Sarcoidosis Phenotyping: Analysis of Current Approaches (Review)
https://doi.org/10.58838/2075-1230-2024-102-3-84-94
Abstract
The review analyzes publications devoted to the formation of phenotypes in sarcoidosis patients. It has been noted that there is a certain difficulty in phenotyping the disease that can affect all human organs and systems. The article demonstrates the trend to shift from Scadding radiographic stages of intrathoracic sarcoidosis, based on radiography, to phenotypes based on high-resolution computed tomography. It presents phenotypes based on such parameters as organ damage, respiratory dysfunction, laboratory and genetic data, and treatment effects. The authors note that phenotypes should be applicable to clinical practice and clearly reflect differences between patients and the likelihood of clinically significant outcomes.
Supporting agencies: The study was initiated by the investigator and no targeted funding was allocated for it.
About the Authors
A. A. Vizel
Kazan State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Aleksandr A. Vizel, Doctor of Medical Sciences, Professor, Honored Doctor of the Republic of Tatarstan, Head of Phthisiopulmonology Department
49, Butlerova St., Kazan, 420012
Phone: +7 (843) 236-09-22
S. N. Avdeev
I.M. Sechenov First Moscow State Medical University (Sechenov University), Russian Ministry of Health; Pulmonology Research Institute by the Russian Federal Medical Biological Agency
Russian Federation
Russian Federation
Sergey N. Avdeev, Doctor of Medical Sciences, Professor, Academician of RAS, Head of Pulmonology Department, Institute of Clinical Medicine named after N.V. Sklifosovsky; Chief Pulmonologist of the Russian Ministry of Health, Head of Clinical Department
8, Bd. 2, Trubetskaya St., Moscow 119991
Phone: +7 (495) 708-35-76
I. Yu. Vizel
Kazan State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Irina Yu. Vizel, Doctor of Medical Sciences, Associate Professor of Phthisiopulmonology Department, Professor of the Russian Academy of Natural Sciences
49, Butlerova St., Kazan, 420012
Phone: +7 (843) 236-09-22
G. R. Shakirova
Kazan State Medical University, Russian Ministry of Health; Republican Clinical Hospital, Ministry of Health of the Republic of Tatarstan
Russian Federation
Russian Federation
Gulnaz R. Shakirova, Candidate of Medical Sciences, Assistant of Phthisiopulmonology Department, Pulmonologist of Republican Clinical Hospital
49, Butlerova St., Kazan, 420012
Phone: +7 (843) 236-09-22
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Review
For citations:
Vizel A.A., Avdeev S.N., Vizel I.Yu., Shakirova G.R. Sarcoidosis Phenotyping: Analysis of Current Approaches (Review). Tuberculosis and Lung Diseases. 2024;102(3):84-94. (In Russ.) https://doi.org/10.58838/2075-1230-2024-102-3-84-94
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