Tuberculosis meningitis in HIV-positive and HIV-negative patients
https://doi.org/10.21292/2075-1230-2022-100-6-38-44
Abstract
The objective: to study the epidemiological rates of tuberculous meningitis (TM) in Smolensk and Kaluga Oblasts in 2015-2020.
Subjects and Methods. 51 medical fles (Form no. 003-u) of patients with TM were analyzed, those patients were treated in in-patient settings in Smolensk and Kaluga Oblasts over a 6-year period (2015-2020).
Results. The proportion of TM signifcantly correlates with the prevalence of HIV in 2 Oblasts (r = 0.953, p = 0.140 and r = 0.978, p = 0.095, respectively), which allows stating that HIV is the main risk factor for the development of TM. Tuberculous meningitis is more common in men (70.6%) of working age (94.1%), unemployed (60.8%), in combination with pulmonary tuberculosis (64.7%). Late diagnosis of TM is registered in ⅔ of cases; patients fail to undergo the mandatory minimum diagnostic examination. Among patients with HIV infection, TM more often develops in men (90%) of working age (100%), who do not have a regular job (80%), against the background of risk factors (drug addiction, hepatitis C, experience of incarceration), duration of HIV infection up to 10 years and recurrence of tuberculosis. Among HIV positive patients, a severe state, generalized forms of tuberculosis, including lung lesions with scanty bacterial discharge in sputum are registered in 100% of cases.
About the Authors
T. V. Myakisheva
Smolensk State Medical University
Russian Federation
Russian Federation
Tatiana V. Myakisheva, Head of Phthisiopulmonology Department
38, Krupskoy St., Smolensk, 214036.
Phone: +7 (4812) 27-18-09.
SPIN-code: 3001-6222
I. S. Lapshina
Kaluga State University Named after K. E. Tsiolkovski
Russian Federation
Russian Federation
Irina S. Lapshina, Associate Professor of Internal Medicine Department of Medical Institute
85, Gorkogo St., Kaluga, 248003.
SPIN-code: 2781-0857
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Review
For citations:
Myakisheva T.V., Lapshina I.S. Tuberculosis meningitis in HIV-positive and HIV-negative patients. Tuberculosis and Lung Diseases. 2022;100(6):38-44. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-6-38-44
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