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Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma

https://doi.org/10.21292/2075-1230-2021-99-12-38-43

Abstract

The objective of the study: to study rs2227983 polymorphism of EGFR gene in patients with allergic asthma and healthy individuals.

Subjects and Methods. 179 patients suffering from allergic asthma were included in the study. The diagnosis and degree of severity were established in accordance with the GINA recommendations. The Control Group included apparently healthy individuals (n = 217). Patients with allergic asthma underwent standard laboratory and instrumental examinations and DNA typing.

Results. A statistically significant predominance of AG genotype frequency in the group of patients with allergic asthma, including women, versus the group of healthy individuals, was established. AG rs2227983 genotype of EGFR gene was found to be significantly more common in patients with mild and moderate allergic asthma including women, than in healthy individuals, including women.

Conclusion. The association of rs2227983 polymorphism of EGFR gene with allergic asthma has been established. A homozygous GG genotype may play a protective role against the disease.

About the Authors

A. B. Аveryanov
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Anatoliy B. Аveryanov, Assistant of Faculty Therapy Department with Professional Development Training.

1, Partizana Zheleznyaka St.,Krasnoyarsk, 660022.



I. I. Cherkashina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Irina I. Cherkashina, Doctor of Medical Sciences, Professor of Faculty Therapy Department with Professional Development Training.

1, Partizana Zheleznyaka St.,Krasnoyarsk, 660022.



S. Yu. Nikulina
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Svetlana Yu. Nikulina, Doctor of Medical Sciences, Professor, Head of Faculty Therapy Department with Professional Development Training.

1, Partizana Zheleznyaka St.,Krasnoyarsk, 660022.

Phone: +7 (391) 220-04-95.



E. Yu. Kuznetsova
V. F. Voyno-Yasenetsky Krasnoyarsk State Medical University
Russian Federation

Elena Yu. Kuznetsova, Candidate of Medical Sciences, Associate Professor of Faculty Therapy Department with Professional Development Training.

1, Partizana Zheleznyaka St.,Krasnoyarsk, 660022.



V. N. Maksimov
Institute of Internal and Preventive Medicine, the Branch of Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences
Russian Federation

Vladimir N. Maksimov, Doctor of Medical Sciences, Professor, Head of Laboratory for Molecular Genetic Research of Therapeutic Diseases.

175/1, Borisa Bogatkova St., Novosibirsk, 630089.

Phone: +7 (383) 264-25-16.



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Review

For citations:


Аveryanov A.B., Cherkashina I.I., Nikulina S.Yu., Kuznetsova E.Yu., Maksimov V.N. Evaluation of the role of rs2227983 polymorphism of EGFR gene in the development of allergic asthma. Tuberculosis and Lung Diseases. 2021;99(12):38-43. (In Russ.) https://doi.org/10.21292/2075-1230-2021-99-12-38-43

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)