Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study
https://doi.org/10.21292/2075-1230-2020-98-10-33-40
Abstract
The objective: to compare the results of follow-up over patients with a mild form of pulmonary sarcoidosis who received alpha-tocopherol and those receiving no treatment.
Subjects and methods. The results of follow-up over 80 sarcoidosis patients were retrospectively analyzed – two groups of 40 patients enrolled according to the copy – pair principle (gender, age, initial X-ray stage, Löfgren syndrome, and follow-up duration). The only sign that statistically distinguished the groups was a high frequency of complaints about weakness in those who received vitamin E – 55% versus 30% (p < 0.05). The follow-up period for patients in both groups was a year or more (a control point). The database was maintained and processed using SPSS-18, Windows 10. A clear advantage of vitamin E administration was revealed when comparing the data of computed tomography, which resulted in improvement in 87.5%, and the disease progressed in 2.5%, while in the group receiving no treatment – 60 and 12.5%, respectively. The OR of improvement in computed tomography with alpha-tocopherol versus the group receiving no treatment made 4.67 (95% CI, 1.51-14.46).
Conclusion. The use of vitamin E in mild forms of thoracic sarcoidosis gives a better result compared to the group receiving no treatment.
About the Authors
A. A. Vizel
Kazan State Medical University
Russian Federation
Russian Federation
Doctor of Medical Sciences, Professor, Head of Phthisiopulmonology Department
49, Butlerova St., Kazan, 420012
D. A. Culver
Department of Pulmonary Medicine, Respiratory Institute, Inflammation and Immunity Department, Lerner Research Institute, Cleveland Clinic
United States
United States
Director of interstitial Diseases and Sarcoidosis Program of Cleveland Clinic WASOG President
Mail Code A90 9500 Euclid Avenue Cleveland, OH 44195
I. Yu. Vizel
Kazan State Medical University; Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Doctor of Medical Sciences, Associate Professor of Phthisiopulmonology Department
49, Butlerova St., Kazan, 420012
G. R. Shakirova
Kazan State Medical University; Republican Clinical Hospital, the Ministry of Health of Tatarstan Republic
Russian Federation
Russian Federation
Candidate of Medical Sciences, Assistant of Phthisiopulmonology Department
49, Butlerova St., Kazan, 420012
E. A. Bakunina
The Hospice Charity Fund «Vera»
Russian Federation
Russian Federation
Physician
4, 2nd Nikoloschepovskiy Lane, Moscow, 121099
References
1. Kostina Z.I., Аfanasiev I.V., Grigorieva V.I. Sarkoidoz legkikh. [Pulmonary sarcoidosis]. Leningrad, Meditsina Publ., 1975, 186 p.
2. Raznatovskaya E.N. Integral indices of endogenous intoxication in patients with drug resistant pulmonary tuberculosis. Аktualnі Pitannya Farmatsevtichnoy I Medichnoy Nauki Ta Praktiki, 2012, vol. 9, no. 2, pp. 119-120.
3. Sarkaidoz. [Sarcoidosis]. А.G. Khomenko, O. Shvayger, eds., Moscow, Meditsina Publ., 1982, 296 p.
4. Tyumentseva Z.G., Tereshina L.S. A clinical case of successful treatment of sarcoidosis of the intrathoracic lymph nodes with alpha-tocopherol as monotherapy in out-patient settings. Zdravookhraneniye Dalnego Vostoka, 2008, vol. 4, no. 36, pp. 84-86. (In Russ.)
5. Atan D., İkincioğulları A., Köseoğlu S. et al. New predictive parameters of Bell's palsy: neutrophil to lymphocyte ratio and platelet to lymphocyte ratio. Balkan. Med. J., 2015, vol. 32, no. 2, pp. 167-170.
6. Crouser E.D., Maier L.A., Wilson K.C., Bonham C.A., Morgenthau A.S., Patterson K.C., Abston E., Bernstein R.C., Blankstein R., Chen E.S., Culver D.A., Drake W., Drent M., Gerke A.K., Ghobrial M., Govender P., Hamzeh N., James W.E., Judson M.A., Kellermeyer L., Knight S., Koth L.L., Poletti V., Raman S.V., Tukey M.H., Westney G.E., Baughman R.P. Diagnosis and detection of sarcoidosis. An official American Thoracic Society Clinical Practice Guideline. Am. J. Respir. Crit. Care Med., 2020, no. 201 (8), pp. e26-e51. doi: 0.1164/rccm.202002-0251ST.
7. Hunninghake G.W., Costabel U., Ando M., Baughman R., Cordier J.F., du Bois R. et al. ATS/ERS/WASOG statement on sarcoidosis: American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasc. Diffuse Lung Dis., 1999, no. 16, pp. 149-173.
8. Kim T.K., Kang S.H., Moon H.S., Sung J.K., Jeong H.Y., Eun H.S. Pulmonary sarcoidosis that developed during the treatment of a patient with Crohn disease by using infliximab. Ann. Coloproctol., 2017, vol. 33, no. 2, pp. 74-77. doi: 10.3393/ac.2017.33.2.74.
9. Koutsokera A., Papaioannou A.I., Malli F., Kiropoulos T.S., Katsabeki A., Kerenidi T., Gourgoulianis K.I., Daniil Z.D. Systemic oxidative stress in patients with pulmonary sarcoidosis. Pulm. Pharmacol. Ther., 2009, vol. 22, no. 6, pp. 603-607. Epub 2009 Sep 9.
10. Myoren T., Kobayashi S., Oda S., Nanno T., Ishiguchi H., Murakami W., Okuda S., Okada M., Takemura G., Suga K., Matsuzaki M., Yano M. An oxidative stress biomarker, urinary 8-hydroxy-2'-deoxyguanosine, predicts cardiovascular-related death after steroid therapy for patients with active cardiac sarcoidosis. Int. J. Cardiol., 2016, no. 212, pp. 206-213. doi: 10.1016/j.ijcard.2016.03.003.
11. Pande A., Culver D.A. Knowing when to use steroids, immunosuppressants or biologics for the treatment of sarcoidosis. Expert. Rev. Respir. Med., 2020, vol. 14, no. 3, pp. 285-298. doi: 10.1080/17476348.2020.1707672.
12. Psathakis K., Papatheodorou G., Plataki M., Panagou P., Loukides S., Siafakas N.M., Bouros D. 8-Isoprostane, a marker of oxidative stress, is increased in the expired breath condensate of patients with pulmonary sarcoidosis. Chest, 2004, vol. 125, no. 3, pp. 1005-1011.
13. Rothkrantz-Kos S., Drent M., Vuil H., De Boer M., Bast A., Wouters E.F., Roos D., van Dieijen-Visser M.P. Decreased redox state in red blood cells from patients with sarcoidosis. Sarcoidosis. Vasc. Diffuse Lung Dis., 2002, vol. 19, no. 2, pp. 114-120.
Review
For citations:
Vizel A.A., Culver D.A., Vizel I.Yu., Shakirova G.R., Bakunina E.A. Assessment of the effect of alpha-tocopherol on the course of newly diagnosed pulmonary sarcoidosis: a comparative study. Tuberculosis and Lung Diseases. 2020;98(10):33-40. (In Russ.) https://doi.org/10.21292/2075-1230-2020-98-10-33-40
Views:
6131
Email this article 