Vitamin D deficiency in children with latent tuberculosis infection
https://doi.org/10.21292/2075-1230-2020-98-6-27-31
Abstract
The objective: to assess the level of vitamin D and parameters of phosphorus-calcium metabolism in children with latent tuberculosis infection.
Subjects and methods. 40 children from 3 to 17 years were enrolled in the study, they all had the abnormal reaction to Mantoux test with 2 TU but no clinical, radiological and bacteriological signs of active tuberculosis; 39 of them received preventive treatment for latent tuberculosis infection during the study. The following parameters were tested: blood level of 25-hydroxycholecalciferol (calcidiol, 25(OH)D) (the level of less than 10 ng/ml was considered as pronounce severe deficiency, the level of 11-20 ng/ml as moderate deficiency, 21-29 ng/ml – minor deficiency, above 30 ng/ml – an adequate level of vitamin D); total calcium, and ionized calcium.
Results: 87.5% (14/16) of children from the group of 3-6 years old and 96% (23/24) of children from the group of 7-17 years old were found to have vitamin D deficiency; p > 0.05. The blood level of total calcium and ionized calcium in all children was within the age norm.
About the Authors
D. M. Slаschevа
Tyumen State Medical University
Russian Federation
Russian Federation
Darya M. Slascheva, Postgraduate student, Department of Public Health and Health Care, Institute of Continuing Professional Development.
54, Odesskaya St., Tyumen, 625023.
Phone: +7 (3452) 20-92-39.
A. D. Petrushinа
Tyumen State Medical University
Russian Federation
Russian Federation
Antonina D. Petrushina, Doctor of Medical Sciences, Professor, Head of the Department of Pediatrics, Institute for Continuing Professional Development.
54, Odesskaya St., Tyumen, 625023.
Phone: +7 (3452) 28-75-93.
N. S. Brynzа
Tyumen State Medical University
Russian Federation
Russian Federation
Natalya S. Brynza, Doctor of Medical Sciences, Associate Professor, Head of Department of Public Health and Health Care, Institute of Continuing Professional Development.
54, Odesskaya St., Tyumen, 625023.
Phone: +7 (3452) 20-92-39.
А. P. Chernovа
Regional Clinical TB Dispensary, Tyumen
Russian Federation
Russian Federation
Anna P. Chernova, Phthisiologist.
2A, Kurortnaya St., Tyumen, 625000.
N. D. Pirogovа
Regional Clinical TB Dispensary, Tyumen
Russian Federation
Russian Federation
Natalya D. Pirogova, Head Physician.
2A, Kurortnaya St., Tyumen, 625000.
Phone: +7 (3452) 43-35-89.
S. V. Sosnovskаya
Regional Clinical TB Dispensary, Tyumen
Russian Federation
Russian Federation
Svetlana V. Sosnovskaya, Head of Policlynic Department.
2A, Kurortnaya St., Tyumen, 625000.
Phone: +7 (3452) 43-43-68.
References
1. Аksenova V.А., Levi D.T., Аleksandrova N.V., Kudlay D.А. Current tuberculosis incidence in children, agents for the infection prevention and diagnostics. Biopreparaty. Profilaktika, Diagnostika, Lechenie, 2017, vol. 17, no. 3, pp. 145-151. (In Russ.)
2. Maltsev S.V., Shakirova E.M., Safina L.Z., Zakirova А.M., Suleymanova Z. Ya. Vitamin D assessment of children and adolescents. Pediatriya. Journal im. G.N. Speranskogo, 2014, vol. 93, no. 5, pp. 32-38. (In Russ.)
3. Natsionalnaya programma Nedostatochnost vitamina D u detey i podrostkov Rossiyskoy Federatsii: sovremennye podkhody k korrektsi. Soyuz pediatrov Rossii i dr. [National Program on Vitamin D Deficiency in Children and Adolescents of the Russian Federation: Modern Approaches to Its correction. Union of Pediatricians of Russia et al.]. Moscow, Pediatr Publ., 2018, 96 p.
4. Slogotskaya L.V., Bogorodskaya E.M., Senchikhina O.Yu., Nikitina G.V., Kudlay D.А. Formation of risk groups among children facing an advanced risk to develop tuberculosis who should undergo various immunological examinations. Rossiyskiy Pediatricheskiy Journal, 2017, vol. 20, no. 4, pp. 207-213. (In Russ.)
