Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis
https://doi.org/10.21292/2075-1230-2022-100-6-17-22
Abstract
The objective: to investigate the relationship of polymorphic variants of genes of xenobiotic biotransformation metabolism enzymes (NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)), GSTM1 (E/D), GSTT1 (E/D) with the risk of pulmonary tuberculosis.
Subjects and Methods. Within the framework of this study, a population sample of unrelated 1081 individuals of Slavic nationalities (mainly Russians) living in the territory of Kursk Oblast was used.
Results. The del/del (D/D) GSTM1 genotype was associated with an increased risk of developing tuberculosis, while carrying the del/del (D/D) GSTT1 genotype was associated with a lower risk of developing the disease. Polymorphism 3435T>C ABCB1 (TC genotype) was associated with increased susceptibility to pulmonary tuberculosis in the codominization model, while TT+TC genotypes had the same association in the dominance model.
About the Authors
M. A. Alymenko
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education; Kursk Regional Health Committee
Russian Federation
Russian Federation
Maksim A. Alymenko,Candidate of Medical Sciences, Assistant of Phthisiology and Pulmonology Department
11, Mushtari St. Kazan, 420012.
R. Sh. Valiev
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Ravil Sh. Valiev, Doctor of Medical Sciences, Professor, Head of Phthisiology and Phthisiosurgery Department, Chief Phthisiologist of Volga Federal District, Honored Doctor of Russia and the Republic of Tatarstan
11, Mushtari St. Kazan, 420012.
A. V. Polonikov
Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University
Russian Federation
Russian Federation
Aleksey V. Polonikov, Professor, Director of Research Institute
of Genetic and Molecular Epidemiology
3, Karla Marksa St., Kursk, 305000
T. N. Golubeva
Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Tatiana N. Golubeva, Deputy Head Doctor on Reporting and Statistics
Village of Schetinka, Kursky Raion, Kursk Region, 305511.
Phone: +7 (4712) 34-45-06
A. P. Vasilevskaya
Regional Clinical TB Dispensary
Russian Federation
Russian Federation
Anna P. Vasilevskaya, Phthisiologist
Village of Schetinka, Kursky Raion, Kursk Region, 305511.
Phone: +7 (4712) 34-45-0
E. V. Miroshnik
Kursk Regional Health Committee
Russian Federation
Russian Federation
Elena V. Miroshnik, Leading Consultant in the Department of Medical Care Organization and Development.
6, Krasnaya Square, Kursk, 305000.
Phone: +7 (4712) 51-05-43
References
1. Belushkina N.N., Chemezov A.S., Paltsev M.A. Genetic studies of multifactorial diseases in the concept of personalized medicine. Profilakticheskaya Meditsina, 2019, no. 3, pp. 26-29. (In Russ.)
2. Bragina E.Yu. Sravnitelny analiz struktury nasledstvennoy komponenty podverzhennosti k bronkhialnoy astme i tuberkulezu po genam fermentov metabolizma ksenobiotikov. Diss. kand. biol. nauk. [Comparative analysis of genetic predisposition structure to asthma and tuberculosis as per enzyme genes of xenobiotics metabolism. Cand. Diss.]. 03.00.15. Tomsk, 2005, 140 p.
3. Gergert V.Ya., Valiev R.Sh., Chukanova V.P., Pospelov L.E., Malenko A.F., Valiev N.R. Distribution of HLA complex of antigens in tuberculosis patients and those healthy in the tatar population. Probl. Tub., 2004, no. 8, pp. 45-46. (In Russ.)
4. Zemlyakova M.A., Koldibekova Yu.V. Modern approaches to the assessment of metabolic disorders of xenobiotics when they enter the host from the external environment. Ekologiya Cheloveka, 2012, vol. 8, pp. 8-13. (In Russ.)
5. Konenkov V.I., Smolnikova M.V. Polymorphism of the promoter regions of the IL4 and 10 genes and tumor necrosis factor α in HIV-infected people. Byulleten Eksperimentalnoy Biologii i Meditsiny, 2002, vol. 133, no. 4, pp. 449-451. (In Russ.)
6. Menshikova E.B., Zenkov N.K. Modern approaches to the analysis of oxidative stress, or how to measure the immeasurable. Bulleten VSNTS SO RAMN, 2016, vol. 1, no. 3 (109), pp. 174-179. (In Russ.)
7. Polonikov A.V. Polimorfizm genov fermentov biotransformatsii ksenobiotikov i ikh kompleksnoye vliyaniye na predraspolozhennost k multifaktorialnym zabolevaniyam: Diss. dokt. med. nauk. [Polymorphism of genes of xenobiotic biotransformation enzyme and their complex effect on predisposition to multifactorial diseases. Doct. Diss.]. 03.00.15. Moscow, 2006, 442 p.
8. Puzyrev V.P., Freydin M.B., Kucher A.N. Geneticheskoye raznoobraziye narodonaseleniya i bolezni cheloveka. [Genetic diversity of the population and human diseases]. Tomsk, Pechatnaya Manufactura Publ., 2007, 320 p.
9. Churnosov M.I., Polyakova I.S., Pakhomov S.P., Orlova V.S. Molecular and genetic mechanisms of biotransformation of xenobiotics. Nauchnyye Vedomosti Belgorodskogo Universiteta, 2011, no. 16, pp. 223-228. (In Russ.)
10. Bushueva O.Yu. Single nucleotide polymorphisms in genes encoding xenobiotic metabolizing enzymes are associated with predisposition to arterial hypertension. Research Results in Biomedicine, 2020, vol. 6, no. 4, pp. 447-456. doi: 10.18413/2658-6533-2020-6-4-0-1.
11. Danielle K., Pelkonen O., Ahokas T. Hepatocytes: The powerhouse of biotransformation. The International Journal of Biochemistry & Cell Biology, 2012, vol. 44, pp. 257-265.
12. Samgina T.A. Influence of some risk factors and rs1799930 polymorphism of the NAT2-590 G>A gene on the development of chronic pancreatitis. Research Results in Biomedicine, 2021, vol. 7, no. 2, pp. 143-148. (In Russ.) doi:10.18413/2658-6533-2021-7-2-0-4.
Review
For citations:
Alymenko M.A., Valiev R.Sh., Polonikov A.V., Golubeva T.N., Vasilevskaya A.P., Miroshnik E.V. Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis. Tuberculosis and Lung Diseases. 2022;100(6):17-24. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-6-17-22
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