Systemic cytokine potential in patients with chronic obstructive pulmonary disease who completed treatment for pulmonary tuberculosis
https://doi.org/10.21292/2075-1230-2020-98-1-22-26
Abstract
The objective: to investigate the cytokine potential (TGF-β1, TNF-α, IL-1β, IL-4) in the systemic blood circulation of patients who successfully completed treatment for pulmonary tuberculosis, depending on whether they have chronic obstructive lung disease (COPD).
Subjects and methods. The study included 118 patients who had successfully completed treatment for pulmonary tuberculosis by the time of the examination. Group 1 included 79 patients with different forms of pulmonary tuberculosis without COPD, Group 2 – 39 patients with different forms of pulmonary tuberculosis and concurrent COPD. The Control Group consisted of 24 healthy individuals.
In all patients, the levels of IL-1β, TNF-α and IL-4, as well as the active form of TGF-β1 were tested in the systemic blood circulation using commercial ELISA test systems.
Results. By the time of successful tuberculosis treatment completion, COPD patients were found to develop the following: a special Th2-associated form of immune imbalance characterized by the reduced systemic level of TNF-α in combination with the increased level of IL-4; the increased risk of development and progression of pulmonary fibrosis due to the high level of growth factor TGF-β1 (in comparison with patients without COPD); elevated levels of TGF-β1 (compared with patients without COPD), creating favorable endogenous conditions for tuberculosis relapse.
About the Authors
A. A. Khrenov
S.I. Georgievsky Medical Academy of V.I. Vernadsky Crimean Federal University, Russian Ministry of Education and Science
Russian Federation
Russian Federation
Aleksandr A. Khrenov – Doctor of Medical Sciences, Professor, Head of Propedeutics of Internal Diseases Department.
5/7, Lenina Blv., Simferopol, Crimea, 295006
Phone: +7 (3652) 55-49-11.
Email: office@ma.cfuv.ru
V. M. Fedoseeva
S.I. Georgievsky Medical Academy of V.I. Vernadsky Crimean Federal University, Russian Ministry of Education and Science
Russian Federation
Russian Federation
Viktoria M. Fedoseeva – Candidate of Medical Sciences, Associate Professor, Associate Professor of Propedeutics of Internal Diseases Department.
5/7, Lenina Blv., Simferopol, Crimea, 295006
Phone: +7 (3652) 55-49-11.
Email: office@ma.cfuv.ru
M. M. Grishin
State budgetary health care institution «Crimean republican centre of Phthisiology and Pulmonology»
Russian Federation
Russian Federation
Mikhail М. Grishin – phthisiatrician.
297577, Republic of Crimea, Simferopol region, Mayskaya street, 1A.
Phone: +7 (978) 723-25-95
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Review
For citations:
Khrenov A.A., Fedoseeva V.M., Grishin M.M. Systemic cytokine potential in patients with chronic obstructive pulmonary disease who completed treatment for pulmonary tuberculosis. Tuberculosis and Lung Diseases. 2020;98(1):22-26. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-1-22-26
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