Association of Polymorphic Gene Variants of Xenobiotic Biotransformation Enzymes with Lung Tissue Destruction in Tuberculosis Patients
https://doi.org/10.21292/2075-1230-2022-100-8-25-30
Abstract
The objective: to investigate the association of polymorphic gene variants of xenobiotic biotransformation enzymes (NAT2, CYP2E1, ABCB1, GSTM1, GSTT1) and cytokines (IL1B, IL-4, IL-10, TNF) with lung tissue destruction in pulmonary tuberculosis patients.
Subjects and Methods. An ethnically homogeneous population sample of unrelated individuals of Slavic nationalities (mainly Russians) living in Kursk Oblast suffering from new pulmonary tuberculosis was examined.
Results. New pulmonary tuberculosis with no destructive changes in the lungs was associated with the EE genotype of the GSTM1 gene (p < 0.0001) in 89.5%, while the DD genotype of the GSTM1 gene (p < 0.0001) was associated with the presence of destructive changes in the lungs in 56.1% of cases; the dominant GG genotype of the TNF-α gene was associated with destructive changes in the lungs in 93.3% (p = 0.027), and the recessive GA genotype of the TNF-α gene was associated with no destructive changes in the lungs in 71.9% (p = 0.027).
About the Authors
M. A. Alymenko
Kazan State Medical Academy, Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Maksim A. Alymenko, Candidate of Medical Sciences, Assistant of Phthisiology and Pulmonology Department
11, Mushtari St., Kazan, 420012
R. Sh. Valiev
Kazan State Medical Academy, Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Ravil Sh. Valiev, Doctor of Medical Sciences, Professor, Head of Phthisiology and Pulmonology Department, Chief Phthisiologist of Volga Federal District, Honored Doctor of Russia and the Republic of Tatarstan
11, Mushtari St., Kazan, 420012
N. R. Valiev
Kazan State Medical Academy, Branch of Russian Medical Academy of Continuing Professional Education
Russian Federation
Russian Federation
Nail R. Valiev, Candidate of Medical Sciences, Associate Professor of Phthisiology and Pulmonology Department
11, Mushtari St., Kazan, 420012
A. V. Polonikov
Research Institute of Genetic and Molecular Epidemiology, Kursk State Medical University
Russian Federation
Russian Federation
Aleksey V. Polonikov, Doctor of Medical Sciences, Professor, Director
3, Karla Marksa St., Kursk, 305000
I. N. Tragira
National Medical Research Center of Phthisiopulmonology and Infectious Diseases
Russian Federation
Russian Federation
Irina N. Tragira, Chief Infectious Diseases Doctor of the Central Federal District, Head of General Infectology Center
4, Dostoevsky St., Moscow, 127473
Phone: +7 (495) 681-11-66
N. V. Sheenkov
The Gamaleya National Center of Epidemiology and Microbiology
Russian Federation
Russian Federation
Nikolay V. Sheenkov, Candidate of Medical Sciences, Senior Researcher
25, Gamaleya St., Moscow, 123098
References
1. Belushkina N.N., Chemezov A.S., Paltsev M.A. Genetic studies of multifactorial diseases in the concept of personalized medicine. Profilakticheskaya Meditsina, 2019, no. 3, pp. 26-29. (In Russ.)
2. Bikmaeva A.R., Valiakhmetova D.Kh., Khusnutdinova E.K. Polymorphism of the gene of tumor necrosis factor alpha in patients with infiltrative pulmonary tuberculosis in Bashkiria. Molekulyarnaya Biologiya, 2002, vol. 36, no. 5, pp. 784-787. (In Russ.)
3. Bodienkova G.M., Titova Zh.V. The role of polymorphism and expression of individual cytokine genes in the formation of pathology (review). Uspekhi Sovremennogo Estestvoznaniya, 2015, no. 1-4, pp. 616-620. (In Russ.) Available: https://natural-sciences.ru/ru/article/view?id=34866.
4. Konenkov V.I., Smolnikova M.V. Polymorphism of the promoter regions of the IL4 and 10 genes and tumor necrosis factor α in HIV-infected people. Byulleten Eksperimentalnoy Biologii i Meditsiny, 2002, vol. 133, no. 4, pp. 449-451. (In Russ.)
5. Mizieva S.M. The investigation of blood concentration of the tumor necrosis factors alpha of patients with herpes infections. Fundamentalnye Issledovaniya, 2009, no. 8, pp. 22-24. (In Russ.) Available: https://fundamentalresearch.ru/ru/article/view?id=1977.
6. Polonikov A.V. Polimorfizm genov fermentov biotransformatsii ksenobiotikov i ikh kompleksnoye vliyaniye na predraspolozhennost k multifaktorialnym zabolevaniyam. Diss. dokt. med. nauk. [Polymorphism of genes of xenobiotic biotransformation enzyme and their complex effect on predisposition to multifactorial diseases. Doct. Diss.]. 03.00.15. Moscow, 2006, 442 p.
7. Puzyrev V.P., Freydin M.B., Kucher A.N. Geneticheskoye raznoobraziye narodonaseleniya i bolezni cheloveka. [Genetic diversity of the population and human diseases]. Tomsk, Pechatnaya Manufactura Publ., 2007, 320 p.
8. Sartaeva G.Sh., Isaeva A.G., Rakhysheva A.A. The special role of tumor necrosis factor-alpha in the anti-tuberculosis response (literature review). Vestnik KazNMU, no. 4, 2018, pp. 69-73. (In Russ.)
9. Selvarajf S.P., Sriram A.M.U., Mathan Kurian S., Reetha A.M., Narayanan P.R. Tumour necrosis factor alpha (-238 and -308) and beta gene polymorphisms in pulmonary tuberculosis: haplotype analysis with HLA-A, B and DR genes. Tuberculosis (Edinb), 2001, vol. 81, no. 5-6, pp. 335-341.
10. Danielle К., Pelkonen О., Ahokas Т. Hepatocytes: The powerhouse of biotransformation. Int. J. Biochem. Cell Biol., 2012, no. 44, pp. 257-265.
11. Dannenberg А.М. Roles of cytotoxicdelayed-typehypersensitivity and macrophage-activating cell-mediated immunity in the pathogenesis of tuberculosis. Immunobiology, 1994, no. 191 (4-5), pp. 461-473. doi: 10.1016/S0171-2985(11)80452-3.
12. Gideon H.P., Phuah J., Myers A.J. et al. Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization. PLoS Pathog., 2015, vol. 11, no. 1, pp. e1004603.
13. Hunter R.L., Jagannath C., Actor J.K. Pathology of postprimary tuberculosis in humans аnd mice:contradiction of long-held beliefs. Tuberculosis (Edinb.), 2007, vol. 87, no. 4, 267-278. doi: 10.1016/j.tube.2006.11.003.
14. Ulfichs T., Kosmiadi G.A., Trusov V., Jörg S., Pradl L., Titukhina M., Mishenko V., Gushina N., Kaufmann S.H. Human tuberculosis granulomas induce peripheral lymphoid follicle-like structures to orchestrate local host defence in the lung. J. Pathol., 2004, no. 204, pp. 217-228. doi: 10.1002/path.1628.
Review
For citations:
Alymenko M.A., Valiev R.Sh., Valiev N.R., Polonikov A.V., Tragira I.N., Sheenkov N.V. Association of Polymorphic Gene Variants of Xenobiotic Biotransformation Enzymes with Lung Tissue Destruction in Tuberculosis Patients. Tuberculosis and Lung Diseases. 2022;100(8):25-30. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-8-25-30
Views:
438
Email this article 