. Male white rats were used as experimental biological models.
Main results. The article presents data on experimental study of toxicologic tolerance of rats to the anti-tuberculosis drug of isoniazid with its administration simultaneously with pyridoxine hydrochloride. The obtained data provided the evidence about the impact of pyridoxine hydrochloride on the rate of how fast the host developed the tolerance to the toxic action of isoniazid. It has been proved that intermittent (by short courses) use of pyridoxine hydrochloride with isoniazid versus its continuous use resulted in a slower development of toxicological tolerance to isoniazid in rats.
About the Authors
K. I. Usov
Research Institute of Biophysics by Angarsk State Technical University;
Irkutsk State Medical University
Russian Federation
Russian Federation
Candidate of Biological Sciences, Associate Professor, Head of Laboratory of Toxicological Tests and Testing Laboratory Center,
2, Partizanskaya St., Angarsk, Irkutsk Region, 665835
T. A. Guskova
M. V. Dorogov Center for Pharmaceutical Technology Transfer
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Correspondent Member of the Russian Academy of Sciences, Honoured Researcher of the Russian Science, Deputy Head of All-Russian Public Organization of Toxicologists, Leading Researcher of Pre-clinical Trials Department,
11/2, Tekhnoparkovaya St., Yaroslavl, 150010
G. G. Yushkov
Research Institute of Biophysics by Angarsk State Technical University
Russian Federation
Russian Federation
Candidate of Medical Sciences, Associate Professor, Researcher of Laboratory of Toxicological Tests and Testing Laboratory Center,
2, Partizanskaya St., Angarsk, Irkutsk Region, 665835
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Review
For citations:
Usov K.I., Guskova T.A., Yushkov G.G. ROLE OF PYRIDOXINE HYDROCHLORIDE IN THE DEVELOPMENT OF TOLERANCE TO THE TOXIC ACTION OF ISONIAZID IN ANIMALS. Tuberculosis and Lung Diseases. 2018;96(6):51-57. (In Russ.) https://doi.org/10.21292/2075-1230-2018-96-6-51-57
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