Specific diagnostics of infectious and inflammatory osteoarticular disorders depending on HIV status of the patient
https://doi.org/10.21292/2075-1230-2019-97-12-15-20
Abstract
The objective: to study the specific diagnostics of inflammatory lesions of the osteoarticular system depending on the patient's HIV status.
Subjects and methods. The medical records of 166 patients with signs of inflammatory changes in the osteoarticular system were analyzed. Patients were divided into groups depending on their HIV status.
Results. Tuberculosis was the major cause of osteoarticular inflammation in HIV positive patients (58.21%), while it was much less frequent in HIV negative patients (13.13%) (OR = 9.214; 95% CI 4.314; 19.680). HIV positive patients were found to have lower leukocyte counts (6.18 ± 0.24 per 109 cells/l versus 9.40 ± 0.43 per 109 cells/l in the group of HIV negative patients, p < 0.05). Tuberculous etiology of osteoarticular inflammation in patients with HIV infection was verified by microbiological methods in 43.3% of cases (95% CI 2.767; 13.472), and molecular genetic tests in 46.3% (95% CI2.722; 12.357). Invasive methods were used to obtain samples from the focus of inflammation.
About the Authors
E. O. Peretsmanas
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Evgeniy O. Peretsmanas - Doctor of Medical Sciences, Physician of Superior Metrrit, Head of Extrapulmonary Tuberculosis Research Department.
4, Dostoevsky St., Moscow, 127473
I. A. Gerasimov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Ilya A. Gerasimov - Trauma Orthopedist of Extrapulmonary Tuberculosis Department.
4, Dostoevsky St., Moscow, 127473
T. E. Tyulkova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Tatyana E. Tyulkova - Doctor of Medical Sciences, Leading Researcher.
4, Dostoevsky St., Moscow, 127473
V. S. Zubikov
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Vladimir S. Zubikov - Doctor of Medical Sciences, Professor, Leading Researcher of Extrapulmonary Tuberculosis Research Department.
4, Dostoevsky St., Moscow, 127473
G. D. Kaminskiy
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Grigoriy D. Kaminskiy - Doctor of Medical Sciences, Head of Infectious Diseases Department.
4, Dostoevsky St., Moscow, 127473
A. E. Panova
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Anna E. Panova - Candidate of Medical Sciences, Head of Laboratory Diagnostics Department.
4, Dostoevsky St., Moscow, 127473
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Review
For citations:
Peretsmanas E.O., Gerasimov I.A., Tyulkova T.E., Zubikov V.S., Kaminskiy G.D., Panova A.E. Specific diagnostics of infectious and inflammatory osteoarticular disorders depending on HIV status of the patient. Tuberculosis and Lung Diseases. 2019;97(12):15-20. (In Russ.) https://doi.org/10.21292/2075-1230-2019-97-12-15-20
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