The impact of the infection caused by hepatitis B and C on the characteristics of hepatotoxic reactions in tuberculosis patients
https://doi.org/10.21292/2075-1230-2020-98-7-26-30
Abstract
The objective of the study: to identify the specific parameters of hepatotoxic reactions in tuberculosis patients depending on the presence of hepatitis B and C markers in the blood.
Subjects and methods. The state of the hepatobiliary system was studied in 107 HIV-negative patients with newly diagnosed infiltrative pulmonary tuberculosis in the destructive phase. The main group included 52 people with positive results of the tests for markers of viral hepatitis B and C, the comparison group included 55 people with negative results. The groups were compatible in age, volume of the lung tissue lesions, and drug resistance profile.
Results. Even before the start of anti-tuberculosis therapy, in the main group had elevated levels of cholinesterase and blood amylase, ultrasound examination detected hyperechoic liver parenchyma, enlarged right lobe of the liver, liver veins fibrosis, the enlarged diameter of the cystic duct and splenic vein, and splenomegaly (p <0.05), which was statistically significantly more frequent than in the comparison group. In the course of treatment, patients of both groups developed hepatotoxic reactions, however, in the main group they were more frequent versus the comparison group (88.4 and 21.8%, respectively, p <0.05), appeared earlier on average by 14 days and were accompanied by more pronounced clinical manifestations and abnormalities of biochemical parameters.
About the Authors
V. V. Dantsev
S. M. Kirov Military Medical Academy
Russian Federation
Russian Federation
Vladimir V. Dantsev, Doctor of Medical Sciences, Head of Phthisiology Department
93, Toreza Ave., St. Petersburg, 194214
Phone: +7 (812) 554-14-08
R. D. Muchaidze
S. M. Kirov Military Medical Academy
Russian Federation
Russian Federation
Ruben D. Muchaidze, Teacher
93, Toreza Ave., St. Petersburg, 194214
Phone: +7 (812) 554-14-08
L. R. Levina
Municipal Tuberculosis Hospital no. 2
Russian Federation
Russian Federation
Larisa R. Levina, Deputy Head Doctor for Epidemiological Activities
93, Toreza Ave., St. Petersburg, 194214
Phone: +7 (812) 576-38-68
M. G. Spitsyn
S. M. Kirov Military Medical Academy
Russian Federation
Russian Federation
Mikhail G. Spitsyn, Candidate of Medical Sciences, Associate Professor of Phthisiology Department
93, Toreza Ave., St. Petersburg, 194214
Phone: +7 (812) 554-14-08
V. S. Tokmakov
S. M. Kirov Military Medical Academy
Russian Federation
Russian Federation
Vasiliy S. Tokmakov, Candidate of Medical Sciences, Senior Teacher
93, Toreza Ave., St. Petersburg, 194214
Phone: +7 (812) 554-14-08
Phone: +7 (812) 292-34-20
G. S. Balasanyants
S. M. Kirov Military Medical Academy
Russian Federation
Russian Federation
Goar S. Balasanyants, Doctor of Medical Sciences, Professor
93, Toreza Ave., St. Petersburg, 194214
Phone: +7 (812) 554-14-08
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Review
For citations:
Dantsev V.V., Muchaidze R.D., Levina L.R., Spitsyn M.G., Tokmakov V.S., Balasanyants G.S. The impact of the infection caused by hepatitis B and C on the characteristics of hepatotoxic reactions in tuberculosis patients. Tuberculosis and Lung Diseases. 2020;98(7):26-30. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-7-26-30
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