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Stratification of risks of tuberculosis relapses during the pandemic of the novel coronavirus infection

https://doi.org/10.58838/2075-1230-2023-101-2-87-93

Abstract

The objective: to assess risk factors for tuberculosis relapse during the COVID-19 pandemic.

Results. During the retrospective study, medical documents of patients treated for tuberculosis in 2020-2022 were analyzed. 140 patients above 18 years old with confirmed tuberculosis were included: newly diagnosed tuberculosis – 50 patients, early relapses – 50 patients, and late relapses – 40 patients. At the first stage, significant factors for relapse development were identified (ANOVA): diabetes (F=19402,8; p=0,000000), substances abuse (F=547,6; p=0,000000), alcohol abuse (F=149,7; p=0,000000), MDR MTB (F=107,8; p=0,000000), HIV infection (F=72,4; p=0,000000), imprisonment (F=49,5; p=0,000000), chronic respiratory diseases (F=47,1; p=0,000000), smoking (F=29,0; p=0,000000), and social status (F=28,9; p= 0,000000). At the second stage (cluster analysis), factors implementing the risks of development of early or late relapses were identified.

As well as before the COVID-19 pandemic, social, medical and biological risk factors play a significant role in the development of tuberculosis relapses; history of COVID-19 was not one of the risk factors; and stratification of the risk factors made it possible to identify factors that contribute to development of both early and late relapses and to determine preventive measures.

About the Authors

S. V. Smerdin
Moscow Regional Clinical TB Dispensary; M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation

Sergey V. Smerdin - Head Physician, Moscow Regional Clinical TB Dispensary

Build. 8, 7, Dubki St., Settlement of Zdravnitsa, Mytischi, Moscow Region, 141132

Phone: +7 (496) 588-41-29



N. N. Sheshelyakina
Moscow Regional Clinical TB Dispensary
Russian Federation

Natalya N. Sheshelyakina - Deputy Head Physician for Out-Patient Medical Care

Build. 8, 7, Dubki St., Settlement of Zdravnitsa, Mytischi, Moscow Region, 141132



A. I. Shevchenko
Kuban State Medical University, Russian Ministry of Health; Clinical TB Dispensary, Ministry of Health of Krasnodarsky Kray
Russian Federation

Andrey I. Shevchenko - Head Physician, Clinical TB Dispensary, Ministry of Health of Krasnodarsky Kray

95, Ayvazovskogo St., Krasnodar, Krasnodarsky Kray, 350002

Phone: +7 (861) 233-75-73



M. A. Plekhanova
Moscow Regional Clinical TB Dispensary; M. F. Vladimirsky Moscow Regional Research Clinical Institute
Russian Federation

Maria A. Plekhanova - Deputy Head Physician, Moscow Regional Clinical TB Dispensary

Build. 8, 7, Dubki St., Settlement of Zdravnitsa, Mytischi, Moscow Region, 141132

Phone: +7 (913) 664-66-20



R. I. Ludanny
Moscow Regional Clinical TB Dispensary
Russian Federation

Ruslan I. Ludanny - Biologist of Bacteriological Laboratory

Build. 8, 7, Dubki St., Settlement of Zdravnitsa, Mytischi, Moscow Region, 141132



T. I. Vorobieva
Moscow Regional Clinical TB Dispensary
Russian Federation

Tatiana I. Vorobieva - Head of Consulting and Diagnostic Department

Build. 8, 7, Dubki St., Settlement of Zdravnitsa, Mytischi, Moscow Region, 141132



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Review

For citations:


Smerdin S.V., Sheshelyakina N.N., Shevchenko A.I., Plekhanova M.A., Ludanny R.I., Vorobieva T.I. Stratification of risks of tuberculosis relapses during the pandemic of the novel coronavirus infection. Tuberculosis and Lung Diseases. 2023;101(2):87-93. (In Russ.) https://doi.org/10.58838/2075-1230-2023-101-2-87-93

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ISSN 2075-1230 (Print)
ISSN 2542-1506 (Online)