5. Slogotskaya L.V., Sinitsyn M.V., Kudlay D.А. Possibilities of immunological tests in the diagnosis of latent tuberculosis infection and tuberculosis. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 11, pp. 46-59. (In Russ.)
6. Starshinova А.А., Kudlay D.А., Dovgalyuk I.F., Basantsova N.Yu., Zinchenko Yu.S., Yablonskiy P.K. Efficacy of new methods of immunodiagnostics of tuberculous infection in the Russian Federation. Pediatriya, 2019, vol. 98, no. 44, pp. 229-235. (In Russ.) doi: 10.24110/0031-403X-2019-98-4-229-235.
7. Federalnye klinicheskie rekomendatsii po diagnostike i lecheniyu latentnoy tuberkuleznoy infektsii u detey. [Federal clinical guidelines on diagnostics and treatment of latent tuberculous infection in children]. Moscow, ROOI Zdorovye Cheloveka Publ., 2015, 36 p.
8. Shilin D.E. Hormone vitamin D in the clinic of the XXI century: pleiotropic effects and laboratory assessment (lecture). Klinicheskaya Laboratornaya Diagnostika, 2010, no. 12, pp. 17-23. (In Russ.)
9. Arnedo-Pena et al. Latent tuberculosis infection, tuberculin skin test and vitamin D status in contacts of tuberculosis patients: a cross-sectional and case-control study. BMC Infectious Diseases, 2011, no. 11, pp. 349.
10. Khoo A.L., Chai L.Y. Vitamin D(3) down-regulates proinflammatory cytokine response to Mycobacterium tuberculosis through pattern recognition receptors while inducing protective cathelicidin production. Cytokine, 2011, vol. 55, no. 2, pp. 294-300.
11. Larcombe L., Orr P., Tumer-Brannen E., Slivinski C.R., Nickerson P.W., Mookhegee N. Effect of vitamin D supplementation on Mycobacterium tuberculosis-induced innate immune responses in a Canadian Dené First Nations Cohort. PLoS One, 2012, vol. 7, no. 7.
12. Nnoaham K.E., Clarke A. Low serum vitamin D levels and tuberculosis: a systematic review and meta-analysis. Int. J. Epidemiol., 2008, vol. 37, no. 1, pp. 113-119.
13. Shovkun L., Aksenova V., Kudlay D., Sarychev A. The role of immunological tests in the diagnosis of tuberculosis infection in children with juvenile idiopathic arthritis (JIA). Eur. Respir. J., 2018, vol. 52, no. S62, PA2733.
14. Slogotskaya L.V., Bogorodskaya E., Sentchichina O., Ivanova D., Nikitina G., Litvinov V., Seltsovsky P., Kudlay D.A., Nikolenko N., Borisov S. Effectiveness of tuberculosis detection using a skin test with allergen recombinant (CFP-10-ESAT-6) in children. Eur. Respir. J., 2015, vol. 46, no. S59, РА4524.
15. Slogotskaya L.V., Litvinov V., Kudlay D.A., Ovsyankina E., Seltsovsky P., Ivanova D., Nikolenko N. New skin test with recombinant protein CFP10-ESAT6 in patients (children and adults) with tuberculosis, non-tuberculosis disease and latent TB infection. Eur. Respir. J., 2012, vol. 40, no. S56, pp. 416.
16. Slogotskaya L.V., Litvinov V., Ovsyankina E., Seltsovsky P., Kudlay D. Results of QuantiFERON-TB Gold in-tube and skin testing with recombinant proteins CFP-10-ESAT-6 in children and adolescents with TB or latent TB infection. Paediatr. Respir. Rev., 2013, vol. 14, no. 2, pp. S65.
17. Sundaram M.E., Coleman L.A. Vitamin D and influenza. Adv. Nutr., 2012, vol. 3, no. 4, pp. 517-525.
Review
For citations:
Slаschevа D.M., Petrushinа A.D., Brynzа N.S., Chernovа А.P., Pirogovа N.D., Sosnovskаya S.V. Vitamin D deficiency in children with latent tuberculosis infection. Tuberculosis and Lung Diseases. 2020;98(6):27-31. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-6-27-31
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