Endobronchial valve block in the treatment of patients with destructive pulmonary tuberculosis and low adherence to therapy with anti-tuberculosis drugs and refusing to stay in hospital
https://doi.org/10.21292/2075-1230-2019-97-12-46-53
Abstract
The objective of the study: to analyze the efficacy of endobronchial valve block (EBV) during out-patient treatment of patients with destructive pulmonary tuberculosis who refused in-patient treatment and therapy with anti-tuberculosis drugs.
Subjects and methods. Treatment outcomes of 129 patients were randomly studied, the patients suffered from destructive pulmonary tuberculosis and demonstrated low adherence to therapy with anti-tuberculosis drugs and staying in hospital. EBV was used in one group (66 patients), and it was not used in patients from another group (63 patients).
Results. The use of EBV in patients with poor adherence to inpatient treatment and chemotherapy allowed achieving sputum conversion in 36 (58.1%) patients and healing of cavities in 43 (65.2%). Among the patients in whom no EBV was used, sputum conversion was achieved in 12 (20.7%) patients (p = 0.001, χ2) and cavities were healed in 14 (22.2%) patients (p = 0.001, χ2). Efficacy and safety of EBV was demonstrated when used on the out-patient basis in the above category of patients.
About the Authors
P. A. Fadeev
Zabaykalskiy Regional Clinical Phthisiopulmonary Center
Russian Federation
Russian Federation
Pavel A. Fadeev - Head Physician, Chief Expert Phthisiologist of the Far Eastern Federal District.
3, Taezhnaya St., Chita, Zabaykalskiy Kray, 672038
D. V. Krasnov
Novosibirsk Tuberculosis Research Institute; Novosibirsk State Medical University
Russian Federation
Russian Federation
Denis V. Krasnov - Doctor of Medical Sciences, Head of Pulmonary Tuberculosis Surgery Department, Head Researcher.
81a, Okhotskaya St., Novosibirsk, 630040
S. V. Sklyuev
Novosibirsk Tuberculosis Research Institute; Novosibirsk State Medical University
Russian Federation
Russian Federation
Sergey V. Sklyuev - Candidate of Medical Sciences, Head of Endoscopy Department.
81a, Okhotskaya St., Novosibirsk, 630040
N. G. Grischenko
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Nikolay G. Grischenko - Doctor of Medical Sciences, Thoracic Surgeon.
81a, Okhotskaya St., Novosibirsk, 630040
V. A. Krasnov
Novosibirsk Tuberculosis Research Institute; Novosibirsk State Medical University
Russian Federation
Russian Federation
Vladimir A. Krasnov - Doctor of Medical Sciences, Director.
81a, Okhotskaya St., Novosibirsk, 630040
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Review
For citations:
Fadeev P.A., Krasnov D.V., Sklyuev S.V., Grischenko N.G., Krasnov V.A. Endobronchial valve block in the treatment of patients with destructive pulmonary tuberculosis and low adherence to therapy with anti-tuberculosis drugs and refusing to stay in hospital. Tuberculosis and Lung Diseases. 2019;97(12):46-53. (In Russ.) https://doi.org/10.21292/2075-1230-2019-97-12-46-53
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