Clinical signs of tuberculosis relapses in HIV patients
https://doi.org/10.21292/2075-1230-2020-98-6-32-35
Abstract
The objective: to study clinical manifestations of tuberculosis relapses and their treatment outcomes in patients with HIV infection.
Subjects and Methods. 132 medical records of patients with tuberculosis relapses were analyzed; 69 of them were HIV-positive and 63 were HIV-negative. All of them were admitted to Irkutsk Regional Clinical Tuberculosis Hospital from 2016 to 2019, and then continued treatment of tuberculosis on the out-patient basis. Treatment efficacy was assessed in February 2020.
Results. More severe clinical forms of tuberculosis relapses were typical of HIV patients including generalized forms affecting the central nervous system. Therefore, among these patients, the mortality rate is significantly higher (24.6%) than in tuberculosis relapses with no concurrent HIV infection (6.3%), p ≤ 0.05.
About the Authors
E. Yu. ZorkаltsevаRussian Federation
Elena Yu. Zorkaltseva, Doctor of Medical Sciences, Professor, Head of Phthisiology and Infectious Diseases Department.
100, Yubileyny Mikroraion St., Irkutsk, 664049.
Yu. O. Egorovа
Russian Federation
Yulia O. Egorova, Post Graduate Student of Tuberculosis and Infectious Diseases Department.
100, Yubileyny Mikroraion St., Irkutsk, 664049.
References
1. Golubchikov P.N., Kruk E.А., Mishustin S.P., Petrenko T.I., Kudlay D.А. Experience of treating extensive drug resistant tuberculosis patients including continuous use of bedaquiline, in Tomsk Region: immediate and postponed results. Tuberculosis and Lung Diseases, 2019, vol. 97, no. 8, pp. 38-45. (In Russ.)
2. Pokrovskiy V.V., Ladnaya N.N., Sokolova E.V. HIV-infection and tuberculosis in Russia: "both are worse". Tuberculosis and Lung Diseases, 2014, no. 6, pp. 3-8. (In Russ.)
3. Slogotskaya L.V., Litvinov V.I., Seltsovskiy P.P., Shuster А.M., Martyanov V.А., Kudlay D.А., Filippov А.V., Kochetkov Ya.А.Use of the skin test with recombinant tuberculous allergen (Diaskintest) for diagnostics of tuberculous infection in HIV patients. Pulmonoloiya, 2011, no. 1, pp. 60-64. (In Russ.) https://doi.org/10.18093/0869-0189-2011-0-1-60-64.
4. Tikhonova L.Yu., Sokolova V.V., Tarasyuk I.А., Ekimenko А.M., Cherenkova M.А., Kudlay D.А.Experience of treatment of multiple drug resistant tuberculosis patients with bedaquiline in Amur Region. Tuberculosis and Lung Diseases, 2018, vol. 96, no. 6, pp. 45-50. (In Russ.)
5. Eysmont N.V, Senin А.M. Tuberculosis relapses in HIV patients. Ftisiatriya i Pulmonologiya, 2013, no. 1, pp. 28. (In Russ.)
6. Post F.A., Grint D., Werlinrud A.M., Panteleev A., Riekstina V., Malashenkov E.A. Multi-drug-resistant tuberculosis in HIV positive patients in Eastern Europe. J. Infect., 2014, vol. 68, no. 3, pp. 259-263.
Review
For citations:
Zorkаltsevа E.Yu., Egorovа Yu.O. Clinical signs of tuberculosis relapses in HIV patients. Tuberculosis and Lung Diseases. 2020;98(6):32-35. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-6-32-35