Photodynamic therapy in tuberculous pleural empyema
https://doi.org/10.21292/2075-1230-2021-99-5-51-56
Abstract
as a lethal outcome predictor. To enhance treatment efficacy, TPE local sanitation method utilizing antimicrobial photodynamic therapy (PDT) has been developed. This technique is based on the generation of oxygen radicals by the interaction of photosensitizers and light quanta which inactivate Mycobacterium tuberculosis and pyogenic flora. To assess the sanitizing and antimicrobial efficacy of PDT, 96 procedures were performed in 16 patients (in 14 cases, TPE was complicated by bronchopleural fistula, in 10 cases it developed after surgical treatment of pulmonary tuberculosis). After intrapleural instillation of phthalocyanine aluminum 0.5 mg, all walls of the empyema cavity were irradiated by laser radiation with the wavelength of 662 nm and light density of 30-100 J/cm2. The response to PDT of tuberculous pleural empyema was reported in 93.75% of cases (n = 15), with complete response observed in 75% of cases (n = 12).
About the Authors
S. D. Nikonov
Novosibirsk State Regional Clinical Tuberculosis Hospital; Novosibirsk Tuberculosis Research Institute; Novosibirsk State University
Russian Federation
Russian Federation
Sergey D. Nikonov, Doctor of Medical Sciences, Head of Gravitational Blood Surgery Department
14, Vavilova St., Novosibirsk, 630082
M N. Smolentsev
Novosibirsk State Regional Clinical Tuberculosis Hospital
Russian Federation
Russian Federation
Maksim N. Smolentsev, Candidate of Medical Sciences, Head of Thoracic Surgery Department
14, Vavilova St., Novosibirsk, 630082
D. V. Krasnov
Novosibirsk State Regional Clinical Tuberculosis Hospital
Russian Federation
Russian Federation
Denis V. Krasnov, Candidate of Medical Sciences, Deputy Chief Doctor for Surgery
14, Vavilova St., Novosibirsk, 630082
D. А. Bredikhin
Novosibirsk State Regional Clinical Tuberculosis Hospital; Novosibirsk State University
Russian Federation
Russian Federation
Demid A. Bredikhin, Clinical Laboratory Diagnostics Physician
14, Vavilova St., Novosibirsk, 630082
S. N. Belogorodtsev
Novosibirsk Tuberculosis Research Institute
Russian Federation
Russian Federation
Sergey N. Belogorodtsev, Leading Researcher of Experimental Laboratory Department
81a, Okhotskaya St., Novosibirsk, 630040
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Review
For citations:
Nikonov S.D., Smolentsev M.N., Krasnov D.V., Bredikhin D.А., Belogorodtsev S.N. Photodynamic therapy in tuberculous pleural empyema. Tuberculosis and Lung Diseases. 2021;99(5):51-56. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-5-51-56
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