The outbreak of the new coronavirus infection in pediatric TB department
M. F. Gubkina,
I. Yu. Petrakova,
N. V. Yukhimenko,
S. S. Sterlikova,
Yu. Yu. Khokhlova,
R. B. Аmansakhedov https://doi.org/10.21292/2075-1230-2020-98-10-6-10
Abstract
The objective: to analyze the course of the new coronavirus infection (COVID-19) in children with active respiratory tuberculosis.
Subjects and methods. The article describes results of retrospective analysis of the course of the new coronavirus infection in 25 children (3-12 years old) with active respiratory tuberculosis during the outbreak of COVID-19 in an in-patient TB unit.
Results. 24 (96%) persons got infected after the close exposure to the coronavirus infection, and 1 (4%) child didn't get infected. The diagnosis was verified by polymerase chain reaction (detection of RNK of SARS-CoV-2) in 33.3%, by enzyme immunoassay (detection of IgG antibodies to SARS-CoV-2 in 1 month after quarantine removal) in 100%. 58.3% of children with respiratory tuberculosis (14 people) infected with coronavirus infection had minimal respiratory symptoms, that did not differ from signs of other respiratory viral infections; clinical manifestations of the disease were completely absent in 41.7% (10) patients. Coronavirus pneumonia was diagnosed in 4 (16.7%) children who suffered from COVID-19, they had no clinical signs of lower respiratory tract disorders and no body temperature increase; 3 patients had no signs of respiratory viral infection; in all cases, the lung damage detected by computed tomography didn't exceed 10%. In 2 months after the removal of quarantine, no IgG antibodies to SARS-CoV-2 were detected in 2 out of 10 examined children (20.0%), thus there was a chance for re-infection. No mutual aggravating effect of coronavirus infection and tuberculosis was revealed in their combination over the entire observation period (4 months).
About the Authors
M. F. Gubkina
Central Tuberculosis Research Institute, Moscow; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Chief Researcher of Children and Adolescents Departmen
2, Yauzskaya Alleya, Moscow, 107564
I. Yu. Petrakova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of Junior Children Department
2, Yauzskaya Alleya, Moscow, 107564
N. V. Yukhimenko
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences, Leading Researcher of Children and Adolescents Department
2, Yauzskaya Alleya, Moscow, 107564
S. S. Sterlikova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Junior Children Department
2, Yauzskaya Alleya, Moscow, 107564
Yu. Yu. Khokhlova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Junior Children Department
2, Yauzskaya Alleya, Moscow, 107564
R. B. Аmansakhedov
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Candidate of Medical Sciences, Head of X-Ray Diagnostics Department of Respiratory Disorders and Rehabilitation Center
2, Yauzskaya Alleya,Moscow, 107564
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For citations:
Gubkina M.F., Petrakova I.Yu., Yukhimenko N.V., Sterlikova S.S., Khokhlova Yu.Yu., Аmansakhedov R.B. The outbreak of the new coronavirus infection in pediatric TB department. Tuberculosis and Lung Diseases. 2020;98(10):6-10. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-10-6-10
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