Drug susceptibility of clinical isolates of Mycobacterium avium complex
https://doi.org/10.21292/2075-1230-2022-100-11-39-47
Abstract
The objective: to study drug susceptibility of M. avium and M. intracellulare isolates received from patients with mycobacteriosis residing in the North Western Federal District using the Sensititre SLOMYCO panels.
Subjects and Methods. From 2014 to 2020, 192 slow-growing MAC strains (164 – M. avium, 28 – M. intracellulare) obtained from HIV-negative patients with pulmonary mycobacteriosis were studied. Drug susceptibility testing of MAC strains was performed using the Sensititre SLOMYCO panel consisting of 13 antibacterial drugs.
Results. Of the 13 antibacterial drugs, clarithromycin was also most effective against both M. avium (67.1%; 110/164) and M. intracellulare (60.7%; 17/28) (p > 0.05). The proportion of M. avium and M. intracellulare strains sensitive to linezolid was high and amounted to 57.3 and 53.5%, as well as to amikacin – 57.3 and 53.5% respectively.
Of the four antibacterial drugs of the Sensititre SLOMYCO panel (clarithromycin, moxifloxacin, linezolid, and amikacin), for which critical concentrations (CC) were established, clarithromycin was the most effective against M. avium and M. intracellulare. Antibiotic-resistant M. avium isolates were more frequent in the group of previously treated patients.
About the Authors
D. A. Starkova
Paster St. Petersburg Research Institute of Epidemiology and Microbiology
Russian Federation
Russian Federation
Darya A. Starkova, Candidate of Biological Sciences, Senior Researcher of Molecular Epidemiology and Evolutionary Genetics Laboratory, Senior Researcher of Laboratory for Pathogen Identification
Phone: +7 (812) 233-21-49
14, Mira St., St. Petersburg, 197101
V. Yu. Zhuravlev
St. Petersburg Phthisiopulmonology Research Institute
Russian Federation
Russian Federation
Vyacheslav Yu. Zhuravlev, Candidate of Medical Sciences, Leading Researcher, Coordinator of Laboratory Diagnostics Unit, Head of Laboratory for Etiological Diagnostics
Phone: +7 (812) 775-75-55
2-4, Ligovsky Ave., St. Petersburg, 191036
N. S. Solovieva
St. Petersburg Phthisiopulmonology Research Institute,
Russian Federation
Russian Federation
Natalya S. Solovieva, Candidate of Medical Sciences, Bacteriologist of Superior Merit, Head of Bacteriological Laboratory
Phone: +7 (812) 775-75-55
2-4, Ligovsky Ave., St. Petersburg, 191036
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Review
For citations:
Starkova D.A., Zhuravlev V.Yu., Solovieva N.S. Drug susceptibility of clinical isolates of Mycobacterium avium complex. Tuberculosis and Lung Diseases. 2022;100(11):39-47. (In Russ.) https://doi.org/10.21292/2075-1230-2022-100-11-39-47
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