Intraspecific Diversity of Mycobacterium abscessus Isolated from Patients with Pulmonary Lesions
https://doi.org/10.58838/2075-1230-2023-101-4-40-45
Abstract
The objective: to perform intraspecific differentiation of M. abscessus strains isolated from patients with pulmonary lesions using molecular genetic tests.
Results. Intraspecific differentiation of 164 cultures of M. abscessus from 114 patients without cystic fibrosis showed that the subspecies M. abscessus subsp. dominated in the analysis set (90 of 114 patients; 78,95%), followed by M. abscessus subsp. massiliense (24/114; 21,05%). In 54 examined cystic fibrosis patients excreting non-tuberculous mycobacteria, M. abscessus was most often detected (41 patients out of 54; 75,93%). Intraspecific identification of the obtained M. abscessus isolates demonstrated the prevalence of the subspecies M. abscessus subsp. abscessus (29/41; 70,73%) over M. abscessus subsp. massiliense (11/41; 26,83%). In one case, a rare M. abscessus subsp. bolletii (1/41; 2,44%) was detected.
About the Authors
T. G. Smirnova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Tatyana G. Smirnova - Candidate of Medical Sciences, Head of Microbiology Department.
2, Yauzskaya Alleya, Moscow, 107564
Phone: +7 (499) 785-90-91
L. N. Chernousova
Central Tuberculosis Research Institute
Russian Federation
Russian Federation
Larisa N. Chernousova - Doctor of Biological Sciences, Professor, Head of Laboratory of Molecular Genetic Research, Department of Microbiology.
2, Yauzskaya Alleya, Moscow, 107564
Phone: +7 (499) 785-90-91
D. A. Varlamov
All-Russia Research Institute of Agricultural Biotechnology
Russian Federation
Russian Federation
Dmitry A. Varlamov – Researcher.
42, Timiryazevskaya St., Moscow, 127550
Phone: +7 (495) 984-69-93
D. G. Sochivko
All-Russia Research Institute of Agricultural Biotechnology
Russian Federation
Russian Federation
Dmitry G. Sochivko – Researcher.
42, Timiryazevskaya St., Moscow, 127550
Phone: +7 (495) 984-69-93
A. E. Ergeshov
Central Tuberculosis Research Institute; A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Russian Ministry of Health
Russian Federation
Russian Federation
Atadzhan Е. Ergeshov - Correspondent Member of RAS, Doctor of Medical Sciences, Professor, Director, Professor of Phthisiology and Pulmonology Department, A. I. Yevdokimov Moscow State University of Medicine and Dentistry.
Moscow
Phone: +7 (499) 785-90-91
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For citations:
Smirnova T.G., Chernousova L.N., Varlamov D.A., Sochivko D.G., Ergeshov A.E. Intraspecific Diversity of Mycobacterium abscessus Isolated from Patients with Pulmonary Lesions. Tuberculosis and Lung Diseases. 2023;101(4):40-45. (In Russ.) https://doi.org/10.58838/2075-1230-2023-101-4-40-45
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