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Treatment outcomes in new pulmonary tuberculosis cases depending on the main genotypes of Mycobacterium tuberculosis in the Republic of Sakha (Yakutia)

https://doi.org/10.21292/2075-1230-2021-99-1-41-47

Abstract

The objective: to study treatment efficacy in new pulmonary tuberculosis patients depending on the genotypes of M. tuberculosis in the Republic of Sakha (Yakutia).

Subjects and methods. The authors studied the clinical course and outcomes of 312 bacteriologically confirmed new pulmonary tuberculosis cases among patients admitted to hospital in 2010-2014. Molecular genetic tests included deletion analysis of RD105 and RD207 regions of DNA of the pathogen followed by MIRU-VNTR genotyping at 24 loci.

Results. In the Republic of Sakha (Yakutia), the Bejing and S genotypes are of epidemic importance, these genotypes prevail among drug resistance mycobacteria. Tuberculosis caused by the Bejing genotype had multiple (MDR) and extensive drug resistance (XDR) in 30.6% of cases, its subtype CC2/W148 - in 85.3%. The S genotype was accompanied by MDR/XDR in 69.7% of cases, subtype S256 - in 78.9%. The treatment of patients was highly efficient according to the criteria of sputum conversion (92%) and cavities healing (89.4%). The lowest rates were observed in case of tuberculosis caused by the Bejing and S genotypes due to their subtypes CC2/W148 and S256. Clinical cure of new pulmonary tuberculosis caused by the Bejing genotype was achieved in 73.4% of cases, by subtype CC2/W148 - in 41.2% with a significantly higher proportion of treatment failures and lethal outcomes of tuberculosis than in other subtypes of this genotype. With the S genotype, the clinical cure was achieved in 72.7% of patients, with no significant difference in the incidence of unfavorable outcomes in patients with subtype S256.

About the Authors

N. E. Evdokimov
Scientific Practical Phthisiology Center
Russian Federation

Nadezhda E. Evdokimova - Resident Physician of Pulmonary Tuberculosis Treatment Department.

93, P. Alekseev St., Yakutsk, 677015, Phone: +7 (4112) 44-80-33



M. K. Vinokurovа
Scientific Practical Phthisiology Center; M.K. Ammosov Medical Institute of North-Eastern Federal University
Russian Federation

Maria K. Vinokurova - Doctor of Medical Sciences, Deputy Director for Research.

93, P. Alekseev St., Yakutsk, 677015, Phone: +7 (4112) 39-03-30


S. N. Zhdаnovа
Research Center of Family Health and Reproduction Problems
Russian Federation

Svetlana N. Zhdanova - Doctor of Medical Sciences, Senior Researcher of the Laboratory of Epidemiologically and Socially Important Diseases.

16, Timiryazeva St., Irkutsk, 664003, Phone: +7 (3952) 20-73-67


O. B. Ogаrkov
Research Center of Family Health and Reproduction Problems; Irkutsk State Medical Academy of Postgraduate Education - Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation

Oleg B. Ogarkov - Doctor of Medical Sciences, Senior Researcher, Head of Epidemiology and Microbiology Department.

16, Timiryazeva St., Irkutsk, 664003, Phone: +7 (3952) 20-73-67



A. F. Krаvchenko
Scientific Practical Phthisiology Center
Russian Federation

Aleksandr F. Kravchenko - Doctor of Medical Sciences, Director.

93, P. Alekseev St., Yakutsk, 677015, Phone: +7 (4112) 47-51-59



E. D. Sаvilov
Research Center of Family Health and Reproduction Problems; Irkutsk State Medical Academy of Postgraduate Education - Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation

Evgeniy D. Savilov - Doctor of Medical Sciences, Professor, Chief Researcher of the Laboratory of Epidemiologically and Socially Important Diseases.

16, Timiryazeva St., Irkutsk, 664003, Phone: +7 (3952) 33-34-23



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Review

For citations:


Evdokimov N.E., Vinokurovа M.K., Zhdаnovа S.N., Ogаrkov O.B., Krаvchenko A.F., Sаvilov E.D. Treatment outcomes in new pulmonary tuberculosis cases depending on the main genotypes of Mycobacterium tuberculosis in the Republic of Sakha (Yakutia). Tuberculosis and Lung Diseases. 2021;99(1):41-47. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-1-41-47

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)