Clinical and economic aspects of enhanced treatment efficacy of multiple drug resistant tuberculosis
https://doi.org/10.21292/2075-1230-2020-98-9-50-54
Abstract
The objective of the study: To evaluate the clinical and economic efficacy of chemotherapy in patients with newly diagnosed multiple drug resistant tuberculosis (MDR).
Subjects and methods. The number and structure of MDR tuberculosis patients living on the territory of the Republic of Karelia from 2008 to 2017 were studied. The clinical and economic efficacy of treatment of MDR tuberculosis patients was assessed.
Results. In 2011-2017, decrease in the number of MDR patients in the Republic of Karelia was mainly due to enhanced treatment efficacy of new MDR tuberculosis cases. The introduction of social support methods (food parsels) and express drug sensitivity testing to rifampicin using the Gene Xpert MTB/RIF was associated with higher treatment efficacy – from 37.2% (2013) to 58% (2014), the lower rate of treatment defaults, and significant decrease in mortality, as well as reduction of costs for curing of one MDR tuberculosis patient from1.68 million rubles in 2012 up to 0.77 million rubles in 2014.
About the Authors
Yu. M. Markelov
Petrozavodsk State University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Associate Professor, Professor of the Faculty Department for Therapy, Phthisiology, Infectious Diseases and Epidemiology,
33, Lenina Ave., Petrozavodsk, 185910
A. S. Lesonen
Petrozavodsk State University
Russian Federation
Russian Federation
Candidate of Pharmaceutical Sciences, Associate Professor of the Department of Pharmacology, Organization and Economics of Pharmacy,
33, Lenina Ave., Petrozavodsk, 185910
References
1. Vasilyeva I.А., Belilovsky E.M., Borisov S.E., Sterlikov S.А. MDR tuberculosis in the Russian Federation and other countries. Tuberculosis and Lung Diseases, 2017, vol. 95, no. 11, pp. 5-19. (In Russ.)
2. Markelov Yu.M. Clinical and epidemiological specifics of multiple drug resistant tuberculosis and causes of its transmission in Karelia. Tuberculosis and Lung Diseases, 2011, no. 8, pp. 11-17. (In Russ.)
3. Markelov Yu.M., Vyazovaya А.А., Zhuravlev V.Yu., Maryandyshev А.O. Genotyping characteristics of multiple drug resistant tuberculous mycobacteria in Karelia. Uchenye Zapiski Petrozavodskogo Gosudarstvennogo Universiteta, Seriya Estestvennye i Tekhnicheskie Nauki, 2010, no. 6 (111), pp. 31-33. (In Russ.)
4. Markelov Yu.M., Lesonen А.S., Kostina O. Clinical and economic efficiency of using polymerase chain reaction – Gene Xpert method in the diagnosis and treatment of multiple drug resistant tuberculosis. Farmakoekonomika: Teoriya i Praktika, 2019, vol. 7, no. 1, pp. 57-58. (In Russ.)
Review
For citations:
Markelov Yu.M., Lesonen A.S. Clinical and economic aspects of enhanced treatment efficacy of multiple drug resistant tuberculosis. Tuberculosis and Lung Diseases. 2020;98(9):50-54. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-9-50-54
Views:
734
Email this article 