Radiological and morphological parallels in the course of respiratory sarcoidosis
https://doi.org/10.21292/2075-1230-2021-99-1-48-54
Abstract
The objective of the study: to study the radiological and morphological parallels in respiratory sarcoidosis (RS).
Subjects and methods. 121 patients with respiratory sarcoidosis were enrolled in the study, their ages varied from 21 to 66 years, they all were examined in 2007-2019. The analysis of radiological manifestations of sarcoidosis was assessed according to the main parameters (symmetry of the lesions, the size of the intrathoracic lymph nodes, the presence of dissemination, pneumofibrosis). The extended morphological testing of biopsy specimens was carried including evaluation of the quantitative and qualitative composition of granulomas.
Results. The chest computed tomography revealed a discrepancy between the radiation signs in respiratory sarcoidosis and the staging theory by Wurm. Changes in the lung parenchyma and swelling of the mediastinal lymph nodes were found in all patients at stages I-III. The components of the cellular elements of the inflammatory infiltrate did not differ at different stages of respiratory sarcoidosis. However, as the radiological changes progress, the number of granulomas increased and there was a direct correlation between the number of granulomas in the biopsy specimen and the X-ray staging by Wurm (r = 0.24; p <0.05), while the frequency of granulomas with necrosis also increased (r = 0.39 ; p < 0.05).
About the Authors
I. A. Palchikova
Tomsk Regional Clinical Hospital
Russian Federation
Russian Federation
Inna A. Palchikova - Pulmonologist of Therapy In-Patient Fee-for-Service Medicine Department.
96, Chernykh St., Tomsk. 634063, Phone: +7 (3822) 63-00-26O. A. Denisova
Siberian State Medical University
Russian Federation
Russian Federation
Olga A. Denisova - Assistant at Hospital Therapy Department with Training Course on Physical Rehabilitation and Sport Medicine, Rheumatologist of Rheumatology Department of Therapeutic Clinic.
2, Moskovsky Tr., Tomsk. 634050, Phone: +7 (3822) 90-91-01 (ext.1104)
G. M. Chernyavskaya
Siberian State Medical University
Russian Federation
Russian Federation
Galina M. Chernyavskaya - Doctor of Medical Sciences, Professor of Hospital Therapy Department of Physical Rehabilitation and Sport Medicine.
2, Moskovsky Tr., Tomsk. 634050, Phone: +7 (3822) 90-11-01 (ext.1568)
I. L. Purlik
Siberian State Medical University
Russian Federation
Russian Federation
Igor L. Purlik - Doctor of Medical Sciences, Professor of Anatomical Pathology Department.
2, Moskovsky Tr., Tomsk. 634050, Phone: +7 (3822) 90-95-15 (ext.3002)
T. P. Kalacheva
Siberian State Medical University
Russian Federation
Russian Federation
Tatiana P. Kalacheva - Assistant Professor of General Medical Practice and Polyclinic Therapy Department.
2, Moskovsky Tr., Tomsk. 634050, Phone: +7 (3822) 90-11-01 (ext.1684)
G. E. Chernogoryuk
Siberian State Medical University
Russian Federation
Russian Federation
Georgiy E. Chernogoryuk - Doctor of Medical Sciences, Professor of Hospital Therapy Department of Physical Rehabilitation and Sport Medicine.
2, Moskovsky Tr., Tomsk. 634050, Phone: +7 (3822) 90-11-01 (ext.1568)
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Review
For citations:
Palchikova I.A., Denisova O.A., Chernyavskaya G.M., Purlik I.L., Kalacheva T.P., Chernogoryuk G.E. Radiological and morphological parallels in the course of respiratory sarcoidosis. Tuberculosis and Lung Diseases. 2021;99(1):48-54. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-1-48-54
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